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Exam (elaborations)

PH QUESTIONS WITH DETAILED VERIFIED ANSWERS (100% CORRECT ANSWERS) /ALREADY GRADED A+

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Quiz: 3 R's of animal research Ans: Replacement- replace animal with human cells, most don't agree w this Reduction- keep number of animals as small as possible Refinement- fine tune experiments to limit waste and stress on animals Quiz: Zebrafish Model Ans: George Stridinger- University of oregon Christiane Nusslein Volhard- Germany both used zebrafish model in research. zebrafish anatomy very similar to humans, are transparent so easy to study molecular biology and more Quiz: How do u use punnet square Ans: box lol Quiz: Victor Hamburger Ans: founder of modern vertebrate neuroembryology "embryo is our teacher". found the start things in chick's and zebradish "spontaneous Examstudy - Stuvia US locomotion" like baby kick in pregnancy. also discovered cell death in normal development, this is called programmed cell death, PCD Quiz: How many cells in C. elegans (hermaphrodite vs males) Ans: 959 hermaphrodite, 1031 cells male Quiz: C. elegans cell death Ans: 131 cells die, basically the same as human cell death. C. elegans good model to study cell death (Sydney brenner- advocate for this model) Quiz: Green florescent protein GFP Ans: from jellyfish, Martin Chelfie won Nobel prize, watch cells develop transgenic worm- worm that has been engineered to have GFP in body from jellyfish Quiz: Cell death pathways worm Ans: inhibit CED9, cell dies activate CED9, cell lives activate CED3 and 4, cell death Quiz: Cell death pathways mammal Ans: inhibit bcl2- apaf1-caspace9-> get apoptosis Quiz: Apoptos

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Institution
PH340
Course
PH340

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Uploaded on
January 20, 2025
Number of pages
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Written in
2024/2025
Type
Exam (elaborations)
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PH 3462025- 2026 QUESTIONS WITH DETAILED
VERIFIED ANSWERS (100% CORRECT ANSWERS)
/ALREADY GRADED A+
Quiz: 3 R's of animal research

Ans: Replacement- replace animal with human cells, most don't agree w
this


Reduction- keep number of animals as small as possible


Refinement- fine tune experiments to limit waste and stress on animals



Quiz: Zebrafish Model

Ans: George Stridinger- University of oregon


Christiane Nusslein Volhard- Germany


both used zebrafish model in research. zebrafish anatomy very similar to
humans, are transparent so easy to study molecular biology and more



Quiz: How do u use punnet square

Ans: box lol



Quiz: Victor Hamburger

Ans: founder of modern vertebrate neuroembryology "embryo is our
teacher". found the start things in chick's and zebradish "spontaneous

, locomotion" like baby kick in pregnancy. also discovered cell death in
normal development, this is called programmed cell death, PCD



Quiz: How many cells in C. elegans (hermaphrodite vs males)

Ans: 959 hermaphrodite, 1031 cells male



Quiz: C. elegans cell death

Ans: 131 cells die, basically the same as human cell death. C. elegans
good model to study cell death (Sydney brenner- advocate for this
model)



Quiz: Green florescent protein GFP

Ans: from jellyfish, Martin Chelfie won Nobel prize, watch cells develop


transgenic worm- worm that has been engineered to have GFP in body from
jellyfish



Quiz: Cell death pathways worm

Ans: inhibit CED9, cell dies
activate CED9, cell lives
activate CED3 and 4, cell death



Quiz: Cell death pathways mammal

Ans: inhibit bcl2- apaf1-caspace9-> get apoptosis



Quiz: Apoptosis

Examstudy - Stuvia US

, Ans: cell death



Quiz: BMP4

Ans: causes cell death



Quiz: Gremlin

Ans: inhibits BMPs. if gremlin up, BMP down; digits in hand do not develop
correctly (webbed)



Quiz: Toxins vs toxicants

Ans: naturally occuring-toxins
synthetic bad chemicals-toxicants



Quiz: toxicology is studied from?

Ans: population to cells



Quiz: who said "dose makes the poison"

Ans: parcelus- the father of toxicology



Quiz: dose-reponse

Ans: quantifies exposure and effects



Quiz: What are exposure routes in adults?

Ans: dermal, oral, cut skin, eyes, inhalation


Examstudy - Stuvia US

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