Coagulation Cascade questions with correct answer1.

Coagulation Cascade questions with correct answers

Provide a summary diagram of the coagulation cascade. Correct Answer-


What are the main steps of intrinsic pathway activation? Correct Answer-
Damage exposes basement collagen --> Exposed collagen causes
activation of factor XII --> Exposed collagen binds von Willebrand
factor


What initiates the intrinsic coagulation pathway? Correct Answer-Factor
XIIa


What is the role of von Willebrand factor (vWf)? Correct Answer-
Stabilizes platelet binding to collagen via a platelet membrane receptor


In the intrinsic pathway sequence, factor XIIa converts factor XI to
factor ______. Correct Answer-Xia


Factor XIa converts factor IX to factor _____. Correct Answer-IXa


Factor IXa converts factor VIII to factor ____. Correct Answer-VIIIa


Factor VIIIa activates the common pathway by converting factor X to
factor ____. Correct Answer-Xa

, What are the main steps of the extrinsic pathway? Correct Answer-
Damaged tissue cells secrete Tumor Necrosis Factor (TNF) --> TNF
causes endothelial cells, vascular smooth muscle cells, and fibroblasts to
externalize adhesion receptors --> TF converts factor VII to factor VIIa
--> factor VIIa converts factor X to factor Xa


What are the main steps of the common pathway? Correct Answer-Factor
Xa converts prothrombin to thrombin --> thrombin converts factor V to
factor Va, which assists in converting prothrombin to thrombin -->
Thrombin converts fibrinogen to fibrin --> thrombin converts factor XIII
to factor XIIIa


Fibrin crosslinks _______. Correct Answer-platelets


Factor XIIIa stabilizes _______. Correct Answer-crosslinks


What is hemophilia? Correct Answer-Rare deficiencies in intrinsic
pathway factors


Which hemophilia is a deficiency in Factor VIII? Correct Answer-
Hemophilia A


Which hemophilia is a deficiency in Factor IX? Correct Answer-
Hemophilia B


Which hemophilia are X-linked, recessive? Correct Answer-A and B