UVA BME2104 Cell and Molecular
Biology Final Exam fully solved already
passed
Microtubules - correct answer ✔✔- made of tubulin
- intracellular transport
Microfilaments - correct answer ✔✔- made of the protein called actin
- cell shape, contractility, motility
Intermediate Filaments - correct answer ✔✔- composed of many different
proteins dependent on cell type
- lend lateral strength to tissues
Tubulin - correct answer ✔✔- GTPases
- 5 possible classes (alpha, beta, gamma, delta, epsilon)
- alpha and beta exist as heterodimers
- grow as protofilaments which roll into tubes
Microtubule structure - correct answer ✔✔- protofilaments rolled up into groups
of THIRTEEN
- 24nm diameter
- polar (beta-positive end and alpha-negative end)
,In microtubules, does growth occur at the + or - end and why? - correct answer
✔✔Preferentially at the positive end, because the negative end is stabilized.
Actin structure - correct answer ✔✔- 7nm in width
- Act as ATPases
- monodimeric unlike tubulin
- actin is the most abundant of all intracellular proteins
Intermediate filaments (IF) structure - correct answer ✔✔- 8-12 nm
- stengthening & stabilizing
- NOT POLAR, therefore no molecular motors due to the fact that there is no cue
to indicate 'directionality'
Keratins (IF) - correct answer ✔✔- found in all cells, compose epithelial cells
Neurofilaments (IF) - correct answer ✔✔- stabilize nerve axons
Lamins (IF) - correct answer ✔✔- stabilize the nuclei of cells
- inner side of the nuclear envelope
Are intermediate filaments polar? - correct answer ✔✔No, they are symmetrical,
stable, and non-polar.
Muscle myosin - correct answer ✔✔- a molecular motor
- composed of 2 heavy chains each with 2 corresponding light chains
, - heavy chains wrap around each other with the heads sticking outwards
Listeriosis - correct answer ✔✔- infection of the gastrointestinal or central
nervous system
- contracted by consuming raw meat or unwashed vegetables
- symptoms are host dependent, but include: fever, diarrhea, muscle aches,
confusion, and fatigue
- invades the GI epithelium
Cytoskeleton - correct answer ✔✔- network of filamentous proteins
- microfilaments, intermediate filaments, microtubules
Cell cortex - correct answer ✔✔- dense network of actin filaments at the plasma
membrane
- provides mechanical strength, cell motility
- crosslinked by filamin, arp2/3, and alpha actinin
Spectrin - correct answer ✔✔- links to the plasma membrane via adapter proteins
- forms a 2 dimensional web that provides mechanical support for the plasma
membrane
Assembly of the cytoskeleton - correct answer ✔✔- build/degenerated by
addition or loss of monomers
- growth referred to as polymerization
Biology Final Exam fully solved already
passed
Microtubules - correct answer ✔✔- made of tubulin
- intracellular transport
Microfilaments - correct answer ✔✔- made of the protein called actin
- cell shape, contractility, motility
Intermediate Filaments - correct answer ✔✔- composed of many different
proteins dependent on cell type
- lend lateral strength to tissues
Tubulin - correct answer ✔✔- GTPases
- 5 possible classes (alpha, beta, gamma, delta, epsilon)
- alpha and beta exist as heterodimers
- grow as protofilaments which roll into tubes
Microtubule structure - correct answer ✔✔- protofilaments rolled up into groups
of THIRTEEN
- 24nm diameter
- polar (beta-positive end and alpha-negative end)
,In microtubules, does growth occur at the + or - end and why? - correct answer
✔✔Preferentially at the positive end, because the negative end is stabilized.
Actin structure - correct answer ✔✔- 7nm in width
- Act as ATPases
- monodimeric unlike tubulin
- actin is the most abundant of all intracellular proteins
Intermediate filaments (IF) structure - correct answer ✔✔- 8-12 nm
- stengthening & stabilizing
- NOT POLAR, therefore no molecular motors due to the fact that there is no cue
to indicate 'directionality'
Keratins (IF) - correct answer ✔✔- found in all cells, compose epithelial cells
Neurofilaments (IF) - correct answer ✔✔- stabilize nerve axons
Lamins (IF) - correct answer ✔✔- stabilize the nuclei of cells
- inner side of the nuclear envelope
Are intermediate filaments polar? - correct answer ✔✔No, they are symmetrical,
stable, and non-polar.
Muscle myosin - correct answer ✔✔- a molecular motor
- composed of 2 heavy chains each with 2 corresponding light chains
, - heavy chains wrap around each other with the heads sticking outwards
Listeriosis - correct answer ✔✔- infection of the gastrointestinal or central
nervous system
- contracted by consuming raw meat or unwashed vegetables
- symptoms are host dependent, but include: fever, diarrhea, muscle aches,
confusion, and fatigue
- invades the GI epithelium
Cytoskeleton - correct answer ✔✔- network of filamentous proteins
- microfilaments, intermediate filaments, microtubules
Cell cortex - correct answer ✔✔- dense network of actin filaments at the plasma
membrane
- provides mechanical strength, cell motility
- crosslinked by filamin, arp2/3, and alpha actinin
Spectrin - correct answer ✔✔- links to the plasma membrane via adapter proteins
- forms a 2 dimensional web that provides mechanical support for the plasma
membrane
Assembly of the cytoskeleton - correct answer ✔✔- build/degenerated by
addition or loss of monomers
- growth referred to as polymerization
