NURS 660 EXAM 2 QUESTIONS WITH 100% CORRECTLY SOLVED ANSWERS.

NURS 660 EXAM 2 QUESTIONS WITH 100% CORRECTLY
SOLVED ANSWERS.



1) What neurotransmitter are affected by TCAs? -- Answer ✔✔ Serotonin, dopamine,
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norepinephrine, 5HT t




2) What TCA medication should absolutely not be used in combination with any other
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MAOI? -- Answer ✔✔ clomipramine
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3) A pt has had some success with his current antidepression medication, has tried many
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different antidepressants, so you decide to augment with L-methyl-folate. What is the
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hypothesis behind L methyl Folate boosting the therapeutic efficacy of
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antidepressants...what is the MOA? -- Answer ✔✔ boosts monoamine t t t t t t t t t




neurotransmitter function in bipolar disorder t t t t




4) A 26 yo female pts with BPAD presents, she was on lithium and ODed, and she now
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presents with tremor, ataxia, confusion and attempted to commit Suicide 30 mins
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before. Lithium lvl is 2.1. Over next 30 mins becomes more confused and
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unresponsive. What is the next step in management -- Answer ✔✔ emergency
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hemodialysis

5) Which antidepressant can cause the most weight gain, would it be: -- Answer ✔✔
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mirtazapine

6) A pt comes to see you and is taking 2 SSRIs (one recently increased) and is c/o
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tremors, diarrhea and agitation. What condition do you expect -- Answer ✔✔
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serotonin syndrome t

, 7) what symptoms that characterize the toxicity of clomipramine... -- Answer ✔✔
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seizures, coma t




8) What is lamotrigine's unique therapeutic profile in BP disorder and depression? --
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Answer ✔✔ linked to inhibition glutamate release
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9) Which medication would you warn clients not to stop abruptly? -- Answer ✔✔
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Effexor

10) You are going to be prescribing a CYP34A inducer...what medication should you
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avoid adding into the pt's med profile? -- Answer ✔✔ CYP3A4 substrate
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11) Medications with the MOA of reuptake of 5HT -- Answer ✔✔ Paxil, Celexa, Zoloft,
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Prozac, fluvoxamine, and Lexapro t t t




12) Medications with the MOA of the reuptake of 5HT and norepinephrine -- Answer
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✔✔ duloxetine, Effexor
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13) What is the MOA of agomelatine? -- Answer ✔✔ Binds to melatonin receptors in the
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suprachiasmatic nucleus and to 5HT2C receptors t t t t t




14) Agents that block the reuptake of norepinephrine, has what effect on the dopamine in
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tthe prefrontal cortex -- Answer ✔✔ increased dopamine in PFC
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15) You have a pt that has been very depressed and has insomnia problems with
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concentrations, weight loss and SI. You start them on an AD and his symptoms have t t t t t t t t t t t t t t t




abated, however which of the following symptoms is the most likely to be residual
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following the successful tx of other symptoms? -- Answer ✔✔ insomnia
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16) Which class of antidepressant have a lower incidence of sexual SE? What medication
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is used in the tx of BP/mania and is used in prophylaxis as well as antidepressant
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augmentation? Which medication is this? -- Answer ✔✔ Wellbutrin t t t t t t t t




17) What medication is a very potent CYP450 inhibitor and can dangerously elevate
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lamotrigine? -- Answer ✔✔ Valproate t t t t