NR565 WEEK 7 & 8 STUDY GUIDE QUESTIONS
WITH CORRECT ANSWERS 2025
AntacidsMPharmacodynamicsM-MCORRECTMANSWERM-NeutralMsaltsMorMlow-
acidicMsaltsMareMproducedMwhenMgastricMacidMreactsMwithMantacids.MTheMdestructionMofMtheMstomach'sM
wallMisMloweredMwhenMtheseMdrugsMneutralizeMtheMacidMinMthisMlocation.MWithMantacidMuse,MpepsinMacti
vityMmayMbeMdecreasedMifMtheMgastricMpHMisMincreasedMaboveM5.MAdditionally,MprostaglandinMproduction
MisMacceleratedMwithMantacidMuse,MwhichMcanMstrengthenMmucosalMprotection.MItMisMimportantMtoMnoteMt
hatMantacidsMdoMnotMplaceMaMprotectiveMbarrierMorMcoatingMoverMtheMulcerMfromMpepsinMorMacid.MAntaci
dMabsorptionMisMpoor,MwithMtheMexceptionMofMsodiumMbicarbonate,Mthus,MsystemicMpHMisMnotMmodified.
AntacidsMPharmacokineticsM-MCORRECTMANSWERM-renallyMeliminated
AntacidsMPharmacotherapeuticsM-MCORRECTMANSWERM-
severeMrenalMfailure,MandMGIMobstruction.MTheMfourMbasicMantacidMmechanismsMthatMcauseMinteractionsM
are:MAbsorptionMofMotherMdrugsMtoMantacids,MwhichMreducesMtheMabilityMofMtheMotherMdrugMtoMbeMabsor
bedMintoMtheMbody.MChelation,MwhichMisMtheMchemicalMinactivationMofMotherMdrugsMthatMproducesMinsol
ubleMcomplexesMIncreasedMstomachMpH,MwhichMincreasesMtheMabsorptionMofMbasicMdrugsMandMdecreases
MtheMabsorptionMofMacidicMdrugs.MIncreasedMurinaryMpH,MwhichMincreasesMtheMexcretionMofMacidicMdrugs
MandMdecreasesMtheMexcretionMofMbasicMdrugs.MMostMdrugsMareMeitherMweakMacidsMorMweakMbases.MTher
efore,MpHMconditionsMinMbothMtheMGIMandMurinaryMtractsMwillMaffectMtheMextentMtoMwhichMdrugMmolecule
sMareMabsorbed.MBenzodiazepines,Msulfonylureas,MsympathomimeticMacid,MandMvalproicMacidMareMdrugsMt
hatMmayMbeMchemicallyMenhancedMbyMantacidMpresenceM(dueMtoMtheMeffectsMofMpH).MTheMefficacyMofMot
herMdrugs,MsuchMasManticonvulsantsM(e.g.,MphenytoinMsodium),MisMreducedMwhenMantacidsMareMpresentM
becauseMantacidsMimpedeMtheMGIMabsorptionMofMtheMdrugs.MWhenMtheMquinoloneMantibioticsM(ciproflox
acin,Mlevofloxacin,Mmoxifloxacin),MwhichMareMorallyMadministeredMtoMtreatMseriousMinfections,MareMgivenM
withMantacids,MsevereMharmMmayMoccurMtoMaMpatientMbecauseMantacidsMcanMreduceMabsorptionMofMtheM
antibioticsMbyMmoreMthanM50%.
AntacidsMClinicalMindicationsM&MdosingM-MCORRECTMANSWERM-
PepticMulcerMdiseaseM(PUD)MisMtheMprimaryMindicationMforMantacidMuse.MTheMhealingMratesMareMequalMtoM
thatMofMH2RAs.MInMtheMpast,MantacidsMwereMprimarilyMusedMforMantiulcerMtherapy;Mhowever,MnewerMopti
onsMhaveMreplacedMtheseMdrugsM(H2RAs,MPPIs,Msucralfate)MthatMareMjustMasMbeneficialMandMeffective,Mwit
hMeasierMadministration,MandMcauseMfewerMsideMeffects.MAspirationMpneumonitisMisMpreventedMbyMantaci
dMadministrationMbeforeManesthesia.MInMaddition,MmedicationMcanMbeMusedMtoMpreventMandMtreatMstress
-
inducedMulcers.MGERDMpatientsMcanMhaveMreliefMfromMantacidMuse,MbutMunfortunately,MhealingMisMnotMac
celerated.MEvenMthoughMantacidMuseMisMgenerallyMusedMbyMtheMpublic,MthereMareMnoMstudiesMthatMshowM
theMeffectivenessMofMantacidMuseMforMsymptomsMsuchMasMdyspepsia,Mheartburn,MandMindigestion.MItMisMe
ssentialMforMtheMnurseMtoMadministerMantacidsMappropriately,MfollowMaccurateMdosingMparameters,MandM
properlyMmonitorMlabMvaluesMcloselyMtoMavoidMadverseMeffects.MBeforeMadministering,MshakeMsuspension
, MwellMandMfollowMwithMwater.MDueMtoMtheMdelayMinMotherMdrugMabsorption,MantacidMadministrationMsho
uldMbeMavoidedMwithMotherMoralMdrugs.MAntacidsMshouldMnotMbeMgivenMwithMtetracycline,Mdigoxin,MorMqu
inidine,MbecauseMitMbindsMwithMandMinactivatesMmostMofMtheMdrug.MTherefore,MantacidsMshouldMbeMgiven
M1MtoM2MhoursMafterMotherMmedications.MMonitorMelectrolytes,MurinaryMpH,Mcalcium,MandMphosphateMlev
elsMafterMantacidMadministration.MDrugM(PregnancyMCategory)MaluminumMhydroxideM(Amphojel)M(A)Malu
minumMhydroxideMandMmagnesiumMhydroxideM(Maalox,MMylanta)M(A)McalciumMcarbonateM(Tums)M(A)Mm
agnesiumMhydroxideM(milkMofMmagnesia)M(A)MPharmacologicMClassMAluminum-
containingMantacidMCombinationMantacidMCalcium-containingMantacidMMagnesium-
containingMantacidMUsualMAdultMDosageMRangeMAdultMPO:M600-1500MmgM3-6MtimesMperMdayMAdultM400-
2400MmgM3-6MtimesMper
AntacidsMADRsMandMcontraindicationsM-MCORRECTMANSWERM-
MagnesiumMcontainingMproducts,MespeciallyMMilkMofMMagnesia,McanMcauseMdiarrhea.MConstipationMcanM
resultMfromMbothMtheMaluminum-MandMcalcium-
containingMformulations.MTheMcombinationMofMaluminumMandMmagnesiumMhydroxideMisMfavoredMbecaus
eMtheMsideMeffectsMareMthenMdecreased.MKidneyMstonesMcanMdevelopMfromMtheMcalciumMproducts.MSyste
micMalkalosisMcanMresultMfromMextremeMantacidMuse,MwhichMprimarilyMoccursMwithMsodiumMbicarbonateM
use.MExcessMsodium,MwhichMisMpresentMinMsomeMantacidMpreparations,McanMworsenMhypertensionMandMh
eartMfailure.MPatientsMwithMtheseMconditionsMshouldMavoidMtheMformulationsMthatMhaveMhighMsodiumMco
ntent.MReboundMhyperacidity,MorMacidMreboundMisManMadverseMeffectMtheMpatientMexperiencesMwithMtheM
discontinuationMofMantacids.MThisMadverseMeffectMmainlyMoccursMwithMcalcium-
containingMproducts.MSeriousMdiseases,MsuchMasMcancerMorMbleedingMulcers,MmayMbeMmaskedMwithMlong-
termMantacidMuse.MTherefore,MongoingMsymptomsMmustMbeMcheckedMandMevaluatedMbecauseMotherMme
dicalMinterventionsMmayMbeMrequired.
AntacidsMPatientMEducationM-MCORRECTMANSWERM-
ProperMpatientMeducationMregardingMadministrationMofMantacidsMisMimportantMforMtheMnurseMandMpatien
t.MBelowMareMsomeMkeyMpointsMtoMincludeMwithMtheMpatientMwhenMteaching:MEmphasizeMtheMimportanc
eMofMtakingMantacidsMcorrectly.MTabletsMthatMareMchewableMmustMbeMcompletelyMchewedMandMfollowedM
withMwater.MDrinkM2-
4MouncesMofMwaterMafterMtakingMtheMliquidMantacid.MGastricMemptyingMtimeMincreasesMwhenMtheMamoun
tMofMwaterMwithMantacidsMincreases.MReportMpain,Mcoughing,MorMvomitingMofMblood.MTakeMtheMantacidM1M
toM3MhoursMafterMmealsMandMatMbedtime.MTheMpatientMdoesMnotMneedMtoMtakeMantacidsMatMmealtime;Mth
eyMslowMgastricMemptyingMtime,McausingMincreasedMGIMactivityMandMgastricMsecretions.MTakingManMunlimi
tedMamountMofMtheMantacidMisMcontraindicated.MDoMnotMtakeMtheMantacidsMwithMmilkMorMfoodsMhighMinMv
itaminMD.MAvoidMtakingMantacidsMwithinM1MtoM2MhoursMofMotherMoralMmedications,MbecauseMtheyMmayMin
terfereMwithMabsorption.MFollowMaMsodium-
restrictedMdietMandMmonitorMantacidMlabelsMforMsodiumMcontent.CMonsultMwithMtheirMhealthMcareMprovid
erMbeforeMtakingMantacidsMforMlongerMthanM2Mweeks.MGuideMpatientMonMtheMuseMofMrelaxationMtechniqu
es.
WITH CORRECT ANSWERS 2025
AntacidsMPharmacodynamicsM-MCORRECTMANSWERM-NeutralMsaltsMorMlow-
acidicMsaltsMareMproducedMwhenMgastricMacidMreactsMwithMantacids.MTheMdestructionMofMtheMstomach'sM
wallMisMloweredMwhenMtheseMdrugsMneutralizeMtheMacidMinMthisMlocation.MWithMantacidMuse,MpepsinMacti
vityMmayMbeMdecreasedMifMtheMgastricMpHMisMincreasedMaboveM5.MAdditionally,MprostaglandinMproduction
MisMacceleratedMwithMantacidMuse,MwhichMcanMstrengthenMmucosalMprotection.MItMisMimportantMtoMnoteMt
hatMantacidsMdoMnotMplaceMaMprotectiveMbarrierMorMcoatingMoverMtheMulcerMfromMpepsinMorMacid.MAntaci
dMabsorptionMisMpoor,MwithMtheMexceptionMofMsodiumMbicarbonate,Mthus,MsystemicMpHMisMnotMmodified.
AntacidsMPharmacokineticsM-MCORRECTMANSWERM-renallyMeliminated
AntacidsMPharmacotherapeuticsM-MCORRECTMANSWERM-
severeMrenalMfailure,MandMGIMobstruction.MTheMfourMbasicMantacidMmechanismsMthatMcauseMinteractionsM
are:MAbsorptionMofMotherMdrugsMtoMantacids,MwhichMreducesMtheMabilityMofMtheMotherMdrugMtoMbeMabsor
bedMintoMtheMbody.MChelation,MwhichMisMtheMchemicalMinactivationMofMotherMdrugsMthatMproducesMinsol
ubleMcomplexesMIncreasedMstomachMpH,MwhichMincreasesMtheMabsorptionMofMbasicMdrugsMandMdecreases
MtheMabsorptionMofMacidicMdrugs.MIncreasedMurinaryMpH,MwhichMincreasesMtheMexcretionMofMacidicMdrugs
MandMdecreasesMtheMexcretionMofMbasicMdrugs.MMostMdrugsMareMeitherMweakMacidsMorMweakMbases.MTher
efore,MpHMconditionsMinMbothMtheMGIMandMurinaryMtractsMwillMaffectMtheMextentMtoMwhichMdrugMmolecule
sMareMabsorbed.MBenzodiazepines,Msulfonylureas,MsympathomimeticMacid,MandMvalproicMacidMareMdrugsMt
hatMmayMbeMchemicallyMenhancedMbyMantacidMpresenceM(dueMtoMtheMeffectsMofMpH).MTheMefficacyMofMot
herMdrugs,MsuchMasManticonvulsantsM(e.g.,MphenytoinMsodium),MisMreducedMwhenMantacidsMareMpresentM
becauseMantacidsMimpedeMtheMGIMabsorptionMofMtheMdrugs.MWhenMtheMquinoloneMantibioticsM(ciproflox
acin,Mlevofloxacin,Mmoxifloxacin),MwhichMareMorallyMadministeredMtoMtreatMseriousMinfections,MareMgivenM
withMantacids,MsevereMharmMmayMoccurMtoMaMpatientMbecauseMantacidsMcanMreduceMabsorptionMofMtheM
antibioticsMbyMmoreMthanM50%.
AntacidsMClinicalMindicationsM&MdosingM-MCORRECTMANSWERM-
PepticMulcerMdiseaseM(PUD)MisMtheMprimaryMindicationMforMantacidMuse.MTheMhealingMratesMareMequalMtoM
thatMofMH2RAs.MInMtheMpast,MantacidsMwereMprimarilyMusedMforMantiulcerMtherapy;Mhowever,MnewerMopti
onsMhaveMreplacedMtheseMdrugsM(H2RAs,MPPIs,Msucralfate)MthatMareMjustMasMbeneficialMandMeffective,Mwit
hMeasierMadministration,MandMcauseMfewerMsideMeffects.MAspirationMpneumonitisMisMpreventedMbyMantaci
dMadministrationMbeforeManesthesia.MInMaddition,MmedicationMcanMbeMusedMtoMpreventMandMtreatMstress
-
inducedMulcers.MGERDMpatientsMcanMhaveMreliefMfromMantacidMuse,MbutMunfortunately,MhealingMisMnotMac
celerated.MEvenMthoughMantacidMuseMisMgenerallyMusedMbyMtheMpublic,MthereMareMnoMstudiesMthatMshowM
theMeffectivenessMofMantacidMuseMforMsymptomsMsuchMasMdyspepsia,Mheartburn,MandMindigestion.MItMisMe
ssentialMforMtheMnurseMtoMadministerMantacidsMappropriately,MfollowMaccurateMdosingMparameters,MandM
properlyMmonitorMlabMvaluesMcloselyMtoMavoidMadverseMeffects.MBeforeMadministering,MshakeMsuspension
, MwellMandMfollowMwithMwater.MDueMtoMtheMdelayMinMotherMdrugMabsorption,MantacidMadministrationMsho
uldMbeMavoidedMwithMotherMoralMdrugs.MAntacidsMshouldMnotMbeMgivenMwithMtetracycline,Mdigoxin,MorMqu
inidine,MbecauseMitMbindsMwithMandMinactivatesMmostMofMtheMdrug.MTherefore,MantacidsMshouldMbeMgiven
M1MtoM2MhoursMafterMotherMmedications.MMonitorMelectrolytes,MurinaryMpH,Mcalcium,MandMphosphateMlev
elsMafterMantacidMadministration.MDrugM(PregnancyMCategory)MaluminumMhydroxideM(Amphojel)M(A)Malu
minumMhydroxideMandMmagnesiumMhydroxideM(Maalox,MMylanta)M(A)McalciumMcarbonateM(Tums)M(A)Mm
agnesiumMhydroxideM(milkMofMmagnesia)M(A)MPharmacologicMClassMAluminum-
containingMantacidMCombinationMantacidMCalcium-containingMantacidMMagnesium-
containingMantacidMUsualMAdultMDosageMRangeMAdultMPO:M600-1500MmgM3-6MtimesMperMdayMAdultM400-
2400MmgM3-6MtimesMper
AntacidsMADRsMandMcontraindicationsM-MCORRECTMANSWERM-
MagnesiumMcontainingMproducts,MespeciallyMMilkMofMMagnesia,McanMcauseMdiarrhea.MConstipationMcanM
resultMfromMbothMtheMaluminum-MandMcalcium-
containingMformulations.MTheMcombinationMofMaluminumMandMmagnesiumMhydroxideMisMfavoredMbecaus
eMtheMsideMeffectsMareMthenMdecreased.MKidneyMstonesMcanMdevelopMfromMtheMcalciumMproducts.MSyste
micMalkalosisMcanMresultMfromMextremeMantacidMuse,MwhichMprimarilyMoccursMwithMsodiumMbicarbonateM
use.MExcessMsodium,MwhichMisMpresentMinMsomeMantacidMpreparations,McanMworsenMhypertensionMandMh
eartMfailure.MPatientsMwithMtheseMconditionsMshouldMavoidMtheMformulationsMthatMhaveMhighMsodiumMco
ntent.MReboundMhyperacidity,MorMacidMreboundMisManMadverseMeffectMtheMpatientMexperiencesMwithMtheM
discontinuationMofMantacids.MThisMadverseMeffectMmainlyMoccursMwithMcalcium-
containingMproducts.MSeriousMdiseases,MsuchMasMcancerMorMbleedingMulcers,MmayMbeMmaskedMwithMlong-
termMantacidMuse.MTherefore,MongoingMsymptomsMmustMbeMcheckedMandMevaluatedMbecauseMotherMme
dicalMinterventionsMmayMbeMrequired.
AntacidsMPatientMEducationM-MCORRECTMANSWERM-
ProperMpatientMeducationMregardingMadministrationMofMantacidsMisMimportantMforMtheMnurseMandMpatien
t.MBelowMareMsomeMkeyMpointsMtoMincludeMwithMtheMpatientMwhenMteaching:MEmphasizeMtheMimportanc
eMofMtakingMantacidsMcorrectly.MTabletsMthatMareMchewableMmustMbeMcompletelyMchewedMandMfollowedM
withMwater.MDrinkM2-
4MouncesMofMwaterMafterMtakingMtheMliquidMantacid.MGastricMemptyingMtimeMincreasesMwhenMtheMamoun
tMofMwaterMwithMantacidsMincreases.MReportMpain,Mcoughing,MorMvomitingMofMblood.MTakeMtheMantacidM1M
toM3MhoursMafterMmealsMandMatMbedtime.MTheMpatientMdoesMnotMneedMtoMtakeMantacidsMatMmealtime;Mth
eyMslowMgastricMemptyingMtime,McausingMincreasedMGIMactivityMandMgastricMsecretions.MTakingManMunlimi
tedMamountMofMtheMantacidMisMcontraindicated.MDoMnotMtakeMtheMantacidsMwithMmilkMorMfoodsMhighMinMv
itaminMD.MAvoidMtakingMantacidsMwithinM1MtoM2MhoursMofMotherMoralMmedications,MbecauseMtheyMmayMin
terfereMwithMabsorption.MFollowMaMsodium-
restrictedMdietMandMmonitorMantacidMlabelsMforMsodiumMcontent.CMonsultMwithMtheirMhealthMcareMprovid
erMbeforeMtakingMantacidsMforMlongerMthanM2Mweeks.MGuideMpatientMonMtheMuseMofMrelaxationMtechniqu
es.
