NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS QUESTIONS WITH CORRECT ANSWERS 2025

NR565 ADVANCED PHARMACOLOGY
FUNDAMENTALS QUESTIONS WITH
CORRECT ANSWERS 2025
PharmacokineticsN-NCORRECTNANSWERN-
TheNprocessNbyNwhichNdrugsNareNabsorbed,NdistributedNwithinNtheNbody,Nmetabolized,NandNexcreted.



PharmacodynamicsN-NCORRECTNANSWERN-TheNstudyNofNwhatNtheNdrugNdoesNtoNtheNbody



FactorsNAffectingNDrugNAbsorptionN-NCORRECTNANSWERN-RateNofNdissolution

SurfaceNarea

BloodNflow

LipidNsolubility

pHNpartitioning



FactorsNAffectingNDrugNDistributionN-NCORRECTNANSWERN-BloodNflowNtoNtissues

AbilityNtoNexitNtheNvascularNsystem

Blood-brainNbarrier

Protein-bindingNcapacity



XenobioticsN-NCORRECTNANSWERN-
substancesNthatNareNforeignNtoNtheNbody,NusuallyNsyntheticNchemicalNcompounds;NmedicationsNareNaNcom
monNexample



CytochromeNP450N(CYP450)N-NCORRECTNANSWERN-xenobiotic-
metabolizingNenzymesNnecessaryNforNtheNproductionNofNcholesterolNandNsteroidsNandNtheNdetoxificationN
ofNchemicalsNandNdrugNmetabolism.



FunctionNofNCytochromeNP450N(CYP450)N-NCORRECTNANSWERN-
responsibleNforNphaseN1NmetabolismNinNwhichNdrugsNareNoxidized,Nreduced,NorNhydrolyzed

,PhaseN1NMetabolismNofNDrugsNviaNP450N-NCORRECTNANSWERN-Oxidation;NReduction;NHydrolysis



ThreeNpossibleNoutcomesNofNphaseN1NdrugNmetabolism.N-NCORRECTNANSWERN--
DrugNbecomesNcompletelyNinactive



-DrugNbecomesNpartiallyNinactiveNbutNoneNorNmoreNmetabolitesNremainNactive



-OriginalNdrugNisNnotNpharmacologicallyNactiveNbutNoneNmetaboliteNremainsNactive



CYP450NInducersN-NCORRECTNANSWERN-
MedicationsNthatNcanNincreaseNtheNrateNofNanotherNdrug'sNmetabolismNbyNelevatingNCYP450NenzymeNacti
vityNviaNincreasingNenzymeNsynthesis.NdecreasingNtheNconcentrationNofNtheN"parentNdrug"



CYP450NInducerNMedicationsN-NCORRECTNANSWERN-CRAPGPS

Carbamazepine

Rifampin

Alcohol

Phenytoin

Griseofulvin

Phenobarbital

Sulfonylureas



CYP450NInhibitorsN-NCORRECTNANSWERN-
MedicationsNthatNinhibitNtheNmetabolicNactivityNofNoneNorNmoreNofNtheNCYP450Nenzymes.NHigherNriskNforN
toxicity;NprolongsNtheNpharmacologicalNeffectNofNtheN"parentNdrug".



CYP450NInhibitorNMedicationsN-NCORRECTNANSWERN-VISACKGQ

Valproate

Isoniazid

Sulfonamides

,Amiodarone

Chloramphenicol

Ketoconazole

GrapefruitNJuice

Quinidine



BeersNCriteriaN-NCORRECTNANSWERN--potentiallyNInappropriateNMedicationN(PIM)NuseNinNolderNadults

-potentiallyNInappropriateNMedicationN(PIM)NuseNinNolderNadultsNdueNtoNmedication-
diseaseNorNmedication-syndromeNinteractionsNthatNmayNexacerbateNtheNdiseaseNorNsyndrome

-medicationsNtoNbeNusedNcautiouslyNinNolderNadults

-clinicallyNsignificantNdrugNinteractionsNthatNshouldNbeNavoidedNinNolderNadults

-
medicationsNtoNbeNavoidedNorNdosageNdecreasedNinNtheNpresenceNofNimpairedNkidneyNfunctionNinNolderNa
dults



PharmacokineticNInteractionsN-NCORRECTNANSWERN-
whenNoneNmedicationNsystemicallyNaltersNtheNpotencyNofNanotherNmedication.



AbsorptionNInteractionN-NCORRECTNANSWERN-
resultNofNaNchangeNdueNtoNoneNmedication'sNeffectNonNanotherNmedication'sNrouteNofNentryNintoNtheNbod
y.



DistributionNInteractionN-NCORRECTNANSWERN-
causedNbyNtheNamountNofNunbound/freeNmedicationsNavailableNatNtheNvariousNtargetNsites.



MetabolismNInteractionN-NCORRECTNANSWERN-
concentrationNofNtheNmedicationNafterNbiotransformationNintoNactiveNandNinactiveNmetabolitesNinNhigherN
orNlowerNthanNexpected.



EliminationNInteractionN-NCORRECTNANSWERN-
theNbody'sNabilityNtoNeliminateNmedicationsNinNpureNformNorNbyNalteringNaNmetaboliteNfromNtheNbody.

, PharmacodynamicNInteractionsN-NCORRECTNANSWERN-
doesNnotNalterNorNimpactNabsorption,Ndistribution,Nmetabolism,NorNeliminationNbecauseNofNtheNoneNmedi
cation'sNabilityNtoNmanipulateNtheNeffectNofNanotherNmedicationNatNitsNsiteNofNaction



PracticeNAuthorityN-NCORRECTNANSWERN-
refersNtoNtheNnurseNpractitioner'sNabilityNtoNpracticeNwithoutNphysicianNoversight



prescriptiveNauthorityN-NCORRECTNANSWERN-
refersNtoNtheNnurseNpractitioner'sNauthorityNtoNprescribeNmedications.



Full-practiceNscopeN-NCORRECTNANSWERN-
NurseNpractitionersNhaveNtheNautonomyNtoNevaluateNpatients,Ndiagnose,NorderNandNinterpretNtests,Ninitiat
eNandNmanageNtreatmentsNandNprescribeNmedications,NincludingNcontrolledNsubstancesNwithoutNphysicia
nNoversight.



Reduced-practiceNscopeN-NCORRECTNANSWERN-
NurseNpractitionersNareNlimitedNinNatNleastNoneNelementNofNpractice.NTheNstateNrequiresNaNformalNcollabor
ativeNagreementNwithNanNoutsideNhealthNdisciplineNforNtheNnurseNpractitionerNtoNprovideNpatientNcare.



RestrictedNpracticeNscopeN-NCORRECTNANSWERN-
NurseNpractitionersNareNlimitedNinNatNleastNoneNelementNofNpracticeNbyNrequiringNsupervision,Ndelegation,
NorNteamNmanagementNbyNanNoutsideNhealthNdisciplineNforNtheNnurseNpractitionerNtoNprovideNpatientNcar

e.



DrugsNthatNcannotNbeNorderedNviaNE-ScriptN-NCORRECTNANSWERN-DEANScheduledNDrugs



DrugsNthatNcannotNbeNprescribedNorNrefilledNviaNphoneN-NCORRECTNANSWERN-ScheduleNIINdrugs



AcuteNPainN-NCORRECTNANSWERN-
AnNoccurrenceNofNfewerNthanNthreeNmonthsNandNisNoftenNprecipitatedNbyNtraumaNandNacuteNmedicalNcon
ditionsNorNtreatment.



TypesNofNAcuteNPainN-NCORRECTNANSWERN-ReferredNPain

AcuteNSomaticNPain