NURS 660 PSYCHOPHARM 2024 / 2025 EXAM QUESTIONS WITH SOLVED ANSWERS (A+ GRADED.)

NURS 660 PSYCHOPHARM 2024/2025 EXAM QUESTIONS
WITH SOLVED ANSWERS || A+ GRADED.




Dopamine deficiency in the nigrostriatal pathway can cause: (4) -- Correct Answer ✔✔ 1.
t t t t t t t t t t t t t t




Parkinsonism w/ tremor t t




2. Rigidity t




3. Akinesia t




4. Bradykinesia
t




Excess dopamine in the nigrostriatal pathway can cause: Hyperkinetic movements (3) --
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Correct Answer ✔✔ Tics t t t




Dyskinesia (involuntary movement) t t




Chorea (dance) t




Chronic blockage of D2 receptors at the Nigrostriatal pathway causes: -- Correct Answer
t t t t t t t t t t t t t




✔✔ Tardive dyskinesia
t t




Role of Mesolimbic pathway in schizophrenia: -- Correct Answer ✔✔ Regulates emotional
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behaviors
t




Mesolimbic pathway is responsible for these feelings:
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2 -- Correct Answer ✔✔ - Pleasure sensation
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- POWERFUL EUPHORIA
t t




Mesolimbic pathway is responsible for these ________ symptoms:
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3 -- Correct Answer ✔✔ Positive symptoms
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1. Delusionst




2. Hallucinations
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3. Hyperactivity
t

,Role of mesocortical pathway in schizophrenia: to send ____ to areas of the _______
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_____ -- Correct Answer ✔✔ Axons to areas of the prefrontal cortex
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Axons sent via the mesocortical pathway mediate _________ symptoms in the DLPFC
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and _______ symptoms in the VMPFC -- Correct Answer ✔✔ cognitive symptoms and
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affective

Dorsolateral prefrontal cortex (DLPFC) mediate __________ symptoms of t t t t t t t t




schizophrenia due to _____ of the mesocortical dopamine pathway. -- Correct Answer
t t t t t t t t t t t t




✔✔ negative symptoms
t t




HYPO activity t




Medical emergencies when prescribing anti-psychotics -- Correct Answer ✔✔ - NMS
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- Agranulocytosis
t




- Serotonin Syndrome
t t




Clinical findings in agranulocytosis -- Correct Answer ✔✔
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Clozaril: most likely side effect if pt develops fever within 6 weeks -- Correct Answer ✔✔
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Myocarditis

Clozaril: if pt develops fever within 6 weeks order a ______, _________ and _______. -
t t t t t t t t t t t t t t




- Correct Answer ✔✔ EKG, CRP, Troponin, as this is likely due to myocarditis
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Negative symptoms (reflect loss of normal function and feeling): -- Correct Answer ✔✔
t t t t t t t t t t t t t




Losing interest in things
t t t




Not able to experience pleasure: adehonia
t t t t t




Blunted affect t




Emotional withdrawal t




Poor rapport t




Apathy
Alogia: restriction in fluency or productivity of thought and speech
t t t t t t t t t




Avolition: restrictions in initiation of goal directed behavior
t t t t t t t

, Malfunction of mesocortical circuits and may also involve mesolimbic regions such as --
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Correct Answer ✔✔ nucleus accumbens
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Nucleus accumbens responsible for: (2) -- Correct Answer ✔✔ reward and motivation.
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Increased rate of substance use and abuse.
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The dopamine hypothesis of schizophrenia postulates that hyperactivity of
t t t t t t t t t




________receptor neurotransmission in ________ and ____ brain regions contribute t t t t t t t t t




to _______ symptoms of schizophrenia -- Correct Answer ✔✔ - D2 receptor
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neurotransmission in t t




-subcortical and limbic brain regions contributes to positive symptoms of schizophrenia,
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The dopamine hypothesis of schizophrenia postulates that negative and cognitive
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symptoms of this disorder can be attributed to ____ of __ receptor in the _____ ____ --
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Correct Answer ✔✔ hypo functionality of dopamine D1 receptor neurotransmission in
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the prefrontal cortex
t t




Common complaints in patients with neutropenia:
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F,P, U, P -- Correct Answer ✔✔ - Fever (low grade)
t t t t t t t t t t




- painful swallowing (odynophagia)
t t t




- URI (sinusitis, otitis, cough)
t t t t




- Perirectal pain/irritation
t t




Symptoms of neuroleptic malignant syndrome (NMS): -- Correct Answer ✔✔ - High fever
t t t t t t t t t t t t




- Tachycardia/irregular pulse
t t




- Increased respiratory rate
t t t




- Muscle Rigidity
t t




- altered mental status
t t t




Off label TX for NMS -- Correct Answer ✔✔ Amantadine (SYMMETREL)
t t t t t t t t t t




Serotonin Syndrome onset: -- Correct Answer ✔✔ -24 hours of combining
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antidepressants

Serotonin Syndrome Cardinal features -- Correct Answer ✔✔ - Myoclonic jerks
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- Hyperreflexia
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