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21
Ter
m
Define evidence-based medicine/practice
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Early detection and prevention (screening tests)
Appropriate patient education regarding healthy lifestyle, the impact of stress, and risk
factor modification
Risks and benefits of immunization & immunization schedules (children, foreign
travelers, etc.)
Occupational and environmental exposures
Psychological manifestations of illness and injury
,• Effects of aging and changing family roles on health
maintenance and disease prevention
• Signs of abuse and neglect
• Barriers to care
"A systematic approach to clinical problem solving which allows the
integration of the best available research evidence with
clinical expertise and patient values."
"Making a conscientious effort to base clinical decisions on
research that is most likely to be free from bias, and using
interventions most likely to
improve how long or well patients live."
• Independent variables are the factors manipulated by the
investigator
• Dependent variables are measured data
• They are ultimately statistically evaluated for significance
The cohorts need to be as similar as possible regarding a multitude of
variables
• Placement into a specific cohort must not be biased by the
examiner or subject
• Size of cohort
• Age
• Physical characteristics
• Comorbidities
• Data is gathered in an unbiased fashion involving
prospective randomized groups of statistically comparable
populations
• Ideally the observer does not know what treatment was
rendered to eliminate bias ("blinded")
• Some element of bias involved whenever a procedure is
performed -neither patient nor examiners are able to be blinded
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, 2 of 21
Term
Differentiate patient-related variables and clinician-related
variables in medicine
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Subjective - coming from patient
• Information relayed by the patient
• Things the patient feels (typically not quantifiable)
• Medical history
Objective
• Information obtained by the examine
• Able to quantify
• Vital signs, physical examination, etc.
Pertinent positive = the presence of a sign or symptom that helps
substantiate a diagnosis or condition, aid in dx, signs or symptoms, possible
dx
Pertinent negative = the absence of a sign or symptom that helps
substantiate a diagnosis or condition, rule out other dx, not symptoms or
signs
Patient-related variables- level of consciousness,
education level, language barriers, cultural variations
Clinician-related variables- history taking skills, physical examination
skills, quality/quantity of clinical training & experience, type of
patient and
diseases typically seen and treated in the clinician's practice