NURS 5334 PHARM Final Exam

"The whole is greater than the sum of its parts" adequately summarizes which of the following drug interactions? a. additivity b. antagonism c. potentiation d. synergism - d. synergism A 36 year old man is brought to the emergency department after being involved in a one car motor vehicle accident where the car struck a telephone pole. He is a known chronic alcoholic, he has alcohol on his breath and his blood alcohol level is 300 mg/dl. Which of the following treatments should be given to him if he goes into alcohol withdrawal. a. buspirone b. lorazepam c. pentobarbital d. phenytoin e. watchful waiting with saline intravenous infusion - b. lorazepam ? A drug that has an effect, but no matter how high of a dose, cannot produce a full agonist effect is called: a. an agonist b. partial agonist c. antagonist d. an inverse agonist - b. partial agonist A fellow dental hygienist acutely present with mottled sweaty skin, total body rigidity and hyporeflexia. Based upon your knowledge of inhalation anesthetics, you determine your friend has been exposed to too much isoflurane and is suffering from malignant hyperthermia. Which of the following drugs would be best to administer to deal with the current situation. a. dantrolene b. naloxone c. morphine d. phenytoin e. diphenhydramine - a. dantrolene A patient begins to have a tonic clonic seizure in your clinic. You call EMS and they arrived very quickly and administer an injection of a drug to halt the seizure. The drug most likely administered is: a. haloperidol b. fluoxetine c. diazepam d. clozapine e. gabapentin - diazepam or lorazepam ? A patient begins to have a tonic clonic seizure in your clinic. You call EMS and they arrived very quickly and administer an injection of a drug to halt the seizure. The drug most likely administered is: - Aspirin is used as an antiplatelet drug by inhibiting: - Atypical antipsychotic medications like clozapine block receptors for which neurotransmitter in addition to dopamine receptors: - Bisoprolol produces its effect by inhibiting which adrenoreceptor? - Drug A has a safety index of 10. Drug B has a safety index of 0.1. Which drug is safe? - Drug A is a 1) a neurotransmitter, 2) an agonist at B1, B2, A1, and A2 receptors, 3) is used to treat severe allergic reactions, and 4) is used by dentist in conjunction with local anesthetics such as lidocaine in order to decrease absorption and increase duration of pain control. Drug X is most likely?? - Factors that can affect drug distribution include: A. Binding to plasma protein B. Regional blood flow C. Blood-brain barrier D. All of the above - Letrozole is used as a second- line treatment for breast cancer in patients whom tamoxifen therapy is unsuccessful. It does this by which MOA? - Midazolam is a benzodiazepine with a relatively short half life of around 30-60 minutes, and that is why it makes an excellent: - Only the ___ form of a drug is available for distribution to sites of action and for ____. - Primary hemostasis includes: A.Constriction of vessel wall B. Platelet aggregation C. Platelet granule release D. All of the above - The ideal general anesthesia should result in the induction of ___ as rapidly as possible - To treat addison with alternative day therapy, which intermediate acting glucocorticoid is the best choice? A. Cortisone B. Hydrocortisone C. Prednisone D. Betamethasone - What is the chelation therapy used to treat copper poisoning? A. EDTA B. Deferoxamine C. Dimercaprol D. Penicillamine - What is the mechanism of action of glucocorticoids on the cellular level? A. The hormone diffusing through the membrane and binding to its nuclear receptor in the cytosol and then traveling to the nucleus where it bind to DNA and it either activates or inhibits gene transcription B. Hormone binding to GPCR located in plasma membrane and traveling to nucleus where bind to DNA and activates or inhibits gene transcription C. The hormone diffusing through membrane and binding to its G protein coupled receptor (GCPR) - What is the MOA of ibuprofen? - What is the MOA of the HIV drug raltegravir? -