NGR 5172 - Advanced Pharmacology - Final Exam
Questions With Complete Solutions
A 13-year-old boy presents with acute bacterial rhino sinusitis.
He has a beta-lactam allergy and had taken clarithromycin 2
months ago for a "bad cold." You recommend treatment with:
Levofloxacin.
All of the following antimicrobials would be expected to exhibit
in vitro activity against beta-lactamase-producing Moraxella
catarrhalis except:
Amoxicillin.
A 26-year-old woman presents with uncomplicated UTI. She is
otherwise healthy, has not received any systemic antimicrobials
in the past year, does not have a sulfa allergy, and is not taking
any medications other than Ortho-Cyclen (ethinyl estradiol and
norgestimate) for birth control. Her last menstrual period began
10 days ago. The local E. coli resistance rate to TMP/SMX is
about 10%. The preferred therapy for this patient is:
Trimethoprim-sulfamethoxazole.
A 46-year-old man who is currently smoking 1 PPD and has a
30 pack-year cigarette smoking history with penicillin allergy
presents with acute bacterial rhino sinusitis. Three weeks ago, he
was treated with a macrolide for "bronchitis." You know
prescribe:
,Levofloxacin.
A 35-year-old woman who is not pregnant was initiated on high-
dose amoxicillin 4 days ago to treat acute bacterial rhino
sinusitis. She returns complaining of no change in symptoms.
You recommend switching her treatment to:
Levofloxacin.
A 35-year-old woman with a sulfa allergy presents with an
uncomplicated UTI. She has not received any systemic
antimicrobials in more than 6 months. She is currently not
pregnant and is using norelgestromin/ethinyl estradiol patch
(Orto Evra). You recommend treatment with:
Nitrofurantoin
An antibiotic described as having bacteriostatic action is capable
of:
Inhibiting growth or reproduction of an organism.
According to the CDC guidelines for prescribing opioids, which
of the following is false when considering treatment of chronic
pain?
If opioids are used, they should not be combined with non-
opioid therapy and non-pharmacologic therapy.
All of the following are opiate agonist/antagonist combinations
except:
Hydrocodone/ibuprofen (Vicoprofen).
,Amphotericin B is an antifungal agent used in the management
of serious fungal infection. This drug is characterized by a
variety of significant adverse effects. Which of the following is
the electrolyte abnormality most often associated with
amphotericin B?
Hypokalemia
Which of the following agents is beta 1 selective?
Atenolol
Which of the following statements about beta-adrenergic
blockers is correct?
Some beta-adrenergic blockers are cardioselective, blocking
only beta 1 receptors; others are not and also block beta 2
receptors in smooth muscle.
The beta-adrenergic agonist nebivolol:
Is highly cardioselective.
During diuretic therapy, levels of which electrolyte should be
monitored?
Potassium
Thiazide diuretics and loop diuretics have different primary
indications because of which important difference between
them?
, Thiazide diuretics require luminal perfusion to reach their
active site.
During diuretic therapy, which of the following should be
monitored?
Renal function
Which of the following is a mechanism of action of beta-
adrenergic blockers?
Preventing sympathetic stimulation of the heart
Which type of diuretic is available only for oral use?
Potassium-sparing diuretics
Which of the following best characterizes the mechanism of
action of diuretics?
Diuretics inhibit the transport of ions across the tubular
membrane.
Which of the following statements about angiotensin II receptor
blockers is correct?
Renal alterations are less common than with ACE inhibitors.
The baseline laboratory evaluation of patients taking ACE
inhibitors should include:
Urine protein.
Questions With Complete Solutions
A 13-year-old boy presents with acute bacterial rhino sinusitis.
He has a beta-lactam allergy and had taken clarithromycin 2
months ago for a "bad cold." You recommend treatment with:
Levofloxacin.
All of the following antimicrobials would be expected to exhibit
in vitro activity against beta-lactamase-producing Moraxella
catarrhalis except:
Amoxicillin.
A 26-year-old woman presents with uncomplicated UTI. She is
otherwise healthy, has not received any systemic antimicrobials
in the past year, does not have a sulfa allergy, and is not taking
any medications other than Ortho-Cyclen (ethinyl estradiol and
norgestimate) for birth control. Her last menstrual period began
10 days ago. The local E. coli resistance rate to TMP/SMX is
about 10%. The preferred therapy for this patient is:
Trimethoprim-sulfamethoxazole.
A 46-year-old man who is currently smoking 1 PPD and has a
30 pack-year cigarette smoking history with penicillin allergy
presents with acute bacterial rhino sinusitis. Three weeks ago, he
was treated with a macrolide for "bronchitis." You know
prescribe:
,Levofloxacin.
A 35-year-old woman who is not pregnant was initiated on high-
dose amoxicillin 4 days ago to treat acute bacterial rhino
sinusitis. She returns complaining of no change in symptoms.
You recommend switching her treatment to:
Levofloxacin.
A 35-year-old woman with a sulfa allergy presents with an
uncomplicated UTI. She has not received any systemic
antimicrobials in more than 6 months. She is currently not
pregnant and is using norelgestromin/ethinyl estradiol patch
(Orto Evra). You recommend treatment with:
Nitrofurantoin
An antibiotic described as having bacteriostatic action is capable
of:
Inhibiting growth or reproduction of an organism.
According to the CDC guidelines for prescribing opioids, which
of the following is false when considering treatment of chronic
pain?
If opioids are used, they should not be combined with non-
opioid therapy and non-pharmacologic therapy.
All of the following are opiate agonist/antagonist combinations
except:
Hydrocodone/ibuprofen (Vicoprofen).
,Amphotericin B is an antifungal agent used in the management
of serious fungal infection. This drug is characterized by a
variety of significant adverse effects. Which of the following is
the electrolyte abnormality most often associated with
amphotericin B?
Hypokalemia
Which of the following agents is beta 1 selective?
Atenolol
Which of the following statements about beta-adrenergic
blockers is correct?
Some beta-adrenergic blockers are cardioselective, blocking
only beta 1 receptors; others are not and also block beta 2
receptors in smooth muscle.
The beta-adrenergic agonist nebivolol:
Is highly cardioselective.
During diuretic therapy, levels of which electrolyte should be
monitored?
Potassium
Thiazide diuretics and loop diuretics have different primary
indications because of which important difference between
them?
, Thiazide diuretics require luminal perfusion to reach their
active site.
During diuretic therapy, which of the following should be
monitored?
Renal function
Which of the following is a mechanism of action of beta-
adrenergic blockers?
Preventing sympathetic stimulation of the heart
Which type of diuretic is available only for oral use?
Potassium-sparing diuretics
Which of the following best characterizes the mechanism of
action of diuretics?
Diuretics inhibit the transport of ions across the tubular
membrane.
Which of the following statements about angiotensin II receptor
blockers is correct?
Renal alterations are less common than with ACE inhibitors.
The baseline laboratory evaluation of patients taking ACE
inhibitors should include:
Urine protein.
