PATH 1016, INFLAMMATION AND TISSUE REPAIR EXAM WITH
COMPLETE SOLUTIONS 100% VERIFIED!!
inflammation definition
An innate, automatic response to cell/tissue injury that:
- Neutralizes harmful agents
- Removes damaged and dead tissue
- Generates new tissue
- Promotes healing
inflammation vs infection
the body's response to injury= inflammation
invasion of bacteria/virus= infection
local inflammatory response
always occur in relation to trauma
- ex: single inflamed joint
systematic inflammatory response
always occur in relation to severe injury or multiple trauma
- caused by hormonal, metabolic and immunological mediators
,role of inflammatory processes
localize, destroy, neutralize, and remove injurious agents in preparation for the
process of healing
cells of inflammation
Endothelial cells
Platelets
Leukocytes or WBC's
cells of inflammation: neutrophils
scavenger cells, engulfs bacteria (pathogens) &cellular debris through phagocytosis
cells of inflammation: monocytes (macrophages)
- assist in phagocytosis and active in bacterial killing
- produce potent inflammatory mediators
- important in chronic inflammation
- contribute to healing process
cells of inflammation: lymphocytes
participate in immune-mediated inflammationcaused by infectious agents as well as
chronicinflammation and non-immune-mediatedinflammation
, inflammatory mediators
chemical mediators responsible for inflammatory events
two types:
- plasma derived (liver)
- cell derived
inflammatory mediators: plasma derived
synthesized in the liver
kinin system
products of coagulation and fibrinolysis proteins
proteins of complement system
inflammatory mediators: plasma derived - kinins
increased capillary permeability
ex: bradykinin
inflammatory mediators: plasma derived - products of coagulation and fibrinolysis
proteins
ex: fibrin-platelet clots
inflammatory mediators: plasma derived - proteins of complement system
consists of cascade of plasma proteins that play an important role in immunity &
inflammationVasodilation & vascular permeability
COMPLETE SOLUTIONS 100% VERIFIED!!
inflammation definition
An innate, automatic response to cell/tissue injury that:
- Neutralizes harmful agents
- Removes damaged and dead tissue
- Generates new tissue
- Promotes healing
inflammation vs infection
the body's response to injury= inflammation
invasion of bacteria/virus= infection
local inflammatory response
always occur in relation to trauma
- ex: single inflamed joint
systematic inflammatory response
always occur in relation to severe injury or multiple trauma
- caused by hormonal, metabolic and immunological mediators
,role of inflammatory processes
localize, destroy, neutralize, and remove injurious agents in preparation for the
process of healing
cells of inflammation
Endothelial cells
Platelets
Leukocytes or WBC's
cells of inflammation: neutrophils
scavenger cells, engulfs bacteria (pathogens) &cellular debris through phagocytosis
cells of inflammation: monocytes (macrophages)
- assist in phagocytosis and active in bacterial killing
- produce potent inflammatory mediators
- important in chronic inflammation
- contribute to healing process
cells of inflammation: lymphocytes
participate in immune-mediated inflammationcaused by infectious agents as well as
chronicinflammation and non-immune-mediatedinflammation
, inflammatory mediators
chemical mediators responsible for inflammatory events
two types:
- plasma derived (liver)
- cell derived
inflammatory mediators: plasma derived
synthesized in the liver
kinin system
products of coagulation and fibrinolysis proteins
proteins of complement system
inflammatory mediators: plasma derived - kinins
increased capillary permeability
ex: bradykinin
inflammatory mediators: plasma derived - products of coagulation and fibrinolysis
proteins
ex: fibrin-platelet clots
inflammatory mediators: plasma derived - proteins of complement system
consists of cascade of plasma proteins that play an important role in immunity &
inflammationVasodilation & vascular permeability
