Test Bank For Pharmacology: An Introduction 7th Edition By He
h h h h h h h h h
nry Hitner , Barbara Nagle 9781259718564 ALL Chapters .
h h h h h h h h
Identifyhthehmainhfunctionhofhmacrophagesh-
hANSWER:hMacrophagesharehscavengerhcellshthathengulfhand hdigesthinfectioushorganismshandhforeignhs
ubstances
IdentifyhthehrolehofhhelperhT-cellhlymphocyteshinhregulatinghthehactivityhofhthehimmunehsystemh-
hANSWER:hThehfunctionhofhhelperhT-
cellshishtohrecognizehthehforeignhantigenshpresentedhtohthemhbyhmacrophageshandhotherhantigen-
presentinghcells
Whichhofhthehfollowinghdiseaseshishanhimmune-
basedhdiseasehthathishtreatedhbyhsuppressinghthehimmunehresponse?h-hANSWER:hMultiplehsclerosis
Myastheniahgravis
Systemichlupusherythematosus
Whichhofhthehfollowinghishthehmainhimmunosuppressiveheffecthofhthehcorticosteroids?h-
hANSWER:hThehcorticosteroidshcausehlymphocyteshinhthehbloodhtohbehredistributedhintohthehbonehmarr
ow
Identifyhthehstatemenththathbesthexplainshhowhazathioprineh(Imuran)hworkshtohtreathlupusherythemato
sush-
hANSWER:hAzathioprineh{prevents}hthehproductionhofhadeninehandhguanine,hwhichhleadshtohthehsuppre
ssionhofhexistinghlymphocyteshandhsuppresseshthehformationhofhnewhB-cellshandhT-cells
Identifyhthehclinicalhindicationshforhthehusehofhmycophenolatehmofetilh(CellCept)h-
hANSWER:hMycophenolatehmofetilhishusedhinhrenalhorganhtransplantationhtohpreventhrejection.
Thehusehofhinfliximabh(Remicade)hleadshtohanhinfusionhreactionhthath-
hANSWER:hcanhincludehfever,hchills,hhives,hhypotension,handhchesthpain
Thehcommonhadverseheffectshofhthehusehofhinterferonshareh-hANSWER:hflu-
likehsymptomshsuchhashchills,hfever,handhmusclehacheshandhpains
Selecththehstatemenththathaccuratelyhdescribeshthehdifferencehbetweenhimmunomodulationhandhimm
unosuppressionh-hANSWER:hAllhofhtheseharehcorrect
Identifyhthehstatemenththathaccuratelyhexplainshthehsymptomshthathahpatienthbeinghadministeredhfilgr
astimh(Neupogen)hshouldhreporthtohthehphysicianh-
hANSWER:hThehpatienthshouldhimmediatelyhreporthtohthehphysicianhanyhfever,hchills,hGIhdisturbances,ha
ndhmusclehandhbonehpain
Identifyhthehtruehstatementhabouthmacrophagesh-hANSWER:hMacrophagesharehclassifiedhashantigen-
presentinghcells
Selecththehfalsehstatementhrelatedhtohthehadverseheffectshofhazathioprinehandhthehotherhcytotoxichdrug
sh-hANSWER:hNonehofhtheseharehfalse
Selecththehstatemenththathishcorrecthabouthtacrolimush(Prograf)handhcyclosporineh(Sandimmune)h-
hANSWER:hTacrolimushandhcyclosporinehinhibiththehT-cellhlymphocytehactivity
Selecththehtruehstatementhabouththehdifferencehbetweenhthehactionshofhinterleukin-
2h(Proleukin)handhthathofhcolonyhstimulatinghfactorsh(CSF)h-hANSWER:hInterleukin-2hstimulateshB-
cellhproductionhofhantibodieshandhkillerhT-
, cellhactivity,hwhereash{CSFshstimulatehthehbonehmarrow}htohincreasehthehproductionhofhmacrophagesha
ndhgranulocytes
Selecththehtruehstatementhabouththehmechanismhofhactionhofhahnaturalhkillerhcellh-
hANSWER:hThehnaturalhkillerhcellhreleaseshperforinshthathformhahholehinhthehenemyhcellhmembrane
Granzymeshfromhthehnaturalhkillerhcellhenterhthehperforinhholehandhdegradehthehenemyhcellhenzymes
Thehenemyhcellhdieshbyhapoptosis,handhthehmacrophagehengulfshandhdigestshthehdyinghcell
Selecththehfalsehstatementhabouththeheffecthofhlymphopeniahonhthehimmunehresponsehfollowinghadmi
nistrationhofhimmunosuppressivehdrugshlikehthehcorticosteroidsh-
hANSWER:hCorticosteroidshincreasehthehamounthofhlymphoidhtissuehandhcellshinhthehlymphhnodeshandh
spleen
Selecththehfalsehstatementhabouthmemoryhcellshandhtheirhrolehinhthehimmunehresponsehprocesshinhtheh
bodyh-
hANSWER:hMemoryhcellsharehlymphocyteshthathinhibiththehactivityhofhthehimmunehsystemhwhenhthehim
munehresponsehishnohlongerhneeded
Memoryhcellshremainhinhthehbodyhforhmanyhyearshandhcanhquicklyhbecomehreactivatedhtohproducehanhi
mmunehresponsehagainsthanhorganismhthathpreviouslyhinfectedhthehbodyh-
hANSWER:hNonehofhtheseharehfalse
Selecththehtruehstatementhrelatedhtohthehalkylatinghdrughcyclosporineh(Sandimmune)h-
hANSWER:hCyclosporinehinhibitshthehproductionhofhinterleukin-2
Selecththehtruehstatementhabouthinfliximabh(Remicade)h-
hANSWER:hInfliximabhishahmonoclonalhantibodyhthathbindshtohandhinhibitshthehactivityhofhtumorhnecrosi
shfactorh(TNF-alpha)
Samuel,hwhohhashbeenhdiagnosedhwithhlupusherythematosus,hishprescribedhahcytotoxichdrug.hHishdocto
rhexplainshthaththehdrughishconvertedhinhthehbodyhtohmercaptopurine,hwhichhexertshahcytotoxicheffect.h
IthinhibitshthehsynthesishofhpurinehnucleotideshthatharehrequiredhforhDNAhsynthesis.hWhichhofhthehfollo
winghdrugshhashSamuelhbeenhprescribed?h-hANSWER:hAzathioprine
Ethanhishscheduledhforhanhorganhtransplant.hHehishadministeredhahdrughtohpreventhorganhrejection.hTh
ehdrughworkshbyhsuppressinghT-
cellhfunction.hWhichhofhthehfollowinghdrugshhashEthanhbeenhadministered?h-hANSWER:hSandimmune
Loganhishdiagnosedhwithhrheumatoidharthritis.hHehishprescribedhahdrughthathishtohbehtakenhorally.hLoga
nhishinformedhbyhhishdoctorhthaththehdrughhashahhalf-
lifehofh15hdays.hHehalsohexplainshthathhehmayhexperiencehdiarrhea.hWhichhofhthehfollowinghdrugshhashL
oganhbeenhprescribed?h-hANSWER:hArava
Gabrielhishdiagnosedhwithhhairyhcellhleukemia.hHehishprescribedhanhimmunomodulatinghagenththathisha
dministeredhthroughhintramuscularhinjections.hWhichhofhthehfollowinghdrugshhashGabrielhbeenhprescri
bed?h-hANSWER:hIntronhA
Fatimahishsufferinghfromhmultiplehsclerosis.hShehishbeinghadministeredhahdrughthroughhsubcutaneoushin
jectionshthreehtimeshahweek.hWhichhofhthehfollowinghdrugshishFatimahbeinghadministered?h-
hANSWER:hAvonex
_____hishanhimmunomodulatinghagenththathishadministeredhthroughhslowhIVhinfusionhtohtreathrenalhcel
lhcancerh-hANSWER:hProleukin
_____hishanhimmunomodulatinghagenththathishusedhtohtreathKaposi'shsarcomah-hANSWER:hRoferon-A
h h h h h h h h h
nry Hitner , Barbara Nagle 9781259718564 ALL Chapters .
h h h h h h h h
Identifyhthehmainhfunctionhofhmacrophagesh-
hANSWER:hMacrophagesharehscavengerhcellshthathengulfhand hdigesthinfectioushorganismshandhforeignhs
ubstances
IdentifyhthehrolehofhhelperhT-cellhlymphocyteshinhregulatinghthehactivityhofhthehimmunehsystemh-
hANSWER:hThehfunctionhofhhelperhT-
cellshishtohrecognizehthehforeignhantigenshpresentedhtohthemhbyhmacrophageshandhotherhantigen-
presentinghcells
Whichhofhthehfollowinghdiseaseshishanhimmune-
basedhdiseasehthathishtreatedhbyhsuppressinghthehimmunehresponse?h-hANSWER:hMultiplehsclerosis
Myastheniahgravis
Systemichlupusherythematosus
Whichhofhthehfollowinghishthehmainhimmunosuppressiveheffecthofhthehcorticosteroids?h-
hANSWER:hThehcorticosteroidshcausehlymphocyteshinhthehbloodhtohbehredistributedhintohthehbonehmarr
ow
Identifyhthehstatemenththathbesthexplainshhowhazathioprineh(Imuran)hworkshtohtreathlupusherythemato
sush-
hANSWER:hAzathioprineh{prevents}hthehproductionhofhadeninehandhguanine,hwhichhleadshtohthehsuppre
ssionhofhexistinghlymphocyteshandhsuppresseshthehformationhofhnewhB-cellshandhT-cells
Identifyhthehclinicalhindicationshforhthehusehofhmycophenolatehmofetilh(CellCept)h-
hANSWER:hMycophenolatehmofetilhishusedhinhrenalhorganhtransplantationhtohpreventhrejection.
Thehusehofhinfliximabh(Remicade)hleadshtohanhinfusionhreactionhthath-
hANSWER:hcanhincludehfever,hchills,hhives,hhypotension,handhchesthpain
Thehcommonhadverseheffectshofhthehusehofhinterferonshareh-hANSWER:hflu-
likehsymptomshsuchhashchills,hfever,handhmusclehacheshandhpains
Selecththehstatemenththathaccuratelyhdescribeshthehdifferencehbetweenhimmunomodulationhandhimm
unosuppressionh-hANSWER:hAllhofhtheseharehcorrect
Identifyhthehstatemenththathaccuratelyhexplainshthehsymptomshthathahpatienthbeinghadministeredhfilgr
astimh(Neupogen)hshouldhreporthtohthehphysicianh-
hANSWER:hThehpatienthshouldhimmediatelyhreporthtohthehphysicianhanyhfever,hchills,hGIhdisturbances,ha
ndhmusclehandhbonehpain
Identifyhthehtruehstatementhabouthmacrophagesh-hANSWER:hMacrophagesharehclassifiedhashantigen-
presentinghcells
Selecththehfalsehstatementhrelatedhtohthehadverseheffectshofhazathioprinehandhthehotherhcytotoxichdrug
sh-hANSWER:hNonehofhtheseharehfalse
Selecththehstatemenththathishcorrecthabouthtacrolimush(Prograf)handhcyclosporineh(Sandimmune)h-
hANSWER:hTacrolimushandhcyclosporinehinhibiththehT-cellhlymphocytehactivity
Selecththehtruehstatementhabouththehdifferencehbetweenhthehactionshofhinterleukin-
2h(Proleukin)handhthathofhcolonyhstimulatinghfactorsh(CSF)h-hANSWER:hInterleukin-2hstimulateshB-
cellhproductionhofhantibodieshandhkillerhT-
, cellhactivity,hwhereash{CSFshstimulatehthehbonehmarrow}htohincreasehthehproductionhofhmacrophagesha
ndhgranulocytes
Selecththehtruehstatementhabouththehmechanismhofhactionhofhahnaturalhkillerhcellh-
hANSWER:hThehnaturalhkillerhcellhreleaseshperforinshthathformhahholehinhthehenemyhcellhmembrane
Granzymeshfromhthehnaturalhkillerhcellhenterhthehperforinhholehandhdegradehthehenemyhcellhenzymes
Thehenemyhcellhdieshbyhapoptosis,handhthehmacrophagehengulfshandhdigestshthehdyinghcell
Selecththehfalsehstatementhabouththeheffecthofhlymphopeniahonhthehimmunehresponsehfollowinghadmi
nistrationhofhimmunosuppressivehdrugshlikehthehcorticosteroidsh-
hANSWER:hCorticosteroidshincreasehthehamounthofhlymphoidhtissuehandhcellshinhthehlymphhnodeshandh
spleen
Selecththehfalsehstatementhabouthmemoryhcellshandhtheirhrolehinhthehimmunehresponsehprocesshinhtheh
bodyh-
hANSWER:hMemoryhcellsharehlymphocyteshthathinhibiththehactivityhofhthehimmunehsystemhwhenhthehim
munehresponsehishnohlongerhneeded
Memoryhcellshremainhinhthehbodyhforhmanyhyearshandhcanhquicklyhbecomehreactivatedhtohproducehanhi
mmunehresponsehagainsthanhorganismhthathpreviouslyhinfectedhthehbodyh-
hANSWER:hNonehofhtheseharehfalse
Selecththehtruehstatementhrelatedhtohthehalkylatinghdrughcyclosporineh(Sandimmune)h-
hANSWER:hCyclosporinehinhibitshthehproductionhofhinterleukin-2
Selecththehtruehstatementhabouthinfliximabh(Remicade)h-
hANSWER:hInfliximabhishahmonoclonalhantibodyhthathbindshtohandhinhibitshthehactivityhofhtumorhnecrosi
shfactorh(TNF-alpha)
Samuel,hwhohhashbeenhdiagnosedhwithhlupusherythematosus,hishprescribedhahcytotoxichdrug.hHishdocto
rhexplainshthaththehdrughishconvertedhinhthehbodyhtohmercaptopurine,hwhichhexertshahcytotoxicheffect.h
IthinhibitshthehsynthesishofhpurinehnucleotideshthatharehrequiredhforhDNAhsynthesis.hWhichhofhthehfollo
winghdrugshhashSamuelhbeenhprescribed?h-hANSWER:hAzathioprine
Ethanhishscheduledhforhanhorganhtransplant.hHehishadministeredhahdrughtohpreventhorganhrejection.hTh
ehdrughworkshbyhsuppressinghT-
cellhfunction.hWhichhofhthehfollowinghdrugshhashEthanhbeenhadministered?h-hANSWER:hSandimmune
Loganhishdiagnosedhwithhrheumatoidharthritis.hHehishprescribedhahdrughthathishtohbehtakenhorally.hLoga
nhishinformedhbyhhishdoctorhthaththehdrughhashahhalf-
lifehofh15hdays.hHehalsohexplainshthathhehmayhexperiencehdiarrhea.hWhichhofhthehfollowinghdrugshhashL
oganhbeenhprescribed?h-hANSWER:hArava
Gabrielhishdiagnosedhwithhhairyhcellhleukemia.hHehishprescribedhanhimmunomodulatinghagenththathisha
dministeredhthroughhintramuscularhinjections.hWhichhofhthehfollowinghdrugshhashGabrielhbeenhprescri
bed?h-hANSWER:hIntronhA
Fatimahishsufferinghfromhmultiplehsclerosis.hShehishbeinghadministeredhahdrughthroughhsubcutaneoushin
jectionshthreehtimeshahweek.hWhichhofhthehfollowinghdrugshishFatimahbeinghadministered?h-
hANSWER:hAvonex
_____hishanhimmunomodulatinghagenththathishadministeredhthroughhslowhIVhinfusionhtohtreathrenalhcel
lhcancerh-hANSWER:hProleukin
_____hishanhimmunomodulatinghagenththathishusedhtohtreathKaposi'shsarcomah-hANSWER:hRoferon-A
