r
ANEMIA
, ·
Features of RBCs :
(i) Size :
7-8Mm >
-
compared the nucleus of
lymphocytes
(ii) Life Span
: 120
days
(iii) Enucleate
(iv) central 1/3rd pallor
iv)
Shape
: Biconcave disc-spectin maintains the
shape
·
Development of RBCs :
Hematopoietic Stem cells
↓
Common Myeloid Progenitor
·
↓
PROERYTHRO BLAST
intense
blue T ↓
colorful
(Basophilic) EARLY NORMOBLAST
T ↓
(Polychromatic) INTERMEDIATE NORMOBLAST
↓
(Orthochromic) LATE NORMOBLAST
↓ D
-
RETICULOCYTE
↓ ⑧Nucleus
RBC · ~
starts
* Hb
synthesis in
pooerythoblast
* HD first appears on
microscopy in Int normoblast
·
Reticulocyte :
>
-
Immediate precursor of RBCs
>
- It has no nucleus
>
-
Normal count =
0 5-1 5
.
%.
visualization of reticulocyte
special stain for :
>
-
(i) New-methylene blue
(ii Brilliant
3 supra vital
cresyl blue stair
, Reticulocytosis (4) Rulocytopenia (N)
~
Acute & chronic blood loss -
Aplastic Anemia
Hemolytic Anemia Megaloblastic Anemia
~ ~
~
Response to He in FelBiL ~
Bone Marrow
suppression
anemia
deficiency
corrected Metic Count = Retic %
HCHC
x
age
ACT = Ab % x 3
ReticulocyteProduction Index
-ion time
In the
e
45
Maturation
35
1 .
5 days
25
2 days
15 2 .
5 days
>
-
Polychromatic RBCs in a PBS represents reticulocyte
, ·
RBC Indices :
(i) Mean Corpuscular Volume (MCV)
>
-
Indication of arg .
volume/size of RBC
>
- Normal
Range = 82-96 fl
>
-
Types of Anemia according to MCV :
w ~ ~
Microcytic Normocytic Macrocytic
(MCV < 80ft) (MCV-80-100 f) (MCV > 100f)
Anemia
Sideroblastic A Aplastic Liver disease
Hemolytic Anemia
A
Iron
deficiency A of chronic disease Hypothyroidism
Thalassemia
A of chronic disease
Renal disease Megaloblastic
Cytotoxic drugs
MCV-count
(ii) Mean Corpuscular Hemoglobin (MCH)
Aug volume of hemoglobin in single RBC
>
-
a
Hb
MCH =
RBC count
>
-
Normal Range
=
27-32
pg
>
-
According to MCH Anemia can be :
↓ +
Normochromic
chromic
MCH = 27 -
32p9 MCH < 27
Pg
ANEMIA
, ·
Features of RBCs :
(i) Size :
7-8Mm >
-
compared the nucleus of
lymphocytes
(ii) Life Span
: 120
days
(iii) Enucleate
(iv) central 1/3rd pallor
iv)
Shape
: Biconcave disc-spectin maintains the
shape
·
Development of RBCs :
Hematopoietic Stem cells
↓
Common Myeloid Progenitor
·
↓
PROERYTHRO BLAST
intense
blue T ↓
colorful
(Basophilic) EARLY NORMOBLAST
T ↓
(Polychromatic) INTERMEDIATE NORMOBLAST
↓
(Orthochromic) LATE NORMOBLAST
↓ D
-
RETICULOCYTE
↓ ⑧Nucleus
RBC · ~
starts
* Hb
synthesis in
pooerythoblast
* HD first appears on
microscopy in Int normoblast
·
Reticulocyte :
>
-
Immediate precursor of RBCs
>
- It has no nucleus
>
-
Normal count =
0 5-1 5
.
%.
visualization of reticulocyte
special stain for :
>
-
(i) New-methylene blue
(ii Brilliant
3 supra vital
cresyl blue stair
, Reticulocytosis (4) Rulocytopenia (N)
~
Acute & chronic blood loss -
Aplastic Anemia
Hemolytic Anemia Megaloblastic Anemia
~ ~
~
Response to He in FelBiL ~
Bone Marrow
suppression
anemia
deficiency
corrected Metic Count = Retic %
HCHC
x
age
ACT = Ab % x 3
ReticulocyteProduction Index
-ion time
In the
e
45
Maturation
35
1 .
5 days
25
2 days
15 2 .
5 days
>
-
Polychromatic RBCs in a PBS represents reticulocyte
, ·
RBC Indices :
(i) Mean Corpuscular Volume (MCV)
>
-
Indication of arg .
volume/size of RBC
>
- Normal
Range = 82-96 fl
>
-
Types of Anemia according to MCV :
w ~ ~
Microcytic Normocytic Macrocytic
(MCV < 80ft) (MCV-80-100 f) (MCV > 100f)
Anemia
Sideroblastic A Aplastic Liver disease
Hemolytic Anemia
A
Iron
deficiency A of chronic disease Hypothyroidism
Thalassemia
A of chronic disease
Renal disease Megaloblastic
Cytotoxic drugs
MCV-count
(ii) Mean Corpuscular Hemoglobin (MCH)
Aug volume of hemoglobin in single RBC
>
-
a
Hb
MCH =
RBC count
>
-
Normal Range
=
27-32
pg
>
-
According to MCH Anemia can be :
↓ +
Normochromic
chromic
MCH = 27 -
32p9 MCH < 27
Pg
