PSB Exam 1 Study Guide Questions and
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Depolarization of the axon terminal causes influx of what ion?
Ans: Calcium
What is triggered by influx of the ion listed above?
Ans: exocytosis
What are the two basic mechanisms for inactivation neurotransmitter
in the synaptic cleft?
Ans: After a chemical is released, it must be inactivated. Inactivation can
be through a reuptake mechanism or by an enzyme that stops the action
of the chemical.
Neurotransmitters:
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Ans: communicate locally across
the synapse
Neuromodulators:
Ans: communicate with target cells more distant than the synapse by
diffusing away from the point of release
A _____________ synapse is comprised of an axon of a "transmitting"
neuron synapsing on the dendrite of a "receiving" neuron
Ans: axo dendritic
List one catecholaminergic drug and its effects on synaptic
transmission, being sure to indicate which catecholamine the drug
affects
Ans: Cocaine, no re-uptake of dopamine so there is a ton of dopamine in
synaptic cleft making guy have a lot of euphoria
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The anti-psychotic drug haloperidol is particularly selective for
dopamine _______ receptors..
A) D1
B) D2
C) D3
D) auto-
Ans: B) D2
Most antipsychotic medications act by blocking _______ receptors.
A) serotonergic
B) dopaminergic
C) cholinergic
D) muscarinic
Ans: B) dopaminergic
List one cholinergic drug and its effect on synaptic transmission