Sickle cell anemia is a severe hemolytic anemia that results from inheritance,
autosomal recessive, of the sickle hemoglobin gene, hemoglobin (HbS).
Characteristics:
• Sickle shaped; sticky
• sensitive to low O2
• lifespan: 20days
, ETIOLOGY:
• Presence of HbSS indicates active disease while HbAS indicates sickle cell tra
• Black population.
• lesser extent in people from the Middle East, the Mediterranean area, and ab
tribes in India.
PATHOPHYSIOLOGY: NORMAL hemoglobin
HbA
ABNORMAL hemoglob
HbS
AUTOSOMAL RECES