Pharmacology
Study GuideImmunotherapy
_ Cancer, Immune
Pharmacology
Study
Drugs
Guide
& Immunotherapy
Mechanisms
_ Cancer, Immune
of Action.pdf
Study
Drugs
Guide& Mechanisms
_ Cancer, Immune
of Action.pdf
Drugs & Mechanisms of Action.pdf
Pharmacology Immunotherapy Study
Guide | Cancer, Immune Drugs &
Mechanisms of Action
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
Pharmacology Immunotherapy
Pharmacology
Study GuideImmunotherapy
_ Cancer, Immune
Pharmacology
Study
Drugs
Guide
& Immunotherapy
Mechanisms
_ Cancer, Immune
of Action.pdf
Study
Drugs
Guide& Mechanisms
_ Cancer, Immune
of Action.pdf
Drugs & Mechanisms of Action.pdf
,Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf
glucocorticoids drugs that can inhibit the immune response by:
- decreasing inflammatory response (targets phospholipase A2)
- decreasing the abundance & activity of phagocytes
- inhibiting interleukin secretion
Clinical Uses:
- inflammatory disorders
- cancer
- ST: poison ivy
- LT: autoimmune disease
- prevention of organ transplant rejection
Extensive SE profile!
Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf
,Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf
glucocorticoids The immunosuppressive drug with the following MOAs:
1. cause lymphocytes in the blood to be re-distributed into the bone
marrow (causes leukopenia, which decreases the ability to initiate an
immune response)
2. decrease the amount of lymphoid tissue & cells in the lymph nodes &
spleen
3. decrease capillary dilation & vascular permeability
4. decrease activity of macrophages, T-cells, B-cells
5. inhibit synthesis of cell-derived inflammatory mediators
(prostaglandins, leukotrienes, thromboxanes)
- fractures Even short courses </= 1 week of steroids will increase the risk of what
- venous thromboembolism ADRs for the following 3 months?
- sepsis
Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf
, Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf
- asthma Which of the following are indications for glucocorticoids:
- COPD exacerbations (depending on eosinophil - asthma
counts) - COPD exacerbations
- acute gout flare - sinusitis
- croup - sore throat
- Bell's Palsy - acute gout flare
- bronchitis
- croup
- allergic rhinitis
- non-radicular lower back pain (muscular pain)
- Bell's Palsy
- acute otitis media
vasoconstrictive effects What is the potency of the topical glucocorticoids based upon?
yes Can vaccinations (including live vaccines) be given safely to patients
receiving topical corticosteroids?
Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf Pharm - Immunotherapy.pdf