PHARMA MID SEM TEST QUESTIONS AND CORRECT ANSWERS
100% VERIFIED!!
Which of the following is an important effect of insulin? - ANSWER Increased glucose
transport into adipose and muscle cells
Genetic variations in which of the following would be LIKELY to affect the
pharmacodynamics of a drug? - ANSWER Drug receptors
A 69 year-old woman with hypertension presents to her cardiologist with a complaint of
increased irritability, muscle twitches and cramps of recent onset. The specialist does
an ECG and notices some characteristic changes. He suspects this is due to the
antihypertensive drug she is on.
What is the MOST LIKELY cause of these recent signs and symptoms and which drug is
LIKELY to have caused them? - ANSWER hyperkalaemia, as a result of taking captopril
A 25 year-old woman sees her doctor because she is suffering with insomnia and fears
she may have "something wrong with her heart". She describes "her heart jumping out
of her chest". She feels healthy otherwise and reports she has lots of energy. Lab tests
confirm hyperthyroidism. - ANSWER Radioactive Iodine 131
A 78 year-old man has a 10 year history of hypertension. His BP today is 158/82 mm Hg
(156/84 mm Hg when repeated) and his heart rate is 60 beats/min. He is currently on
lisinopril and amlodipine daily, and is not overweight.
Which of the following is the MOST appropriate medication to add to improve blood
pressure control? - ANSWER Hydrochlorothiazide
A drug that is a weak acid is largely excreted unchanged by the kidneys, and a patient
has taken too high a dose.
, How could the rate of its excretion be INCREASED to try and reduce the risk of toxic
effects? - ANSWER The pH of the urine should be increased
A 72 year-old man is diagnosed with Hashimoto's thyroiditis and is prescribed thyroxine.
Thyroxine is used because it: - ANSWER has a longer half life and will release the more
active T3 at the site of action
A drug with a generic name ending in -pril would be used to: - ANSWER control blood
pressure
A 58 year-old postmenopausal woman was sent for dual-energy x-ray absorptiometry to
evaluate her bone mineral density. The test results revealed significantly low bone
mineral density in all sites tested.
Chronic use of which of the following medications is MOST LIKELY to have contributed
to this woman's osteoporosis? - ANSWER Prednisone
A 65 year-old woman comes to the emergency department with atypical chest pain. Her
ECG reveals ventricular tachycardia and ST-segment elevation. Troponin C levels are
markedly increased, suggesting myocardial damage. A diagnosis of myocardial
infarction is made, and the woman is admitted to the cardiac intensive care unit.
What would be the MOST appropriate drug to treat her arrhythmia immediately? -
ANSWER Flecainide
A new formulation of an antimicrobial drug is being tested for its equivalence to the
standard formulation. A trial is carried out using volunteers being treated for bladder
infections. The volunteers are randomised into two groups, and one group receives the
standard antimicrobial formulation, while the second receives the new formulation, The
active drug is the same in each formulation. Each person takes a single dose of 50 mg of
the drug and the plasma concentration is measured at a fixed time from administration,
after absorption has occured. In addition, all patients are monitored for clinical
improvement of their infections. After 7 days, the average plasma concentration of the
standard formulation is found to be 2 mg/mL, while the average plasma concentration of
the test formulation is 15 mg/mL. In terms of clinical response, the group given the
standard formulation all showed clinical improvement or resolutio - ANSWER The
volume of distribution of the standard formulation is 25 L, while that of the test
formulation is 3.3 L, suggesting that the test formulation is highly plasma protein bound,
and is largely remaining in the circulation
100% VERIFIED!!
Which of the following is an important effect of insulin? - ANSWER Increased glucose
transport into adipose and muscle cells
Genetic variations in which of the following would be LIKELY to affect the
pharmacodynamics of a drug? - ANSWER Drug receptors
A 69 year-old woman with hypertension presents to her cardiologist with a complaint of
increased irritability, muscle twitches and cramps of recent onset. The specialist does
an ECG and notices some characteristic changes. He suspects this is due to the
antihypertensive drug she is on.
What is the MOST LIKELY cause of these recent signs and symptoms and which drug is
LIKELY to have caused them? - ANSWER hyperkalaemia, as a result of taking captopril
A 25 year-old woman sees her doctor because she is suffering with insomnia and fears
she may have "something wrong with her heart". She describes "her heart jumping out
of her chest". She feels healthy otherwise and reports she has lots of energy. Lab tests
confirm hyperthyroidism. - ANSWER Radioactive Iodine 131
A 78 year-old man has a 10 year history of hypertension. His BP today is 158/82 mm Hg
(156/84 mm Hg when repeated) and his heart rate is 60 beats/min. He is currently on
lisinopril and amlodipine daily, and is not overweight.
Which of the following is the MOST appropriate medication to add to improve blood
pressure control? - ANSWER Hydrochlorothiazide
A drug that is a weak acid is largely excreted unchanged by the kidneys, and a patient
has taken too high a dose.
, How could the rate of its excretion be INCREASED to try and reduce the risk of toxic
effects? - ANSWER The pH of the urine should be increased
A 72 year-old man is diagnosed with Hashimoto's thyroiditis and is prescribed thyroxine.
Thyroxine is used because it: - ANSWER has a longer half life and will release the more
active T3 at the site of action
A drug with a generic name ending in -pril would be used to: - ANSWER control blood
pressure
A 58 year-old postmenopausal woman was sent for dual-energy x-ray absorptiometry to
evaluate her bone mineral density. The test results revealed significantly low bone
mineral density in all sites tested.
Chronic use of which of the following medications is MOST LIKELY to have contributed
to this woman's osteoporosis? - ANSWER Prednisone
A 65 year-old woman comes to the emergency department with atypical chest pain. Her
ECG reveals ventricular tachycardia and ST-segment elevation. Troponin C levels are
markedly increased, suggesting myocardial damage. A diagnosis of myocardial
infarction is made, and the woman is admitted to the cardiac intensive care unit.
What would be the MOST appropriate drug to treat her arrhythmia immediately? -
ANSWER Flecainide
A new formulation of an antimicrobial drug is being tested for its equivalence to the
standard formulation. A trial is carried out using volunteers being treated for bladder
infections. The volunteers are randomised into two groups, and one group receives the
standard antimicrobial formulation, while the second receives the new formulation, The
active drug is the same in each formulation. Each person takes a single dose of 50 mg of
the drug and the plasma concentration is measured at a fixed time from administration,
after absorption has occured. In addition, all patients are monitored for clinical
improvement of their infections. After 7 days, the average plasma concentration of the
standard formulation is found to be 2 mg/mL, while the average plasma concentration of
the test formulation is 15 mg/mL. In terms of clinical response, the group given the
standard formulation all showed clinical improvement or resolutio - ANSWER The
volume of distribution of the standard formulation is 25 L, while that of the test
formulation is 3.3 L, suggesting that the test formulation is highly plasma protein bound,
and is largely remaining in the circulation
