Solutions
First person to coin "alkaloid" date ANS Meissner 1818
Over ____ alkaloids discovered from how many families ANS Over 10k alkaloids discovered
from 00 plant families
Most important alkaloids are ANS BASIC
Who discovered morphine ANS German pharmacists, Friedrich Wilhelm Adam Sertürner,
discovered
opium's main narcotic principle, morphine
T/F free alkaloids are more stable than salts and are more common ANS False- salts are more
common and more stable -- salts are usually soluble in water
Most alkaloids (basic ones) when administered orally will form ___ and _____ ANS will form
salts and not be readily absorbed in stomach
Name a non-basic alkaloid that is absorbed in the stomach ANS Caffeine
IV alkaloids are usually administered as ANS salts
Caffeine 2 main effects ANS CNS stimulant, diuretic
Theobromine 2 main effects and lack of effect ANS diuretic, SM muscle relaxant, little CNS
activity
Percentages of caffeine products (natural) ANS Coffee seeds 1-2%
, Decaffeinated coffee seed up to 0.08%
Cocoa 0.07- 0.2 %
Black Tea leaves 1-4%
Percentages of theobromine products ANS Theobromine
• Cocoa beans 1-4% Theobromine
Mgs of caffeine in drinks ANS Cup (6 oz.) espresso coffee: 310 mg
Cup (6 oz.) boiled coffee: 100 mg
Cup (6 oz.) instant coffee: 65 mg
Cup (6 oz.) tea: 10-50 mg
Can (6 oz.) Coca cola: 20 mg
Can (6 oz.) Pepsi cola: 10 mg
LD50 for caffeine ANS 150 to 200 milligrams
per kilogram
(reports of death after 2g)
nicotine comes from what plant ANS Nicotiana tabacum
(Solanacea family)
Nicotine in other solanacea outside of tobacco ANS Nicotine is present in tomatoes, potatoes,
and peppers in
the range of 2−7 µg/kg for fresh fruits. The nicotine
concentrations in tomatoes decreased significantly with
increasing degree of ripening of the fruits.
nicotine in a cigarette ANS A cigarette contains between 0.7 and 2 mg (20 - 45%