Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
1|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 9th Edition
Table of contents:
I. Principles Of Laboratory Medicine
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
Chapter 2. Selection and Analytical Evaluation of Methods With Statistical Techniques
Chapter 3. Clinical Evaluation of Methods
Chapter 4. Evidence-Based Laboratory Medicine
Chapter 5. Establishment and Use of Reference Values
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
Chapter 7. Quality Management
II. Analytical Techniques And Instrumentation
Chapter 8. Principles of Basic Techniques and Laboratory Safety
Chapter 9. Optical Techniques
Chapter 10. Electrochemistry and Chemical Sensors
Chapter 11. Electrophoresis
Chapter 12. Chromatography
Chapter 13. Mass Spectrometry
Chapter 14. Enzyme and Rate Analyses
Chapter 15. Immunochemical Techniques
Chapter 16 Automation
Chapter 17. Point-of-Care Instrumentation
III. Analytes
Chapter 18. Amino Acids, Peptides, and Proteins
Chapter 19. Serum Enzymes
Chapter 20. Tumor Markers and Cancer Genes
Chapter 21. Kidney Function Tests Creatinine, GFR, Urea, and Uric Acid
Chapter 22. Carbohydrates
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
Chapter 24. Electrolytes and Blood Gases
Chapter 25. Hormones
Chapter 26. Catecholamines and Serotonin
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
Chapter 28. Hemoglobin, Iron, and Bilirubin
Chapter 29. Porphyrins and Porphyrias
Chapter 30. Therapeutic Drugs and Their Management
Chapter 31. Clinical Toxicology
Chapter 32. Toxic Metals
IV. Pathophysiology
Chapter 33. Diabetes
2|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
Chapter 34. Cardiovascular Disease
Chapter 35. Kidney Disease
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
Chapter 37. Liver Disease
Chapter 38. Gastrointestinal and Pancreatic Diseases
Chapter 39. Disorders of Bone and Mineral Metabolism
Chapter 40. Disorders of the Pituitary Gland
Chapter 41. Disorders of the Adrenal Cortex
Chapter 42. Thyroid Disorders
Chapter 43. Reproduction-Related Disorders
Chapter 44. Pregnancy and Prenatal Testing
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
Chapter 46. Pharmacogenetics
V. Molecular Diagnostics
Chapter 47. Principles of Molecular Biology
Chapter 48. Nucleic Acid Techniques and Applications
Chapter 49. Genomes and Nucleic Acid Alterations
3|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition
(Saunders, 2023) by Nader Rifai, Isbn no; 9780323935838, all 49 Chapters Covered
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative who works for a company that sells
chemistry laboratory supplies. When the laboratory manager requests a list of needed supplies, cost of supplies, and vendors, this
individual
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field and commercial suppliers of drugs,
devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturers and providers of diagnostic equipment
and supplies. These concerns led the National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the pain following her recent surgery. A
friend of the patient claims that the same
states that the difference in the effect of the drug might be caused by , which is studied in pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the name of a close friend printed on the bar-
coded label. The genetic test that is ordered on
a poor prognosis, and the test is usually performed by John. He asks a fellow employee to analyze the sample for him and not
divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
4|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
ANS: A
Clinical laboratorians have long been responsible for maintaining the confidentiality of all laboratory results, a situation made
even more critical with the advent of increasingly powerful genetic testing.
DIF: 1 REF: Page 4 OBJ: 6 | 7
4. Molecular diagnostic testing methods and results can be:
a. qualitative only.
b. quantitative only.
c. either qualitative or quantitative.
ANS: C
Molecular diagnostic methods can be either qualitative or quantitative in nature, depending on the clinical need.
DIF: 1 REF: Page 3 OBJ: 5
5. Clinical epidemiology, which is the study of the patterns, causes, and effects of health and disease in certain populations, has provided
the clinical laboratory with methods that evaluate the effects and outcomes of laboratory testing. This allows for a more effective:
a. process of determining the cost of the testing methods.
b. selection and interpretation of laboratory tests.
c. determination of the boundaries between the components of the clinical lab.
d. conduct assessment.
ANS: A
Clinical epidemiologists have introduced methods to evaluate the effects and value of laboratory testing in healthcare. These
developments are expected to play an increasing role in the selection and interpretation of laboratory tests.
DIF: 1 REF: Page 3 OBJ: 4
6. Analysis of which one of the following by molecular diagnostic methods provides a measure of processes that are ongoing at the time
of blood sampling?
a. Genetic variation in an response to a drug
b. Circulating plasma nucleic acids
c. Malignant lymphomas
d. Histocompatibility
ANS: B
Molecular diagnostics, given its very high sensitivity, has been applied to the study of plasma nucleic acids (or circulating nucleic
acids). Plasma nucleic acids analysis has been made possible by the discovery that dying cells in the body release their DNA and RNA
into the extracellular compartment and ultimately into the bloodstream, where they can be detected and analyzed. Given their short
half-life in circulation (less than 24 hours), plasma nucleic acids provide a measure of processes that are ongoing at the time of blood
sampling.
DIF: 1 REF: Page 3 OBJ: 5
5|P a g e
1|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 9th Edition
Table of contents:
I. Principles Of Laboratory Medicine
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
Chapter 2. Selection and Analytical Evaluation of Methods With Statistical Techniques
Chapter 3. Clinical Evaluation of Methods
Chapter 4. Evidence-Based Laboratory Medicine
Chapter 5. Establishment and Use of Reference Values
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
Chapter 7. Quality Management
II. Analytical Techniques And Instrumentation
Chapter 8. Principles of Basic Techniques and Laboratory Safety
Chapter 9. Optical Techniques
Chapter 10. Electrochemistry and Chemical Sensors
Chapter 11. Electrophoresis
Chapter 12. Chromatography
Chapter 13. Mass Spectrometry
Chapter 14. Enzyme and Rate Analyses
Chapter 15. Immunochemical Techniques
Chapter 16 Automation
Chapter 17. Point-of-Care Instrumentation
III. Analytes
Chapter 18. Amino Acids, Peptides, and Proteins
Chapter 19. Serum Enzymes
Chapter 20. Tumor Markers and Cancer Genes
Chapter 21. Kidney Function Tests Creatinine, GFR, Urea, and Uric Acid
Chapter 22. Carbohydrates
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
Chapter 24. Electrolytes and Blood Gases
Chapter 25. Hormones
Chapter 26. Catecholamines and Serotonin
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
Chapter 28. Hemoglobin, Iron, and Bilirubin
Chapter 29. Porphyrins and Porphyrias
Chapter 30. Therapeutic Drugs and Their Management
Chapter 31. Clinical Toxicology
Chapter 32. Toxic Metals
IV. Pathophysiology
Chapter 33. Diabetes
2|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
Chapter 34. Cardiovascular Disease
Chapter 35. Kidney Disease
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
Chapter 37. Liver Disease
Chapter 38. Gastrointestinal and Pancreatic Diseases
Chapter 39. Disorders of Bone and Mineral Metabolism
Chapter 40. Disorders of the Pituitary Gland
Chapter 41. Disorders of the Adrenal Cortex
Chapter 42. Thyroid Disorders
Chapter 43. Reproduction-Related Disorders
Chapter 44. Pregnancy and Prenatal Testing
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
Chapter 46. Pharmacogenetics
V. Molecular Diagnostics
Chapter 47. Principles of Molecular Biology
Chapter 48. Nucleic Acid Techniques and Applications
Chapter 49. Genomes and Nucleic Acid Alterations
3|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition
(Saunders, 2023) by Nader Rifai, Isbn no; 9780323935838, all 49 Chapters Covered
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative who works for a company that sells
chemistry laboratory supplies. When the laboratory manager requests a list of needed supplies, cost of supplies, and vendors, this
individual
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field and commercial suppliers of drugs,
devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturers and providers of diagnostic equipment
and supplies. These concerns led the National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the pain following her recent surgery. A
friend of the patient claims that the same
states that the difference in the effect of the drug might be caused by , which is studied in pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the name of a close friend printed on the bar-
coded label. The genetic test that is ordered on
a poor prognosis, and the test is usually performed by John. He asks a fellow employee to analyze the sample for him and not
divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
4|P a g e
, Test Bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition (Saunders, 2023) by Nader Rifai, all 49 Chapters Covered
ANS: A
Clinical laboratorians have long been responsible for maintaining the confidentiality of all laboratory results, a situation made
even more critical with the advent of increasingly powerful genetic testing.
DIF: 1 REF: Page 4 OBJ: 6 | 7
4. Molecular diagnostic testing methods and results can be:
a. qualitative only.
b. quantitative only.
c. either qualitative or quantitative.
ANS: C
Molecular diagnostic methods can be either qualitative or quantitative in nature, depending on the clinical need.
DIF: 1 REF: Page 3 OBJ: 5
5. Clinical epidemiology, which is the study of the patterns, causes, and effects of health and disease in certain populations, has provided
the clinical laboratory with methods that evaluate the effects and outcomes of laboratory testing. This allows for a more effective:
a. process of determining the cost of the testing methods.
b. selection and interpretation of laboratory tests.
c. determination of the boundaries between the components of the clinical lab.
d. conduct assessment.
ANS: A
Clinical epidemiologists have introduced methods to evaluate the effects and value of laboratory testing in healthcare. These
developments are expected to play an increasing role in the selection and interpretation of laboratory tests.
DIF: 1 REF: Page 3 OBJ: 4
6. Analysis of which one of the following by molecular diagnostic methods provides a measure of processes that are ongoing at the time
of blood sampling?
a. Genetic variation in an response to a drug
b. Circulating plasma nucleic acids
c. Malignant lymphomas
d. Histocompatibility
ANS: B
Molecular diagnostics, given its very high sensitivity, has been applied to the study of plasma nucleic acids (or circulating nucleic
acids). Plasma nucleic acids analysis has been made possible by the discovery that dying cells in the body release their DNA and RNA
into the extracellular compartment and ultimately into the bloodstream, where they can be detected and analyzed. Given their short
half-life in circulation (less than 24 hours), plasma nucleic acids provide a measure of processes that are ongoing at the time of blood
sampling.
DIF: 1 REF: Page 3 OBJ: 5
5|P a g e
