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1. Fanconi's anemia is an inherited aplastic anemia with mutations that lead
to:
a. RBC enzymatic defects
b. Increased chromosome fragility
c. Myelophthisic anemia
d. Pancreatic issues: b. Increased chromosome fragility
2. What is the principle of automated impedance cell counters?
a. Amplification of an electrical current by cells
b. Interruption of an electrical current by cells
c. Angle of laser beam scatter by cells
d. Change in optical density of the solution containing cells: b. Interruption of
an electrical current by cells
3. Which of the following statements about manual reticulocyte counts is
false?
a. New methylene blue, a supravital stain, is used.
b. RBC inclusions can result in falsely elevated counts.
c. The blood/stain mixture is incubated for 5-10 minutes.
d. An erythrocyte must have at least 4 blue particles to be counted as a
reticulocyte.: d. An erythrocyte must have at least 4 blue particles to be counted
as a reticulocyte.
4. Which of the following is not an agonist of platelet aggregation?
a. Saline
b. Epinephrine
c. Collagen
d. ADP: a. Saline
5. A clotted EDTA tube can be used to perform a(n)
a. Hematocrit
b. Platelet count
c. Solubility test for hemoglobin S
d. Erythrocyte sedimentation rate: c. Solubility test for hemoglobin S
6. In which of the following are eosinophils not increased?
a. Parasitic infection
b. Gushing syndrome
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c. Allergic disorders
d. Skin disorders: b. Gushing syndrome
7. In which anomaly is a failure of granulocytes to divide beyond the band or
two lobed stage observed?
a. Chediak-Higashi
b. Pelger-Huet
c. Alder-Reilly
d. May-Hegglin: b. Pelger-Huet
8. When performing a factor assay for factor VIII, the MLS accidentally added
factor IX-deficient plasma to the patient specimens. Which of the following
best describes the expected results?
a. The test will not be affected because the correct factor-deficient plasma was
added
b. The test results will be an assessment of factor IX levels and can be
calculated using the factor VIII standard curve
c. The test results will not be an assessment of factor VIII levels because factor
VIII is present in the factor IX-deficient plasma
d. The test will not be affected because factor-deficient plasma is not needed
in a factor assay: c. The test results will not be an assessment of factor VIII levels
because factor VIII is present in the factor IX-deficient plasma
9. A patient's bone marrow showed erythroid hyperplasia with signs of dys-
plastic maturation, particularly in the RBC precursors. This is consistent with
which of the following?
a. Pernicious anemia
b. Sickle cell anemia
c. b-Thalassemia major
d. G6PD deficiency: a. Pernicious anemia
10. What combination of reagents is used to measure hemoglobin?
a. Hydrochloric acid and p-dimethylaminobenzaldehyde
b. Sodium bisulfite and sodium metabisulfite
c. Potassium ferricyanide and potassium cyanide
d. Sodium citrate and hydrogen peroxide: c. Potassium ferricyanide and potassi-
um cyanide
11. The CBC for a 57-year-old man had the following results. Which tests would
be best to order next? RBC 2.50X1012/L; Hct 26.0%; MCH 34 pg; Hgb 8.5 g/dL
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MCV 104 fL MCHC 33%.
a. Vitamin B12 and folic acid levels
b. Iron studies
c. Intrinsic factor antibodies
d. Bone marrow examination: a. Vitamin B12 and folic acid levels
12. Myeloid metaplasia refers to:
a. Extramedullary hematopoiesis
b. Displacement of normal marrow cells by fibrous tissue
c. Hematopoietic failure
d. Tumors (neoplasms) of the bone marrow: a. Extramedullary hematopoiesis
13. A young boy is taken to his pediatrician because his parents noticed that
he seems to bleed easily and has swollen knees. The following test results
were obtained: PT: Normal; APTT: Prolonged; Fibrinogen: Normal; Platelet
count: Normal; aPTT with normal pooled Plasma: Corrected the aPTT. Which
of the following statements best describes the next steps?
a. The pediatrician should request a molecular test for the factor V Leiden
defect
b. The pediatrician should order factor assays for factors X and V
c. The pediatrician should order factor assays for factors VIII and IX
d. The pediatrician should order platelet aggregation testing: c. The pediatrician
should order factor assays for factors VIII and IX
14. To evaluate normal platelet numbers in an appropriate area of a blood
smear,
approximately how many platelets should be observed per oil immersion
field?
a. 20-50
b. 4-10
c. 8-20
d. 1-4: c. 8-20
15. The lack of a secondary wave of platelet aggregation in response to ADP
is associated with which of the following disorders?
a. Glanzmann's thrombasthenia
b. D-Storage pool disease