Genetics Final Exam: Structured for Success with
Questions Guaranteed to Enhance Your Academic
Performance
The components of a chromosome include one long DNA molecule and:
A) phospholipids
B) proteins
C) carbohydrates
D) steroids
E) RNA - CORRECT ANSWER- -B) proteins
By weight, chromatin consists roughly of:
A) 1/3 DNA, 1/3 histones, & 1/3 nonhistones
B) 1/3 DNA, 2/3 acidic proteins
C) 1/3 DNA, 1/3 histones, & 1/3 basic proteins
D) 1/4 DNA, 1/4 RNA, 1/4 histones, 1/4 nonhistones - CORRECT ANSWER- -A) 1/3 DNA, 1/3
histones, & 1/3 nonhistones
Histones and DNA have a strong attraction for each other because:
A) DNA is positively charged and histones are negatively charged.
B) both DNA and proteins are hydrophobic.
C) DNA is negatively charged and histones are positively charged
D) like substances share common charges
.E) none of the above - CORRECT ANSWER- -C) DNA is negatively charged and histones are
positively charged
The enzyme that some organisms use to replicate DNA at the 5' ends of chromosomes is
called:
,A) DNA polymerase
B) telomerase
C) DNA ligase
D) replicase - CORRECT ANSWER- -B) telomerase
Which of the following is not usually seen when a cell loses telomerase activity?
A) Telomeres shorten slightly with each cell division.
B) After 30-50 divisions cells show signs of senescence and then die.
C) In the immune system certain capacity for protection is gradually lost.
D) Many normal somatic cells gain the ability to divide indefinitely - CORRECT ANSWER- -
D) Many normal somatic cells gain the ability to divide indefinitely
The chromosome can be considered a dynamic organelle for _______________ of DNA.
A) expression
B) segregation
C) replication
D) packaging
E) all of the above - CORRECT ANSWER- -E) All of the above
Which of the following is not a role ascribed to nonhistone proteins found in chromatin?
A) structural
B) replication
C) chromosome segregation
D) nucleosome packers - CORRECT ANSWER- -D) nucleosome packers
, Histones appear to have a singular role in the packaging of DNA. The nonhistone proteins in
chromatin have which of the following functions?
A) different functions for different tissues, such as tissue-specific transcription factors
B) activity at different moments in the life cycle
C) centromere function activity
D) all of the above - CORRECT ANSWER- -D) All of the above
The first level of compaction of DNA consists of:
A) DNA winding around histones to form small nucleosomes.
B) tight coiling of DNA with nucleosomes into higher order structures.
C) high level compaction into metaphase-type chromosomes.
D) histone, DNA, and nonhistone covalent bonding - CORRECT ANSWER- -A) DNA winding
around histones to form small nucleosomes
An electron micrograph of chromatin, which looks like a bead on a string,
allowsmeasurement of structural dimensions. The beads appear to have a diameter of
about ________ Å and the string a diameter of about ________ Å.
A) 20, 100
B) 20, 0.1
C) 100, 20
D) 120, 100 - CORRECT ANSWER- -C) 100, 20
Nucleosomal chromatin with a diameter of 100Å supercoils into a 300Å superhelix.
Thehistone that appears to be responsible for this compaction is:
A) H4.
B) H3.
C) H2.
Questions Guaranteed to Enhance Your Academic
Performance
The components of a chromosome include one long DNA molecule and:
A) phospholipids
B) proteins
C) carbohydrates
D) steroids
E) RNA - CORRECT ANSWER- -B) proteins
By weight, chromatin consists roughly of:
A) 1/3 DNA, 1/3 histones, & 1/3 nonhistones
B) 1/3 DNA, 2/3 acidic proteins
C) 1/3 DNA, 1/3 histones, & 1/3 basic proteins
D) 1/4 DNA, 1/4 RNA, 1/4 histones, 1/4 nonhistones - CORRECT ANSWER- -A) 1/3 DNA, 1/3
histones, & 1/3 nonhistones
Histones and DNA have a strong attraction for each other because:
A) DNA is positively charged and histones are negatively charged.
B) both DNA and proteins are hydrophobic.
C) DNA is negatively charged and histones are positively charged
D) like substances share common charges
.E) none of the above - CORRECT ANSWER- -C) DNA is negatively charged and histones are
positively charged
The enzyme that some organisms use to replicate DNA at the 5' ends of chromosomes is
called:
,A) DNA polymerase
B) telomerase
C) DNA ligase
D) replicase - CORRECT ANSWER- -B) telomerase
Which of the following is not usually seen when a cell loses telomerase activity?
A) Telomeres shorten slightly with each cell division.
B) After 30-50 divisions cells show signs of senescence and then die.
C) In the immune system certain capacity for protection is gradually lost.
D) Many normal somatic cells gain the ability to divide indefinitely - CORRECT ANSWER- -
D) Many normal somatic cells gain the ability to divide indefinitely
The chromosome can be considered a dynamic organelle for _______________ of DNA.
A) expression
B) segregation
C) replication
D) packaging
E) all of the above - CORRECT ANSWER- -E) All of the above
Which of the following is not a role ascribed to nonhistone proteins found in chromatin?
A) structural
B) replication
C) chromosome segregation
D) nucleosome packers - CORRECT ANSWER- -D) nucleosome packers
, Histones appear to have a singular role in the packaging of DNA. The nonhistone proteins in
chromatin have which of the following functions?
A) different functions for different tissues, such as tissue-specific transcription factors
B) activity at different moments in the life cycle
C) centromere function activity
D) all of the above - CORRECT ANSWER- -D) All of the above
The first level of compaction of DNA consists of:
A) DNA winding around histones to form small nucleosomes.
B) tight coiling of DNA with nucleosomes into higher order structures.
C) high level compaction into metaphase-type chromosomes.
D) histone, DNA, and nonhistone covalent bonding - CORRECT ANSWER- -A) DNA winding
around histones to form small nucleosomes
An electron micrograph of chromatin, which looks like a bead on a string,
allowsmeasurement of structural dimensions. The beads appear to have a diameter of
about ________ Å and the string a diameter of about ________ Å.
A) 20, 100
B) 20, 0.1
C) 100, 20
D) 120, 100 - CORRECT ANSWER- -C) 100, 20
Nucleosomal chromatin with a diameter of 100Å supercoils into a 300Å superhelix.
Thehistone that appears to be responsible for this compaction is:
A) H4.
B) H3.
C) H2.
