Biochemistry 301 UW Madison: Exam 2bb
Questions with 100% Correct Answers| Verified-
four major classes of lipoproteins - ✔✔chylomicrons, VLDL, LDL, HDL
the higher the lipid content... - ✔✔the lower the density
the higher the protein content... - ✔✔the higher the density
chylomicrons - ✔✔transport dietary fat from the intestine to peripheral tissues
VLDLs - ✔✔comparable role for triacylglycerols synthesized in the liver
LDLs - ✔✔play a major role in transporting cholesterol to tissues
HDLs - ✔✔play a major role in returning excess cholesterol from tissues to the liver
for metabolism or excretion
Components of lipoproteins - ✔✔triacylglycerols, protein, phospholipids, free
cholesterol, and cholesterol bound to fatty acids
synthesis of fatty acids is in the - ✔✔cytoplasm
breakdown of fatty acids is in the - ✔✔mitochondra
, fatty acid oxidation pathway - ✔✔- activation of the carboxyl group on the fatty acid
(via ATP)
- transport into the mitochondrial matrix
- stepwise oxidation, 2 carbons at a time
fatty acids in the cytosol arise from - ✔✔1. de novo biosynthesis
2. hydrolysis of triacylglycerols
3. transport of fatty acids from fat storage cells
oxidation pathway: steps of activation and transport - ✔✔* starting with a free fatty
acid *
1. activation via adenylation
2. transfer to carnitine
3. transport through the mitochondrial membrane
4. reconjugation with CoA
oxidation pathway: steps of beta oxidation - ✔✔* fatty acid is now in the
mitochondrial matrix *
1. dehydrogenation
2. hydration
3. dehydrogenation
4. thiolytic cleavage, yielding acetyl-CoA plus a fatty acyl-CoA two carbons shorter than
the original
CPT 1 - ✔✔Attaches carnitine to FA-CoA to generate Fatty Acyl Carnitine
Note: CoA removed
Questions with 100% Correct Answers| Verified-
four major classes of lipoproteins - ✔✔chylomicrons, VLDL, LDL, HDL
the higher the lipid content... - ✔✔the lower the density
the higher the protein content... - ✔✔the higher the density
chylomicrons - ✔✔transport dietary fat from the intestine to peripheral tissues
VLDLs - ✔✔comparable role for triacylglycerols synthesized in the liver
LDLs - ✔✔play a major role in transporting cholesterol to tissues
HDLs - ✔✔play a major role in returning excess cholesterol from tissues to the liver
for metabolism or excretion
Components of lipoproteins - ✔✔triacylglycerols, protein, phospholipids, free
cholesterol, and cholesterol bound to fatty acids
synthesis of fatty acids is in the - ✔✔cytoplasm
breakdown of fatty acids is in the - ✔✔mitochondra
, fatty acid oxidation pathway - ✔✔- activation of the carboxyl group on the fatty acid
(via ATP)
- transport into the mitochondrial matrix
- stepwise oxidation, 2 carbons at a time
fatty acids in the cytosol arise from - ✔✔1. de novo biosynthesis
2. hydrolysis of triacylglycerols
3. transport of fatty acids from fat storage cells
oxidation pathway: steps of activation and transport - ✔✔* starting with a free fatty
acid *
1. activation via adenylation
2. transfer to carnitine
3. transport through the mitochondrial membrane
4. reconjugation with CoA
oxidation pathway: steps of beta oxidation - ✔✔* fatty acid is now in the
mitochondrial matrix *
1. dehydrogenation
2. hydration
3. dehydrogenation
4. thiolytic cleavage, yielding acetyl-CoA plus a fatty acyl-CoA two carbons shorter than
the original
CPT 1 - ✔✔Attaches carnitine to FA-CoA to generate Fatty Acyl Carnitine
Note: CoA removed
