2024 Newest|NR565 Advanced Pharmacology
Fundamentals| UPDATE| COMPLETE FREQUENTLY
TESTED QUESTIONS WITH VERIFIED
ANSWERS|GET IT 100% ACCURATE!!
•
Factors Affecting Drug Absorption - ✔✔ANSW✔✔..Rate
of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning
Factors Affecting Drug Distribution -
✔✔ANSW✔✔..Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
Febuxostat AE - ✔✔ANSW✔✔..LFTs elevated and gout
exacerbation
,Febuxostat Monitoring Parameters -
✔✔ANSW✔✔..Acquire LFTs at baseline
Febuxostat Prescribing Consideration - ✔✔ANSW✔✔..-
Caution if CrCl 15-29; caution if severe hepatic
impairment; caution if cardiovascular disease
-Patients should receive prophylactic NSAIDs or
colchicine for up to 6 months after starting treatment.
Fentanyl - ✔✔ANSW✔✔..A strong opioid analgesic with
a high milligram potency (about 100 times that of
morphine).
Fibric Acid Derivatives (Fibrates) - ✔✔ANSW✔✔..most
effective drugs for lowering TG levels.
Example Gemfibrozil
Fibric Acid Derivatives Adverse Effects -
✔✔ANSW✔✔..Myopathy; Hepatotoxicity; Rash; GI
disturbances
Fibric Acid Drug Interactions -
✔✔ANSW✔✔..Gemfibrozil displaces warfarin from
plasma albumin thereby increasing anticoagulant effects;
increases risk for statin induced myopathy
,Flumazenil - ✔✔ANSW✔✔..GABA receptor antagonist;
Reversal for Benzodiazepine overdose;
Full-practice scope - ✔✔ANSW✔✔..Nurse practitioners
have the autonomy to evaluate patients, diagnose, order
and interpret tests, initiate and manage treatments and
prescribe medications, including controlled substances
without physician oversight.
Function of Cytochrome P450 (CYP450) -
✔✔ANSW✔✔..responsible for phase 1 metabolism in
which drugs are oxidized, reduced, or hydrolyzed
Heart Failure Plan for CKD - ✔✔ANSW✔✔..ACEI or
ARB as first line; can add CCB or thiazide diuretic
Heart Failure Plan for Pregnancy -
✔✔ANSW✔✔..Labetolol
Heart Failure Treatment Plan - ✔✔ANSW✔✔..ACEI or
ARB as first line, plus beta blockers, diuretics, and others
as needed
, 120 mg per day of morphine milligram equivalents -
✔✔ANSW✔✔..Referral to a pain specialist is required
for patients who take this dose of Morphine Milligram
Equivalents
Absorption Interaction - ✔✔ANSW✔✔..result of a
change due to one medication's effect on another
medication's route of entry into the body.
ACE Inhibitor Drug Interactions -
✔✔ANSW✔✔..Diuretics may intensify first-dose
hypotension; other antihypertensive agents;
HYPERKALEMIA RISK: AVOID Drugs That Raise
Potassium Levels;
Lithium;
NSAIDS (may reduce antihypertensive effects of ACE I)
ACE Inhibitor Main AE - ✔✔ANSW✔✔..Cough;
Angioedema; First Dose Hypotension; Hyperkalemia
ACE Inhibitor Mechanism of Action -
✔✔ANSW✔✔..produce their beneficial effects and
adverse effects by (1) reducing levels of angiotensin II
(through inhibition of ACE) and (2) increasing levels of
bradykinin (through inhibition of kinase II)
Fundamentals| UPDATE| COMPLETE FREQUENTLY
TESTED QUESTIONS WITH VERIFIED
ANSWERS|GET IT 100% ACCURATE!!
•
Factors Affecting Drug Absorption - ✔✔ANSW✔✔..Rate
of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning
Factors Affecting Drug Distribution -
✔✔ANSW✔✔..Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
Febuxostat AE - ✔✔ANSW✔✔..LFTs elevated and gout
exacerbation
,Febuxostat Monitoring Parameters -
✔✔ANSW✔✔..Acquire LFTs at baseline
Febuxostat Prescribing Consideration - ✔✔ANSW✔✔..-
Caution if CrCl 15-29; caution if severe hepatic
impairment; caution if cardiovascular disease
-Patients should receive prophylactic NSAIDs or
colchicine for up to 6 months after starting treatment.
Fentanyl - ✔✔ANSW✔✔..A strong opioid analgesic with
a high milligram potency (about 100 times that of
morphine).
Fibric Acid Derivatives (Fibrates) - ✔✔ANSW✔✔..most
effective drugs for lowering TG levels.
Example Gemfibrozil
Fibric Acid Derivatives Adverse Effects -
✔✔ANSW✔✔..Myopathy; Hepatotoxicity; Rash; GI
disturbances
Fibric Acid Drug Interactions -
✔✔ANSW✔✔..Gemfibrozil displaces warfarin from
plasma albumin thereby increasing anticoagulant effects;
increases risk for statin induced myopathy
,Flumazenil - ✔✔ANSW✔✔..GABA receptor antagonist;
Reversal for Benzodiazepine overdose;
Full-practice scope - ✔✔ANSW✔✔..Nurse practitioners
have the autonomy to evaluate patients, diagnose, order
and interpret tests, initiate and manage treatments and
prescribe medications, including controlled substances
without physician oversight.
Function of Cytochrome P450 (CYP450) -
✔✔ANSW✔✔..responsible for phase 1 metabolism in
which drugs are oxidized, reduced, or hydrolyzed
Heart Failure Plan for CKD - ✔✔ANSW✔✔..ACEI or
ARB as first line; can add CCB or thiazide diuretic
Heart Failure Plan for Pregnancy -
✔✔ANSW✔✔..Labetolol
Heart Failure Treatment Plan - ✔✔ANSW✔✔..ACEI or
ARB as first line, plus beta blockers, diuretics, and others
as needed
, 120 mg per day of morphine milligram equivalents -
✔✔ANSW✔✔..Referral to a pain specialist is required
for patients who take this dose of Morphine Milligram
Equivalents
Absorption Interaction - ✔✔ANSW✔✔..result of a
change due to one medication's effect on another
medication's route of entry into the body.
ACE Inhibitor Drug Interactions -
✔✔ANSW✔✔..Diuretics may intensify first-dose
hypotension; other antihypertensive agents;
HYPERKALEMIA RISK: AVOID Drugs That Raise
Potassium Levels;
Lithium;
NSAIDS (may reduce antihypertensive effects of ACE I)
ACE Inhibitor Main AE - ✔✔ANSW✔✔..Cough;
Angioedema; First Dose Hypotension; Hyperkalemia
ACE Inhibitor Mechanism of Action -
✔✔ANSW✔✔..produce their beneficial effects and
adverse effects by (1) reducing levels of angiotensin II
(through inhibition of ACE) and (2) increasing levels of
bradykinin (through inhibition of kinase II)
