NURS 660 EXAM 4 QUESTIONS WITH FULLY SOLVED & UPDATED ANSWERS

NURS 660 EXAM 4 QUESTIONS WITH FULLY SOLVED &
UPDATED ANSWERS.



1) Which medication is contraindicated with liver impairment? -- Answer ✔✔
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Atomoxine (Strattera) t




2) What is one of the birth defects associated with Lithium? -- Answer ✔✔ Ebstein's
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anomaly

3) Which SSRI drug causes cardiovascular malformations in the first trimester of
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pregnancy? -- Answer ✔✔ Paroxetine (Paxil) t t t t t




4) Mechanism of action of a stimulant for ADHD Methylphenidate and amphetamine? -
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- Answer ✔✔ increases the intrasynaptic levels of both dopamine and
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norepinephrine

5) What causes nicotine withdrawal symptoms? -- Answer ✔✔ Nicotine alpha 4 beta 2
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post synaptic receptors desensitizes receptors which leads to addiction. Re-
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sensitization of the nicotine receptors leads to withdrawal t t t t t t t




6) A patient diagnosed with ADHD can't stay focused or solve work-related problems
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difficulty maintaining attention sustained and problem-solving. What area of the
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brain is involved? -- Answer ✔✔ Dorsal lateral prefrontal cortex (CTSC loop)
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7) What part of the brain is associated with selective attention? -- Answer ✔✔ Dorsal
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anterior singlunate t




8) What part of the brain is associated with hyperactivity? -- Answer ✔✔ Prefrontal
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motor cortex t

, 9) What part of the brain is associated with impulsivity? -- Answer ✔✔ Orbitofrontal
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cortex

10) Atomoxetine (Strattera) lacks abuse potential because of what -- Answer ✔✔ t t t t t t t t t t t




increases dopamine in the dorsal prefrontal cortex and not in the nucleus
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accumbens

11) What fetal malformation does valproate cause? -- Answer ✔✔ Spina bifida
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12) What region of the brain is hypothesized to cause impulsivity? -- Answer ✔✔ ventral
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tstriatum

13) What region of the brain controls compulsivity? -- Answer ✔✔ Dorsal striatum
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14) What is the MOA of atomoxetine (Strattera)? -- Answer ✔✔ Selective
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Norepinephrine Reuptake Inhibitor: Boosts neurotransmitter norepinephrine/ t t t t t t




noradrenaline and may also increase dopamine in prefrontal cortex • Blocks t t t t t t t t t t t




norepinephrine reuptake pumps, also known as norepinephrine transporters • t t t t t t t t




15) Amaloid precursor protein is first cleaved by what enzyme -- Answer ✔✔ Alpha-
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secretase

16) What does paroxetine do to Strattera in the body? -- Answer ✔✔ increases the
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effect of the drug in the body
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17) If a patient is taking paroxetine and starts Strattera what should change about the
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Strattera dose? -- Answer ✔✔ The dose should be decreased
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18) An Alzheimer's patient has been taking 4mg of rivastigmine what side effects might
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you anticipate and why? -- Answer ✔✔ GI side effects; inhibits peripheral uptake of
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ACH and butyrylcholine
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19) Which neurotransmitters lead to euphoria and abuse in a patient with marijuana
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abuse and ADHD. -- Answer ✔✔ Pulsatile delivery of stimulants can cause a
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