Bioinformatics Quiz 1
questions and answers
What is Bioinformatics? - answer Bioinformatics is
an interdisciplinary science to compile,
store, and analyze/mine biological and medical
data to help solve problems to improve human
health and well‐being
Differences between bioinformatics and
computational biology - answer Bioinformatics
focuses on storage and analysis
of biological and medical data. Computational
Biology is focused on modeling of biological
processes
Information used to propose the double helix DNA
structure model by Watson and Crick in 1953 -
answer Rosalind Franklin's X-ray data.
Electronegativity? ??? Chargaff's Rule?
What is the central dogma of molecular biology?
Esp. its most important highlight - answer DNA to
RNA to Proteins. (With back and forth). Highlight is
that once info has gotten into a protein, it can't get
back out again.
, Structural integrity of DNA double-helix; why DNA
basepairs are not possible between purines only or
between pyrimidines only? - answer Bonds need to
be a certain length. Purine:purine is too close,
Pyrimidine:pyrimidine is too far.
The numbering system of DNA/RNA nucleotides
(you learned this in lab) - answer Pyrimidines start
at 1 at Nitrogen connected to sugar. Counter-
clockwise to double-bonded oxygen. Purines start
at top-right nitrogen, going clockwise on first ring.
Left ring continues with 7 at top, going counter-
clockwise, finishing with bonding to sugar at 9.
How does DNA replication and duplication differ? -
answer DNA Replication: the semi‐conservative
copying process of entire DNA from its original
DNA before cell division
DNA Duplication: a process to duplicate a
chromosomal region
IUPAC‐IUB symbols for nucleotides; study the
detailed correspondences - answer Examples: 1:1 A
Adenosine (G Guanine etc)
1:2 R means A or G (Purine)
Y means C or T (Pyrimidine)
questions and answers
What is Bioinformatics? - answer Bioinformatics is
an interdisciplinary science to compile,
store, and analyze/mine biological and medical
data to help solve problems to improve human
health and well‐being
Differences between bioinformatics and
computational biology - answer Bioinformatics
focuses on storage and analysis
of biological and medical data. Computational
Biology is focused on modeling of biological
processes
Information used to propose the double helix DNA
structure model by Watson and Crick in 1953 -
answer Rosalind Franklin's X-ray data.
Electronegativity? ??? Chargaff's Rule?
What is the central dogma of molecular biology?
Esp. its most important highlight - answer DNA to
RNA to Proteins. (With back and forth). Highlight is
that once info has gotten into a protein, it can't get
back out again.
, Structural integrity of DNA double-helix; why DNA
basepairs are not possible between purines only or
between pyrimidines only? - answer Bonds need to
be a certain length. Purine:purine is too close,
Pyrimidine:pyrimidine is too far.
The numbering system of DNA/RNA nucleotides
(you learned this in lab) - answer Pyrimidines start
at 1 at Nitrogen connected to sugar. Counter-
clockwise to double-bonded oxygen. Purines start
at top-right nitrogen, going clockwise on first ring.
Left ring continues with 7 at top, going counter-
clockwise, finishing with bonding to sugar at 9.
How does DNA replication and duplication differ? -
answer DNA Replication: the semi‐conservative
copying process of entire DNA from its original
DNA before cell division
DNA Duplication: a process to duplicate a
chromosomal region
IUPAC‐IUB symbols for nucleotides; study the
detailed correspondences - answer Examples: 1:1 A
Adenosine (G Guanine etc)
1:2 R means A or G (Purine)
Y means C or T (Pyrimidine)
