Pharmacokinetics I – Flashcards Questions With Answers

Pharmacokinetics I – Flashcards Questions
With Answers

Organ distribution Intestine, Liver, Kidney, Placenta, Blood-brain barrier (BBB),
Pancreas, Colon, Testis



Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Gut
transport, Liver metabolism, Cardiac output and blood flow, Physicochemical properties of
drugs, Plasma protein binding, Tissue binding and absorption/transport



Small Intestinal transporters Almost equal number of influx and efflux transporters in both
lumen and blood sides of the small intestine



Liver transporters More influx than efflux transporters in the blood side, more efflux than
influx transporters in the bile side of the liver



Kidney transporters More influx than efflux transporters in the blood side, almost equal
numbers of influx and efflux transporters in the lumen side of the kidney



Blood-brain barrier transporters More efflux than influx transporters in the blood side




Transporters in cancer cells Maintain more nutrient concentrations than drugs