Questions and Answers 100% Pass
How do benzodiazepine help with anxiety? - ANSWER✔✔-Benzodiazepine target
GABA neurotransmission via the PAM (positive allosteric modulation
Allodynia - ANSWER✔✔-Pain due to a stimulus that does not normally provoke pain
Hyperalgesia - ANSWER✔✔-Increased pain from a stimulus that normally provokes
pain
Nocioceptive pain - ANSWER✔✔-Pain that arises from actual or threatened damage to
non-neural tissue and is due to the aciviation of .....
Neuropathic pain - ANSWER✔✔-Pain created by a lesion or disease of the
somatosensory nervous system
Central Sensitization - ANSWER✔✔-Increased responsiveness of nocioceptive neurons
in the CNS to their normal or subthreshold afferent input.
Nocioceptor - ANSWER✔✔-A primary afferent (sensory) neuron that is only activated
by a noxious stimulus
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,Nocioception - ANSWER✔✔-The process by which a nocioceptor detects a noxious
stimulus and generates a signal (action potentials) that is propagated towards higher
centers in the nocioceptive pathway
Dorsal Root Ganglion (DRG) - ANSWER✔✔-Contains the cell bodies of primary
afferent neurons, proteins, including transmitters, receptors, and structural proteins, are
synthesized here and transported to peripheral and central terminals.
Interneurons - ANSWER✔✔-Neuron in the dorsal horn that receives input from PANS
and/ or interneurons, and projects up the spinal cord to higher processing centers
Spinothalamic tract - ANSWER✔✔-tract of neurons that project from the spinal cord to
the thalamus
Spinobulbar tracts - ANSWER✔✔-Several different tracts of neurons that project from
the spinal cord to brainstem nuclei
Somatosensory cortex - ANSWER✔✔-Region of the cerebral cortex that receives input
mainly from cutaneous sensory nerves; the cortex is topographically arranged, with
adjacent areas receiving input from adjacent body areas; stimulation of the
somatosensory cortex creates sensations from the body part that projects to it.
A-Beta fibers - ANSWER✔✔-detect small movements, light touch
A-Delta fibers - ANSWER✔✔-sense noxious mechanical stimuli and subnoxious
thermalstimuli
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, C-fibers - ANSWER✔✔-bare nerve endings that are only activated by noxious
mechanical, thermal, or chemical stimuli
Describe Neuropathic Pain - ANSWER✔✔-pain that arises from damage to, or
dysfunction of, any part of the peripheral or central nervous system
Describe normal pain - ANSWER✔✔-pain caused by activation of nociceptive nerve
fibers
What is Peripheral Nociceptive Pain due to? - ANSWER✔✔-Inflammation or
mechanical damage in tissues
What does Peripheral Nociceptive pain respond to - ANSWER✔✔-NSAIDS, opioids,
procedures
Give examples of peripheral nociceptive pain - ANSWER✔✔-Osteoarthritis,
Rheumatoid arthritis, Cancer pain
What is peripheral neuropathic pain due to? - ANSWER✔✔-Damage to, or dysfunction
of, peripheral nerves
What does peripheral neuropathic pain respond to? - ANSWER✔✔-both peripheral and
centrally acting pharmacologic therapies
Give examples of peripheral neuropathic pain - ANSWER✔✔-Diabetic neuropathic
pain, postherpetic neuralgia,
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