(NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE
Updated May 2023 – Verified Q&A + Rationales
Content Coverage: 1700+ Key Concepts
Focus: High-Yield NCLEX Review
Prepared For: Nursing Students & NCLEX Candidates
Purpose: Rapid Review, Exam Preparation & Clinical Recall
Ä HIGH-YIELD NCLEX REVIEW NOTES
Rapid Questions & Answers
NEUROLOGY
Occipital lobe damage causes:
→ Visual disturbances
Worst headache of life indicates:
→ Possible aneurysm
Homonymous hemianopsia:
→ Loss of same half of visual field
Signs of increased ICP:
→ Altered LOC, headache, vomiting, ↑BP, ↓pulse
Cushing’s triad:
→ Bradycardia, slow respirations, widened pulse pressure
Decerebrate posturing indicates:
→ Severe brain injury
î EMERGENCIES
First-line drug for anaphylaxis:
→ IM epinephrine
Fat embolism risk:
→ Long bone or pelvic fractures
Retroperitoneal hemorrhage signs:
→ Hypotension, back pain, flank bruising (Grey-Turner sign)
Page 1 of 124 3/23/2026, 4:16:49 PM
, (NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
Seizure nursing care:
● Turn patient to side
● Protect airway
● Do NOT restrain
● Do NOT insert objects in mouth
❤ CARDIOVASCULAR
Normal sodium:
→ 135–145 mEq/L
Normal WBC:
→ 4,000–11,000
Normal platelets:
→ 150,000–400,000
Heparin monitoring:
→ PTT (1.5–2× normal)
Warfarin monitoring:
→ INR
Clopidogrel:
→ Antiplatelet
| RESPIRATORY
Asthma treatment:
→ Albuterol
Side effects: tremor, palpitations, insomnia
Crackles (rales) indicate:
→ Fluid in lungs
Atelectasis sounds:
→ Fine crackles
Active TB symptoms:
→ Cough, fever, night sweats, weight loss
TB precautions:
→ Airborne + negative pressure + N95
Page 2 of 124 3/23/2026, 4:16:49 PM
, (NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
LAB VALUES
Creatinine:
→ 0.6–1.3
BUN:
→ 6–20
Vancomycin trough:
→ 10–20
Elevated BUN & creatinine:
→ Kidney injury
x PHARMACOLOGY
Phenytoin side effect:
→ Gingival hyperplasia
Calcium channel blockers end in:
→ “-pine”
Adverse effects:
→ Dizziness, edema, constipation
Spironolactone:
→ Potassium-sparing diuretic
Furosemide monitoring:
→ BP, potassium, kidney function
PPIs risk:
→ C. difficile infection
d PEDIATRICS
Mongolian spots:
→ Benign bluish-gray discoloration
Wilms tumor:
→ Kidney tumor (DO NOT palpate abdomen)
1-year-old pulse:
→ 100–160 bpm
Page 3 of 124 3/23/2026, 4:16:49 PM
, (NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
Intussusception:
→ “Currant jelly stool”
→ Treated with air enema
b OBSTETRICS
HELLP syndrome:
→ Hemolysis, Elevated liver enzymes, Low platelets
Oxytocin:
→ Labor induction (monitor closely)
Preterm labor risk:
→ Infection
TORCH infections:
→ Cause fetal abnormalities
DISEASES & CONDITIONS
Fifth disease:
→ Parvovirus B19 (“slapped cheek”)
Cystic fibrosis care:
→ Chest physiotherapy
→ High-calorie diet
Chronic kidney disease diet:
→ ↓ Sodium, potassium, phosphorus, fluids
Peripheral arterial disease:
→ Cool, shiny, hairless skin
; NURSING PRIORITIES
First priority:
→ Airway, Breathing, Circulation
Second priority:
→ Pain, mental status, labs
Mass casualty goal:
→ Greatest good for greatest number
Page 4 of 124 3/23/2026, 4:16:49 PM
NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE
Updated May 2023 – Verified Q&A + Rationales
Content Coverage: 1700+ Key Concepts
Focus: High-Yield NCLEX Review
Prepared For: Nursing Students & NCLEX Candidates
Purpose: Rapid Review, Exam Preparation & Clinical Recall
Ä HIGH-YIELD NCLEX REVIEW NOTES
Rapid Questions & Answers
NEUROLOGY
Occipital lobe damage causes:
→ Visual disturbances
Worst headache of life indicates:
→ Possible aneurysm
Homonymous hemianopsia:
→ Loss of same half of visual field
Signs of increased ICP:
→ Altered LOC, headache, vomiting, ↑BP, ↓pulse
Cushing’s triad:
→ Bradycardia, slow respirations, widened pulse pressure
Decerebrate posturing indicates:
→ Severe brain injury
î EMERGENCIES
First-line drug for anaphylaxis:
→ IM epinephrine
Fat embolism risk:
→ Long bone or pelvic fractures
Retroperitoneal hemorrhage signs:
→ Hypotension, back pain, flank bruising (Grey-Turner sign)
Page 1 of 124 3/23/2026, 4:16:49 PM
, (NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
Seizure nursing care:
● Turn patient to side
● Protect airway
● Do NOT restrain
● Do NOT insert objects in mouth
❤ CARDIOVASCULAR
Normal sodium:
→ 135–145 mEq/L
Normal WBC:
→ 4,000–11,000
Normal platelets:
→ 150,000–400,000
Heparin monitoring:
→ PTT (1.5–2× normal)
Warfarin monitoring:
→ INR
Clopidogrel:
→ Antiplatelet
| RESPIRATORY
Asthma treatment:
→ Albuterol
Side effects: tremor, palpitations, insomnia
Crackles (rales) indicate:
→ Fluid in lungs
Atelectasis sounds:
→ Fine crackles
Active TB symptoms:
→ Cough, fever, night sweats, weight loss
TB precautions:
→ Airborne + negative pressure + N95
Page 2 of 124 3/23/2026, 4:16:49 PM
, (NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
LAB VALUES
Creatinine:
→ 0.6–1.3
BUN:
→ 6–20
Vancomycin trough:
→ 10–20
Elevated BUN & creatinine:
→ Kidney injury
x PHARMACOLOGY
Phenytoin side effect:
→ Gingival hyperplasia
Calcium channel blockers end in:
→ “-pine”
Adverse effects:
→ Dizziness, edema, constipation
Spironolactone:
→ Potassium-sparing diuretic
Furosemide monitoring:
→ BP, potassium, kidney function
PPIs risk:
→ C. difficile infection
d PEDIATRICS
Mongolian spots:
→ Benign bluish-gray discoloration
Wilms tumor:
→ Kidney tumor (DO NOT palpate abdomen)
1-year-old pulse:
→ 100–160 bpm
Page 3 of 124 3/23/2026, 4:16:49 PM
, (NCLEX-RN UWORLD COMPREHENSIVE STUDY GUIDE A+: 2026).
Intussusception:
→ “Currant jelly stool”
→ Treated with air enema
b OBSTETRICS
HELLP syndrome:
→ Hemolysis, Elevated liver enzymes, Low platelets
Oxytocin:
→ Labor induction (monitor closely)
Preterm labor risk:
→ Infection
TORCH infections:
→ Cause fetal abnormalities
DISEASES & CONDITIONS
Fifth disease:
→ Parvovirus B19 (“slapped cheek”)
Cystic fibrosis care:
→ Chest physiotherapy
→ High-calorie diet
Chronic kidney disease diet:
→ ↓ Sodium, potassium, phosphorus, fluids
Peripheral arterial disease:
→ Cool, shiny, hairless skin
; NURSING PRIORITIES
First priority:
→ Airway, Breathing, Circulation
Second priority:
→ Pain, mental status, labs
Mass casualty goal:
→ Greatest good for greatest number
Page 4 of 124 3/23/2026, 4:16:49 PM
