Test bank for Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 8th Edition by Nader Rifai, PhD Chapters 1 - 49

Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8 th Edition Test Bank Table of contents: I. Principles Of Laboratory Medicine Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques Chapter 3. Clinical Evaluation of Methods Chapter 4. Evidence-Based Laboratory Medicine Chapter 5. Establishment and Use of Reference Values Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables Chapter 7. Quality Management II. Analytical Techniques And Instrumentation Chapter 8. Principles of Basic Techniques and Laboratory Safety Chapter 9. Optical Techniques Chapter 10. Electrochemistry and Chemical Sensors Chapter 11. Electrophoresis Chapter 12. Chromatography Chapter 13. Mass Spectrometry Chapter 14. Enzyme and Rate Analyses Chapter 15. Immunochemical Techniques Chapter 16 Automation Chapter 17. Point-of-Care Instrumentation III. Analytes Chapter 18. Amino Acids, Peptides, and Proteins Chapter 19. Serum Enzymes Chapter 20. Tumor Markers and Cancer Genes Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid Chapter 22. Carbohydrates Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors Chapter 24. Electrolytes and Blood Gases Chapter 25. Hormones Chapter 26. Catecholamines and Serotonin Chapter 27. Vitamins, Trace Elements, Nutritional Assessment Chapter 28. Hemoglobin, Iron, and Bilirubin Chapter 29. Porphyrins and Porphyrias Chapter 30. Therapeutic Drugs and Their Management Chapter 31. Clinical Toxicology Chapter 32. Toxic Metals IV. Pathophysiology Chapter 33. Diabetes Chapter 34. Cardiovascular Disease Chapter 35. Kidney Disease Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism Chapter 37. Liver Disease Chapter 38. Gastrointestinal and Pancreatic Diseases Chapter 39. Disorders of Bone and Mineral Metabolism Chapter 40. Disorders of the Pituitary Gland Chapter 41. Disorders of the Adrenal Cortex Chapter 42. Thyroid Disorders Chapter 43. Reproduction-Related Disorders Chapter 44. Pregnancy and Prenatal Testing Chapter 45. Newborn Screening and Inborn Errors of Metabolism Chapter 46. Pharmacogenetics V. Molecular Diagnostics Chapter 47. Principles of Molecular Biology Chapter 48. Nucleic Acid Techniques and Applications Chapter 49. Genomes and Nucleic Acid Alterations Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine Test Bank MULTIPLE CHOICE 1. An individual working in a clinical chemistry laboratory is married to a sales representative who works for a company that sells chemistry laboratory supplies. When the laboratory manager requests a list of needed supplies, cost of supplies, and vendors, this individual onlyrecommends the spouse’s company as the vendor. This is considered to be a(n): a. accounting issue. b. possible conflict of interest. c. maintenance of confidentiality issue. d. problem with resource allocation. ANS: B Concern has been raised over the interrelationships between practitioners in the medical fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession. Similarly, relationships have been scrutinized between clinical laboratorians and manufacturers and providers of diagnostic equipment and supplies. These concerns led the National Institutes of Health (NIH) in 1995 to require official institutional review of financial disclosure by researchers and management of situations in which disclosure indicates potentialconflicts of interest. DIF: 1 REF: Page 4-5 OBJ: 6 | 7 2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the pain following her recent surgery. A friend of the patient claims that the same painkiller“worked wonders” to reduce her pain after the same surgery. The physician states that the difference in the effect of the drug might be caused by , which is studied in pharmacogenetics. a. epidemiology b. an inherited disease c. a conflict of interest d. a genetic variation in drug-metabolizing enzymes ANS: D Pharmacogenetics is the study of the genetic variation of drug metabolism betweenindividuals. DIF: 1 REF: Page 3 OBJ: 1 3. John works in a molecular diagnostics laboratory and receives a blood sample that has the name of a close friend printed on the bar-coded label. The genetic test that is ordered on thefriend’s sample would provide diagnostic information about a disorder that has a poor prognosis, and the test is usually performed by John. He asks a fellow employee to analyzethe sample for him and not divulge the results. This ethical issue concerns: a. confidentiality of patient genetic and medical information. b. a conflict of interest. c. resource allocation. d. diagnostic accuracy. ANS: A Clinical laboratorians have long been responsible for maintaining the confidentiality of alllaboratory results, a situation made even more critical with the advent of increasingly powerful genetic testing. DIF: 1 REF: Page 4 OBJ: 6 | 7 4. Molecular diagnostic testing methods and results can be: a. qualitative only. b. quantitative only. c. either qualitative or quantitative. ANS: C Molecular diagnostic methods can be either qualitative or quantitative in nature, depending onthe clinical need. DIF: 1 REF: Page 3 OBJ: 5 5. Clinical epidemiology, which is the study of the patterns, causes, and effects of health and disease in certain populations, has provided the clinical laboratory with methods that evaluatethe effects and outcomes of laboratory testing. This allows for a more effective: a. process of determining the cost of the testing methods. b. selection and interpretation of laboratory tests. c. determination of the boundaries between the components of the clinical lab. d. conduct assessment. ANS: A Clinical epidemiologists have introduced methods to evaluate the effects and value of laboratory testing in healthcare. These developments are expected to play an increasing role inthe selection and interpretation of laboratory tests. DIF: 1 REF: Page 3 OBJ: 4 6. Analysis of which one of the following by molecular diagnostic methods provides a measureof processes that are ongoing at the time of blood sampling? a. Genetic variation in an individual’s response to a drug b. Circulating plasma nucleic acids c. Malignant lymphomas d. Histocompatibility ANS: B Molecular diagnostics, given its very high sensitivity, has been applied to the study of plasma nucleic acids (or circulating nucleic acids). Plasma nucleic acids analysis has been made possible by the discovery that dying cells in the body release their DNA and RNA into the extracellular compartment and ultimately into the bloodstream, where they can be detected and analyzed. Given their short half-life in circulation (less than 24 hours), plasma nucleic acids provide a measure of processes that are ongoing at the time of blood sampling.