Clotting Cascade Dr. Gardner solved questions
Hemostasis Correct Answer-The normal process of cessation of bleeding
following damage to a blood vessel.
Thrombosis Correct Answer-The formation of a blood clot in part of the
circulatory system (a pathological process).
Thrombosis Correct Answer-This can block blood flow, resulting in
stroke, acute MI, or other complications.
1) blood coagulation (2 parts)
a. platelet plug formation
b. fibrin clot production
2) fibrinolysis-clot breakdown
3) repair of vessel damage Correct Answer-3 phases of hemostasis:
Endothelial cells
Subendothelium
Platelets
Clotting Factors Correct Answer-Factors involved in clotting:
Blood and Subendothelium Correct Answer-Endothelial cells lining
blood vessels act as a barrier between what?
, Limits platelet adhesion and clot formation. Correct Answer-What does
the barrier formed by the endothelial cells of the blood vessels do?
Subendothelium and the ECM Correct Answer-Damage to the
endothelium will expose what two structures?
Clots Correct Answer-ECM binds and activates platelets which can
trigger the formation of what?
ECM collagen Correct Answer-Damage to the endothelium exposes:
They bind and become active. Correct Answer-Upon exposure to ECM
collagen, what happens with platelets?
Platelet plug Correct Answer-As more and more platelets bind to
exposed ECM collagen, what begins to form?
A fibrin clot. Correct Answer-What type of clot forms around the
platelets and trapped RBC's to hold them in place?
Platelets Correct Answer-Small anuclear cellular fragments which are
derived from megakaryocytes:
1K-5K Correct Answer-One megakaryocyte can yield how many
platelets?
Hemostasis Correct Answer-The normal process of cessation of bleeding
following damage to a blood vessel.
Thrombosis Correct Answer-The formation of a blood clot in part of the
circulatory system (a pathological process).
Thrombosis Correct Answer-This can block blood flow, resulting in
stroke, acute MI, or other complications.
1) blood coagulation (2 parts)
a. platelet plug formation
b. fibrin clot production
2) fibrinolysis-clot breakdown
3) repair of vessel damage Correct Answer-3 phases of hemostasis:
Endothelial cells
Subendothelium
Platelets
Clotting Factors Correct Answer-Factors involved in clotting:
Blood and Subendothelium Correct Answer-Endothelial cells lining
blood vessels act as a barrier between what?
, Limits platelet adhesion and clot formation. Correct Answer-What does
the barrier formed by the endothelial cells of the blood vessels do?
Subendothelium and the ECM Correct Answer-Damage to the
endothelium will expose what two structures?
Clots Correct Answer-ECM binds and activates platelets which can
trigger the formation of what?
ECM collagen Correct Answer-Damage to the endothelium exposes:
They bind and become active. Correct Answer-Upon exposure to ECM
collagen, what happens with platelets?
Platelet plug Correct Answer-As more and more platelets bind to
exposed ECM collagen, what begins to form?
A fibrin clot. Correct Answer-What type of clot forms around the
platelets and trapped RBC's to hold them in place?
Platelets Correct Answer-Small anuclear cellular fragments which are
derived from megakaryocytes:
1K-5K Correct Answer-One megakaryocyte can yield how many
platelets?
