NSG 531 Pharm Exam 1 Questions and Correct Answers the Latest Update

what is the site of drug absorption cell membrane what is the building block of the cell membrane phospholipid phosphate head in contact with aqueous solution because it is hydrophilic (attracted to water) fatty acid tails hydrophobic (repel water) non-ionized not charged, always lipid soluble, can cross bilayer easily ionized charged; always water soluble, cannot cross membrane easily #Examify | #OnlineExams | #TestPrep | #StudyResources | #AcademicSuccess | #ExamPreparation | #QuizTime | #LearningTools | #Education | #StudentSupport Examify | Smart Grades | Latest update pH concentration of H+ ions; lower pH=higher hydrogen ion concentration pKa reflects the acidity of a particular molecule; he lower the pKa the stronger the acid (& greater ability to donate a proton) ALAN if pH<pKa environment is acidic. Acidic environment moves reaction to Left and Acid is Nonionized BRAIN if pH> pKa environment is basic. Basic environment moves reaction to the Right Acid is Ionized Base Nonionized Free drug and Albumin increased total drug concentration is associated with increased free drug in the plasma and decreased albumin. What do you need to do if patient is hypoalbuminemic decrease med dose to prevent drug toxicity (Esp if they have decreased liver and kidney function) #Examify | #OnlineExams | #TestPrep | #StudyResources | #AcademicSuccess | #ExamPreparation | #QuizTime | #LearningTools | #Education | #StudentSupport Examify | Smart Grades | Latest update high Ka associated with longer half-life because drugs are stuck to plasma proteins longer. Also means reaction is favored to the right (more drug on plasma protein, less free drug) high Kd associated with increased free drug bioavailabilit