Cancer Pharmacology| EXAM QUESTIONS WITH COMPLETE SOLUTIONS (ANSWERS VERIFIED 100% CORRECT)

Cancer Pharmacology| EXAM QUESTIONS WITH
COMPLETE SOLUTIONS (ANSWERS VERIFIED 100%
CORRECT)

Cytarabine MOA - ✔✔Stalls DNA synthesis and blocks DNA/RNA polymerases



Vinca alkaloids MOA - ✔✔Inhibit tubulin/prevent spindle formation



Taxoids MOA - ✔✔Stabilize microtubules (no progression to anaphase)



Alkylating agent example - ✔✔Cyclophosphamide



Alkylating agents MOA - ✔✔Cross-links DNA



Alkylating agents negative effects (3) - ✔✔Mutagenic, teratogenic, carcinogenic



Platinum compounds examples (2) - ✔✔Cisplatin
Carboplatin



Platinum compounds MOA - ✔✔Cross-linking DNA, blocking replication and
transcription


Antitumor abx examples (1) - ✔✔Doxorubicin

, Antitumor abx MOA (3) - ✔✔Intercalate DNA, inhibit transcription and induce
breakage



Doxorubicin negative effects - ✔✔Cardiotoxicity



Topo I inhibitors (2) - ✔✔Topotecan
Irinotecan


Topo II inhibitors MOA - ✔✔DNA ds breaks



Topo I inhibitors MOA - ✔✔DNA ss breaks



Estrogen receptor antagonist - ✔✔Tamoxifen



Androgen receptor inhibitor - ✔✔Enzalutamide



Tamoxifen use - ✔✔Post-menopausal breast cancer



Enzalutamide use - ✔✔Prostate carcinoma



What do aromatase inhibitors target - ✔✔Estrogen pathway



Aromatase inhibitor (1) - ✔✔Letrozole



Letrozole MOA - ✔✔Blocks estrogen production