Ch. 21 Lehninger biochem test bank
h h h h h
1.hWhichhofhthehfollowinghishnothrequiredhinhthehsynthesishofhfa yhacids?h
A)hAcetyl-CoAh
B)hBio nh
C)hHCO3-h(CO2)h
D)hMalonyl-CoAh
E)hNADHh-hE
2.hWhichhofhthehfollowinghishnothtruehofhthehreac onhproducinghmalonyl-CoAhduringhfa yhacidhsynthesis?h
A)hIthishs mulatedhbyhcitrate.h
B)hIthrequireshacylhcarrierhproteinh(ACP).h
C)hIthrequireshCO2h(orhbicarbonate).h
D)hOnehmolehofhATPhishconvertedhtohADPh+hPihforheachhmalonyl-CoAhsynthesized.
E)hThehcofactorhishbio n.h-hB
3.hIfhmalonyl-CoAhishsynthesizedhfromh14CO2handhunlabeledhacetyl-
CoA,handhthehlabeledhmalonatehishthenhusedhforhfa yhacidhsynthesis,hthehfinalhproducth(fa yhacid)hwillhhav
ehradioac vehcarbonhin:h
A)heveryhC.h
B)heveryheven-numberedhC-atom.h
C)heveryhodd-numberedhC-atom.h
D)hnohparthofhthehmolecule.h
E)honlyhthehomega-carbonhatomh(farthesthcarbonhfromhC-1).h-hD
4.hWhichhonehofhthehfollowinghstatementshbesthapplieshtohsynthesishofhfa yhacidshinhE.hcolihextracts?
, A)hAcylhintermediatesharehthioestershofhahlowhmolecularhweighthproteinhcalledhacylhcarrierhprotein.h
B)hCO2horhHCO3-hishessen al.h
C)hReducinghequivalentsharehprovidedhbyhNADPH.
D)hThehul matehsourcehofhallhthehcarbonhatomshinhthehfa yhacidhproducthishacetyl-CoA.h
E)hAllhofhthehaboveh-hE
5.hInhcomparinghfa yhacidhbiosynthesishwithhbeta-
oxida onhofhfa yhacids,hwhichhofhthehfollowinghstatementshishincorrect?h
A)hAhthioesterhderiva vehofhcrotonichacidh(trans-2-
butenoichacid)hishanhintermediatehinhthehsynthe chpath,hbuthnothinhthehdegrada vehpath.h
B)hAhthioesterhderiva vehofhD-beta-
hydroxybutyratehishanhintermediatehinhthehsynthe chpath,hnothinhthehdegrada vehpath.h
C)hFa yhacidhbiosynthesishuseshNADPHhexclusively,hwhereashbeta-oxida onhuseshNAD+hexclusively.h
D)hFa yhacidhdegrada onhishcatalyzedhbyhcytosolichenzymes;hfa yhacidhsynthesishbyhmitochondrialhenzym
es.h
E)hThehcondensa onhofhtwohmoleshofhacetyl-
CoAhinhthehpresencehofhahcrudehextracthishmorehrapidhinhbicarbonatehbufferhthanhinhphosphatehbufferhathth
ehsamehpH;hthehcleavagehofhacetoacetyl-CoAhproceedshequallyhwellhinheitherhbuffer.h-hD
6.hWhichhofhthehfollowinghishnothtruehofhthehfa yhacidhsynthasehandhthehfa yhacidhbeta-
oxida onhsystems?h
A)hAhderiva vehofhthehvitaminhpantothenichacidhishinvolved.h
B)hAcyl-CoAhderiva vesharehintermediates.h
C)hDoublehbondsharehoxidizedhorhreducedhbyhpyridinehnucleo dehcoenzymes.h
D)hThehprocesseshoccurhinhdifferenthcellularhcompartments.
E)hThehprocesseshoccurhinhthehmitochondrialhmatrix.h-hE
7.hThehrate-limi nghstephinhfa yhacidhsynthesishis:h
h h h h h
1.hWhichhofhthehfollowinghishnothrequiredhinhthehsynthesishofhfa yhacids?h
A)hAcetyl-CoAh
B)hBio nh
C)hHCO3-h(CO2)h
D)hMalonyl-CoAh
E)hNADHh-hE
2.hWhichhofhthehfollowinghishnothtruehofhthehreac onhproducinghmalonyl-CoAhduringhfa yhacidhsynthesis?h
A)hIthishs mulatedhbyhcitrate.h
B)hIthrequireshacylhcarrierhproteinh(ACP).h
C)hIthrequireshCO2h(orhbicarbonate).h
D)hOnehmolehofhATPhishconvertedhtohADPh+hPihforheachhmalonyl-CoAhsynthesized.
E)hThehcofactorhishbio n.h-hB
3.hIfhmalonyl-CoAhishsynthesizedhfromh14CO2handhunlabeledhacetyl-
CoA,handhthehlabeledhmalonatehishthenhusedhforhfa yhacidhsynthesis,hthehfinalhproducth(fa yhacid)hwillhhav
ehradioac vehcarbonhin:h
A)heveryhC.h
B)heveryheven-numberedhC-atom.h
C)heveryhodd-numberedhC-atom.h
D)hnohparthofhthehmolecule.h
E)honlyhthehomega-carbonhatomh(farthesthcarbonhfromhC-1).h-hD
4.hWhichhonehofhthehfollowinghstatementshbesthapplieshtohsynthesishofhfa yhacidshinhE.hcolihextracts?
, A)hAcylhintermediatesharehthioestershofhahlowhmolecularhweighthproteinhcalledhacylhcarrierhprotein.h
B)hCO2horhHCO3-hishessen al.h
C)hReducinghequivalentsharehprovidedhbyhNADPH.
D)hThehul matehsourcehofhallhthehcarbonhatomshinhthehfa yhacidhproducthishacetyl-CoA.h
E)hAllhofhthehaboveh-hE
5.hInhcomparinghfa yhacidhbiosynthesishwithhbeta-
oxida onhofhfa yhacids,hwhichhofhthehfollowinghstatementshishincorrect?h
A)hAhthioesterhderiva vehofhcrotonichacidh(trans-2-
butenoichacid)hishanhintermediatehinhthehsynthe chpath,hbuthnothinhthehdegrada vehpath.h
B)hAhthioesterhderiva vehofhD-beta-
hydroxybutyratehishanhintermediatehinhthehsynthe chpath,hnothinhthehdegrada vehpath.h
C)hFa yhacidhbiosynthesishuseshNADPHhexclusively,hwhereashbeta-oxida onhuseshNAD+hexclusively.h
D)hFa yhacidhdegrada onhishcatalyzedhbyhcytosolichenzymes;hfa yhacidhsynthesishbyhmitochondrialhenzym
es.h
E)hThehcondensa onhofhtwohmoleshofhacetyl-
CoAhinhthehpresencehofhahcrudehextracthishmorehrapidhinhbicarbonatehbufferhthanhinhphosphatehbufferhathth
ehsamehpH;hthehcleavagehofhacetoacetyl-CoAhproceedshequallyhwellhinheitherhbuffer.h-hD
6.hWhichhofhthehfollowinghishnothtruehofhthehfa yhacidhsynthasehandhthehfa yhacidhbeta-
oxida onhsystems?h
A)hAhderiva vehofhthehvitaminhpantothenichacidhishinvolved.h
B)hAcyl-CoAhderiva vesharehintermediates.h
C)hDoublehbondsharehoxidizedhorhreducedhbyhpyridinehnucleo dehcoenzymes.h
D)hThehprocesseshoccurhinhdifferenthcellularhcompartments.
E)hThehprocesseshoccurhinhthehmitochondrialhmatrix.h-hE
7.hThehrate-limi nghstephinhfa yhacidhsynthesishis:h
