Nagelhout Pharmacology 1 Exam 2 Questions
with Correctly Verified Answers
What is the MAC of Isoflurane? - ANSWER-1.15
What is the MAC of Sevoflurane? - ANSWER-2
What is the MAC of Desflurane? - ANSWER-5.8
What is the MAC of N2O? - ANSWER-105
What is MAC? - ANSWER-the minimum alveolar concentration needed to achieve
surgical anesthesia (immobility) in 50% of patients exposed to noxious stimuli. Think:
anesthesia gas dose
Blood/Gas Partition Coefficient of Isoflurane - ANSWER-1.4
Blood/Gas Partition Coefficient of Sevoflurane - ANSWER-0.6
Blood/Gas Partition Coefficient of Desflurane - ANSWER-0.42
Blood/Gas Partition Coefficient of N2O - ANSWER-0.47
Blood/Gas Partition Coefficient is a measure of _________. - ANSWER-speed...how
fast you go to sleep and how fast you wake up
Put gasses in order of fastest to slowest - ANSWER-N2O
Desflurane
Sevoflurane
Isoflurane
Oil/Gas Coefficient of Isoflurane - ANSWER-99
Oil-Gas Coefficient of Sevoflurane - ANSWER-50
Oil/Gas Coefficient of N2O - ANSWER-1.4
Oil/Gas Coefficient of Desflurane - ANSWER-18.7
Oil/Gas Partition Coefficient is a measure of........ - ANSWER-potentcy
Put gasses in order of most potent to least potent - ANSWER-Isoflurane
Sevoflurane
Desflurane
N2O
, An INCREASE in cardiac output ________ the onset of all anesthetic gasses. -
ANSWER-slows
A DECREASE in cardiac output ________ the onset of al anesthetic gasses. -
ANSWER-speeds
Which gases will be effected the most by an increase in cardiac output? - ANSWER-the
highest blood/gas coefficient gases (slowest)
A ventilation/perfusion deficit ________ the delivery of all anesthetic gases. - ANSWER-
slows
Which gases will be effect most by a ventilation/perfusion deficit? - ANSWER-the faster
inhalation agents (lowest blood/gas partition coefficient) are effected more than the
slower inhalation agents (higher blood/gas partition coefficient)
What are the volatile gas anesthetics? - ANSWER-Iso, Sevo, Des....these start in liquid
phase and have to be "volatilized" (vaporized) in order to be administered.
What are the non-volatile gas anesthetics? - ANSWER-Nitrous Oxide....already in gas
form from the wall
___________ is the only inorganic gas.
All other gases are __________. - ANSWER-Nitrous Oxide. Contains no carbons
Halogenated Ethers
What anesthetics have a GABAMIMETIC mechanism of action? - ANSWER-gases
propofol
benzos
etomidate
Which anesthetics have a NMDA ANTAGONIST mechanism of action? - ANSWER-
ketamine
Which anesthetics have a PSA2 ANTAGONIST mechanism of action? - ANSWER-
dexmetatomadine
What does a GABA RECEPTOR do? - ANSWER-increases chloride production
What does an NMDA RECEPTOR do? - ANSWER-ketamine blocks GLUTIMATE from
attaching to it
Effects of gas anesthetics on the CNS and ANS - ANSWER-dose dependent
depression
decreased oxygen consumption- CMRO2
decreased intraoccular pressure
with Correctly Verified Answers
What is the MAC of Isoflurane? - ANSWER-1.15
What is the MAC of Sevoflurane? - ANSWER-2
What is the MAC of Desflurane? - ANSWER-5.8
What is the MAC of N2O? - ANSWER-105
What is MAC? - ANSWER-the minimum alveolar concentration needed to achieve
surgical anesthesia (immobility) in 50% of patients exposed to noxious stimuli. Think:
anesthesia gas dose
Blood/Gas Partition Coefficient of Isoflurane - ANSWER-1.4
Blood/Gas Partition Coefficient of Sevoflurane - ANSWER-0.6
Blood/Gas Partition Coefficient of Desflurane - ANSWER-0.42
Blood/Gas Partition Coefficient of N2O - ANSWER-0.47
Blood/Gas Partition Coefficient is a measure of _________. - ANSWER-speed...how
fast you go to sleep and how fast you wake up
Put gasses in order of fastest to slowest - ANSWER-N2O
Desflurane
Sevoflurane
Isoflurane
Oil/Gas Coefficient of Isoflurane - ANSWER-99
Oil-Gas Coefficient of Sevoflurane - ANSWER-50
Oil/Gas Coefficient of N2O - ANSWER-1.4
Oil/Gas Coefficient of Desflurane - ANSWER-18.7
Oil/Gas Partition Coefficient is a measure of........ - ANSWER-potentcy
Put gasses in order of most potent to least potent - ANSWER-Isoflurane
Sevoflurane
Desflurane
N2O
, An INCREASE in cardiac output ________ the onset of all anesthetic gasses. -
ANSWER-slows
A DECREASE in cardiac output ________ the onset of al anesthetic gasses. -
ANSWER-speeds
Which gases will be effected the most by an increase in cardiac output? - ANSWER-the
highest blood/gas coefficient gases (slowest)
A ventilation/perfusion deficit ________ the delivery of all anesthetic gases. - ANSWER-
slows
Which gases will be effect most by a ventilation/perfusion deficit? - ANSWER-the faster
inhalation agents (lowest blood/gas partition coefficient) are effected more than the
slower inhalation agents (higher blood/gas partition coefficient)
What are the volatile gas anesthetics? - ANSWER-Iso, Sevo, Des....these start in liquid
phase and have to be "volatilized" (vaporized) in order to be administered.
What are the non-volatile gas anesthetics? - ANSWER-Nitrous Oxide....already in gas
form from the wall
___________ is the only inorganic gas.
All other gases are __________. - ANSWER-Nitrous Oxide. Contains no carbons
Halogenated Ethers
What anesthetics have a GABAMIMETIC mechanism of action? - ANSWER-gases
propofol
benzos
etomidate
Which anesthetics have a NMDA ANTAGONIST mechanism of action? - ANSWER-
ketamine
Which anesthetics have a PSA2 ANTAGONIST mechanism of action? - ANSWER-
dexmetatomadine
What does a GABA RECEPTOR do? - ANSWER-increases chloride production
What does an NMDA RECEPTOR do? - ANSWER-ketamine blocks GLUTIMATE from
attaching to it
Effects of gas anesthetics on the CNS and ANS - ANSWER-dose dependent
depression
decreased oxygen consumption- CMRO2
decreased intraoccular pressure
