[Mock Boards] HEMA
1. Which of the following is the anticoagulant of choice for most coagulation
studies
A. Sodiumoxalate
B. Heparin
C. SodiumCitrate
D. EDTA
E. Noneofthechoices correct answers C. SodiumCitrate
2.What would be the most likely designation by the WHO for the FAB
AML M3 by the French-American-British classification?
A. AMLwitht(15;17)
B. AMLwitht(8;21)
C. AMLwithmixedlineage
D. AMLwithinv(16)
E. noneofthesechoices correct answers A. AMLwitht(15;17)
Which of the following findings would be most typical of severe
septicemia?
A. Toxicgranulation
B. Hypersegmentation
C. Auerrods
D. Alder-Reillyanomaly
E. noneofthesechoices correct answers A. Toxicgranulation
The absence of the Philadelphia chromosome in granulocytic leukemia
suggests:
F. GoodPrognosis
G. Rapidprogressionofthedisease
H. Excellentresponsetotherapy
I. Apolyclonalorigintothedisease
J.Conversionfromanothermyeloproliferativedisorder correct
answers B. Rapidprogressionofthedisease
Approximately of the total number of platelets circulate in
the systemic circulation?
K. One-fourth
L. One-half
M. One-third
N. Two-third
O. noneofthesechoices correct answers D. Two-third
Which results are associated with hemophilia A?
P. ProlongedAPTT,normalPT
Q. ProlongedAPTTandPT
,C. ProlongedPT,normalAPTT
D. NormalPTandAPTT
E. noneofthesechoices correct answers A. ProlongedAPTT,normalPT
Primary granules in the neutrophil appear at which stage:
A. Myeloblast
B. Myelocyte
C. Metamyelocyte
D. Promyelocyte
E. noneofthesechoices correct answers D. Promyelocyte
Platelet function is impaired after ingesting aspirin because:
F.Aspirinblockscertainglycoproteinreceptorsonthesurfaceofthe
platelet B.
Aspirininterfereswithliversynthesisofanumberofcoagulationfactor
s
C. Aspirinaltersthestructureoftheglycocalyx
D. Aspirin decreases thromboxaneA2 formationby inhibiting
cyclooxygenase correct answers D. Aspirin decreases thromboxaneA2
formationby inhibiting cyclooxygenase
Which of the following is most closely associated with acute promyelocytic
leukemia?
G. Ringedsideroblasts
H. Micromegakaryocytes
I. DisseminatedIntravascularCoagulation
J. Philadelphiachromosome
K. noneofthesechoices correct answers C.
DisseminatedIntravascularCoagulation
The test reagent in APTT contains which of the following substance(s)?
1. Citrated plasma, 2. Calcium ions, 3. Tissue thromboplastin, 4.
Phospholipids
L. 1,2,and3
M.2and4
N. 1and3
O. Only4 correct answers B. 2and4
Which of the following abnormalities is consistent with the
presence of lupus anticoagulant?
P. ShortenedAPTT/bleedingcomplications
Q. ProlongedAPTT/thrombosis
R. ProlongedAPTT/thrombocytosis
S. Thrombocytosis/thrombosis
T. noneofthesechoices correct answers B.
ProlongedAPTT/thrombosis
Platelet aggregation studies revealed normal aggregation curves with
collagen, epinephrine, and ADP, but an abnormal aggregation curve with
ristocetin. Based on these findings, what is the differential diagnosis?
U. VonWillebranddiseaseandBernard-Souliersyndrome
V. Glanzmann'sthrombastheniaandvonWillebranddisease
, C. StoragepooldiseaseandGlanzmann'sthrombasthenia
D. Bernard-Souliersyndromeandstoragepooldisease
E. noneofthesechoices correct answers A.
VonWillebranddiseaseandBernard- Souliersyndrome
The Philadelphia chromosome is formed by a translocation between
the:
A. longarmofchromosome21andlongarmofchromosome9
B. longarmofchromosome21andshortarmofchromosome6
C. longarmofchromosome22andlongarmofchromosome9
D. longarmofchromosome22andshortarmofchromosome6
E.noneofthesechoices correct answers C.
longarmofchromosome22andlongarmofchromos
ome9
Platelet adhesion is abnormal in Bernard-
Soulier disease because:
F. Aplasmafactorneededforplateletadhesionisab
sent
G. Antibodiestophospholipidarepresent
H. GlycoproteinIboftheplateletmembraneisdefec
tive
I. Abnormalproteinsintheplasmacoattheplatelet
membrane
J.noneofthesechoices correct answers
C.
GlycoproteinIboftheplateletmembraneisdef
ective
Morphologic variants of plasma cells do
not include:
K. Flamecells
L. Grapecells
M. Morulacells
N. Gauchercells
O. noneofthesechoices correct answers D.
Gauchercells
Which ratio of anticoagulant to blood is
correct for coagulation studies
P. 1:4
Q. 1:9
R. 1:5
S. 1:10
T. noneofthesechoices correct answers B.
1:9
In differentiating the maturation stages of the megakaryocytic cells,
emphasis should be placed on the .
U. Cytoplasmicappearance
1. Which of the following is the anticoagulant of choice for most coagulation
studies
A. Sodiumoxalate
B. Heparin
C. SodiumCitrate
D. EDTA
E. Noneofthechoices correct answers C. SodiumCitrate
2.What would be the most likely designation by the WHO for the FAB
AML M3 by the French-American-British classification?
A. AMLwitht(15;17)
B. AMLwitht(8;21)
C. AMLwithmixedlineage
D. AMLwithinv(16)
E. noneofthesechoices correct answers A. AMLwitht(15;17)
Which of the following findings would be most typical of severe
septicemia?
A. Toxicgranulation
B. Hypersegmentation
C. Auerrods
D. Alder-Reillyanomaly
E. noneofthesechoices correct answers A. Toxicgranulation
The absence of the Philadelphia chromosome in granulocytic leukemia
suggests:
F. GoodPrognosis
G. Rapidprogressionofthedisease
H. Excellentresponsetotherapy
I. Apolyclonalorigintothedisease
J.Conversionfromanothermyeloproliferativedisorder correct
answers B. Rapidprogressionofthedisease
Approximately of the total number of platelets circulate in
the systemic circulation?
K. One-fourth
L. One-half
M. One-third
N. Two-third
O. noneofthesechoices correct answers D. Two-third
Which results are associated with hemophilia A?
P. ProlongedAPTT,normalPT
Q. ProlongedAPTTandPT
,C. ProlongedPT,normalAPTT
D. NormalPTandAPTT
E. noneofthesechoices correct answers A. ProlongedAPTT,normalPT
Primary granules in the neutrophil appear at which stage:
A. Myeloblast
B. Myelocyte
C. Metamyelocyte
D. Promyelocyte
E. noneofthesechoices correct answers D. Promyelocyte
Platelet function is impaired after ingesting aspirin because:
F.Aspirinblockscertainglycoproteinreceptorsonthesurfaceofthe
platelet B.
Aspirininterfereswithliversynthesisofanumberofcoagulationfactor
s
C. Aspirinaltersthestructureoftheglycocalyx
D. Aspirin decreases thromboxaneA2 formationby inhibiting
cyclooxygenase correct answers D. Aspirin decreases thromboxaneA2
formationby inhibiting cyclooxygenase
Which of the following is most closely associated with acute promyelocytic
leukemia?
G. Ringedsideroblasts
H. Micromegakaryocytes
I. DisseminatedIntravascularCoagulation
J. Philadelphiachromosome
K. noneofthesechoices correct answers C.
DisseminatedIntravascularCoagulation
The test reagent in APTT contains which of the following substance(s)?
1. Citrated plasma, 2. Calcium ions, 3. Tissue thromboplastin, 4.
Phospholipids
L. 1,2,and3
M.2and4
N. 1and3
O. Only4 correct answers B. 2and4
Which of the following abnormalities is consistent with the
presence of lupus anticoagulant?
P. ShortenedAPTT/bleedingcomplications
Q. ProlongedAPTT/thrombosis
R. ProlongedAPTT/thrombocytosis
S. Thrombocytosis/thrombosis
T. noneofthesechoices correct answers B.
ProlongedAPTT/thrombosis
Platelet aggregation studies revealed normal aggregation curves with
collagen, epinephrine, and ADP, but an abnormal aggregation curve with
ristocetin. Based on these findings, what is the differential diagnosis?
U. VonWillebranddiseaseandBernard-Souliersyndrome
V. Glanzmann'sthrombastheniaandvonWillebranddisease
, C. StoragepooldiseaseandGlanzmann'sthrombasthenia
D. Bernard-Souliersyndromeandstoragepooldisease
E. noneofthesechoices correct answers A.
VonWillebranddiseaseandBernard- Souliersyndrome
The Philadelphia chromosome is formed by a translocation between
the:
A. longarmofchromosome21andlongarmofchromosome9
B. longarmofchromosome21andshortarmofchromosome6
C. longarmofchromosome22andlongarmofchromosome9
D. longarmofchromosome22andshortarmofchromosome6
E.noneofthesechoices correct answers C.
longarmofchromosome22andlongarmofchromos
ome9
Platelet adhesion is abnormal in Bernard-
Soulier disease because:
F. Aplasmafactorneededforplateletadhesionisab
sent
G. Antibodiestophospholipidarepresent
H. GlycoproteinIboftheplateletmembraneisdefec
tive
I. Abnormalproteinsintheplasmacoattheplatelet
membrane
J.noneofthesechoices correct answers
C.
GlycoproteinIboftheplateletmembraneisdef
ective
Morphologic variants of plasma cells do
not include:
K. Flamecells
L. Grapecells
M. Morulacells
N. Gauchercells
O. noneofthesechoices correct answers D.
Gauchercells
Which ratio of anticoagulant to blood is
correct for coagulation studies
P. 1:4
Q. 1:9
R. 1:5
S. 1:10
T. noneofthesechoices correct answers B.
1:9
In differentiating the maturation stages of the megakaryocytic cells,
emphasis should be placed on the .
U. Cytoplasmicappearance
