PCOL 838 Final Exam 2025 Graded A+
Questions with 100% Correct Answers
What kind of binding contributes to affinity between antigen/antibody? - non-covalent (reversible)
-electrostatic
-van der waal
-hydrogen
-hydrophobic
What is the process of recombination for light and heavy chains? - -light chains: germline DNA,
somatic recombo, VJ joined transcription, splicing, translation
-heavy chains: germline DNA, somatic recombo, DJ joined, somatic recombo, VDJ joined,
transcription, splicing, translation
Compare innate immunity vs adaptive immunity - -innate: fixed, rapid, limited # of specificities
improved during response
-adaptive: slow, variable, highly specificities improved during response
What are some examples of innate immunity? - -anatomical barriers: physical and chemical barriers
-phagocytic cells: patrol bloodstream and tissue and rush to site of infection
-complement: direct activities of some phagocytic cells
What are the adaptive immune organs? - spleen, thymus
What do red blood cells do? - transport O2 and CO2
What do neutrophils do? - phagocytose and destroy invading bacteria
What do eosinophils do? - destroy large parasites and modulate allergic inflammatory responses
, What do basophils do? - release histamine in certain immune reactions
What do monocytes do? - become tissue macrophages which phagocytose and digest invading
microorganisms and foreign bodies as well as damaged and senescent cells
What do B cells do? - make antibodies
What do T cells do? - kill virus-infected cells and regulate activities of other leukocytes
What do NK cells do? - kill virus-infected cells and some tumor cells
What do platelets do? - initiate blood clotting
Where do T cells mature? - thymus
What are T cells the main constituent of? - lymphocyte population
What is the diversity and specificity of T cells determined by? - -TCR/CD profile
-cytokine profile
Where do lymph nodes capture antigens from? - epithelium and connective tissue
Where are blood-borne antigens captured? - in spleen and captured by antigen-presenting cells
How are antigens presented to T-cells? - can only bind to protein antigen that has been processed
into small peptide and packaged inside MHC...MHC restricted!
How are antigens presented to B-cells? - can bind free floating antigen that happens to brush against
it
What needs to be the relationship between the T cell receptor and MHC? - each TCR is pre-designed
to have affinity for a particular antigen (ex. T cell receptor from individual A will only recognize
antigens presented by MHC from individual A)
Questions with 100% Correct Answers
What kind of binding contributes to affinity between antigen/antibody? - non-covalent (reversible)
-electrostatic
-van der waal
-hydrogen
-hydrophobic
What is the process of recombination for light and heavy chains? - -light chains: germline DNA,
somatic recombo, VJ joined transcription, splicing, translation
-heavy chains: germline DNA, somatic recombo, DJ joined, somatic recombo, VDJ joined,
transcription, splicing, translation
Compare innate immunity vs adaptive immunity - -innate: fixed, rapid, limited # of specificities
improved during response
-adaptive: slow, variable, highly specificities improved during response
What are some examples of innate immunity? - -anatomical barriers: physical and chemical barriers
-phagocytic cells: patrol bloodstream and tissue and rush to site of infection
-complement: direct activities of some phagocytic cells
What are the adaptive immune organs? - spleen, thymus
What do red blood cells do? - transport O2 and CO2
What do neutrophils do? - phagocytose and destroy invading bacteria
What do eosinophils do? - destroy large parasites and modulate allergic inflammatory responses
, What do basophils do? - release histamine in certain immune reactions
What do monocytes do? - become tissue macrophages which phagocytose and digest invading
microorganisms and foreign bodies as well as damaged and senescent cells
What do B cells do? - make antibodies
What do T cells do? - kill virus-infected cells and regulate activities of other leukocytes
What do NK cells do? - kill virus-infected cells and some tumor cells
What do platelets do? - initiate blood clotting
Where do T cells mature? - thymus
What are T cells the main constituent of? - lymphocyte population
What is the diversity and specificity of T cells determined by? - -TCR/CD profile
-cytokine profile
Where do lymph nodes capture antigens from? - epithelium and connective tissue
Where are blood-borne antigens captured? - in spleen and captured by antigen-presenting cells
How are antigens presented to T-cells? - can only bind to protein antigen that has been processed
into small peptide and packaged inside MHC...MHC restricted!
How are antigens presented to B-cells? - can bind free floating antigen that happens to brush against
it
What needs to be the relationship between the T cell receptor and MHC? - each TCR is pre-designed
to have affinity for a particular antigen (ex. T cell receptor from individual A will only recognize
antigens presented by MHC from individual A)
