©SIRJOEL EXAM SOLUTIONS 2024/2025
ALL RIGHTS RESERVED.
Pathophysiology (WCU w/ Song) Ch 14
Exam Questions And Answers
Hemostasis - Answers✔Prevention of blood loss after blood vessel is damaged. This process is
accomplished by a complex interaction with the vessel wall, circulating platelets, and plasma
coagulation proteins. (3 steps)
Primary hemostasis - Answers✔The initial response to vascular injury involving the interaction
between platelets and endothelium of injured vessel.
Describe the process of primary hemostasis - Answers✔The injured vessels vasoconstricts and
prevent blood loss. The platelet plug forms when platelets adhere to endothelial collagen and
clump together at the site of injury.
Secondary hemostasis - Answers✔Involves the formation of a fibrin cloth through intrinsic and
extrinsic pathways; coagulation.
Describe the process of secondary hemostasis - Answers✔Clotting factors are activated via the
intrinsic and extrinsic pathways that catalyze the conversion of fibrinogen into fibrin. A fibrin
clot or coagulation forms at the site of injury to maintain hemostasis.
1|Page
, ©SIRJOEL EXAM SOLUTIONS 2024/2025
ALL RIGHTS RESERVED.
Clot retraction stage - Answers✔The final stage of clot formation. Components of a fibrin clot
(platelet plug, fibrin strands, and trapped RBC) are compressed to form a firm clot.
Where are coagulation factors synthesized? - Answers✔liver
Coagulation factors - Answers✔-Factors requiring vitamin K: 2, 7, 9, 10
-extrinsic pathway factors :3, 7
-intrinsic pathway factors: 8, 9, 11, 12
-common pathway factors: 1, 2, 5, 10, 13
Intrinsic pathway of coagulation - Answers✔Blood comes in contact with altered vascular
endothelium. Factor XII initiate the pathway.
Extrinsic pathway of coagulation - Answers✔Happens when vascular wall is is injured.Factor III
activates this a pathway.
Common final pathway of coagulation - Answers✔Initiated by factor X, factor X is also found in
intrinsic and extrinsic pathways.
Vitamin C and antithrombin III (ATIII) - Answers✔Promote anticoagulation
Fibrinolysis - Answers✔Dissolution of a clot, occurs as the fibrin clot is forming.
Process of fibrinolysis - Answers✔Factor XII, HMWK, Kallikrein, and thrombin release
plasminogen activators to cleave plasminogen (inactive). Plasminogen forms plasmin (active).
Plasmin will digest fibrinogen and fibrin and inactivates coagulation factor V and VII.
2|Page
ALL RIGHTS RESERVED.
Pathophysiology (WCU w/ Song) Ch 14
Exam Questions And Answers
Hemostasis - Answers✔Prevention of blood loss after blood vessel is damaged. This process is
accomplished by a complex interaction with the vessel wall, circulating platelets, and plasma
coagulation proteins. (3 steps)
Primary hemostasis - Answers✔The initial response to vascular injury involving the interaction
between platelets and endothelium of injured vessel.
Describe the process of primary hemostasis - Answers✔The injured vessels vasoconstricts and
prevent blood loss. The platelet plug forms when platelets adhere to endothelial collagen and
clump together at the site of injury.
Secondary hemostasis - Answers✔Involves the formation of a fibrin cloth through intrinsic and
extrinsic pathways; coagulation.
Describe the process of secondary hemostasis - Answers✔Clotting factors are activated via the
intrinsic and extrinsic pathways that catalyze the conversion of fibrinogen into fibrin. A fibrin
clot or coagulation forms at the site of injury to maintain hemostasis.
1|Page
, ©SIRJOEL EXAM SOLUTIONS 2024/2025
ALL RIGHTS RESERVED.
Clot retraction stage - Answers✔The final stage of clot formation. Components of a fibrin clot
(platelet plug, fibrin strands, and trapped RBC) are compressed to form a firm clot.
Where are coagulation factors synthesized? - Answers✔liver
Coagulation factors - Answers✔-Factors requiring vitamin K: 2, 7, 9, 10
-extrinsic pathway factors :3, 7
-intrinsic pathway factors: 8, 9, 11, 12
-common pathway factors: 1, 2, 5, 10, 13
Intrinsic pathway of coagulation - Answers✔Blood comes in contact with altered vascular
endothelium. Factor XII initiate the pathway.
Extrinsic pathway of coagulation - Answers✔Happens when vascular wall is is injured.Factor III
activates this a pathway.
Common final pathway of coagulation - Answers✔Initiated by factor X, factor X is also found in
intrinsic and extrinsic pathways.
Vitamin C and antithrombin III (ATIII) - Answers✔Promote anticoagulation
Fibrinolysis - Answers✔Dissolution of a clot, occurs as the fibrin clot is forming.
Process of fibrinolysis - Answers✔Factor XII, HMWK, Kallikrein, and thrombin release
plasminogen activators to cleave plasminogen (inactive). Plasminogen forms plasmin (active).
Plasmin will digest fibrinogen and fibrin and inactivates coagulation factor V and VII.
2|Page
