CMN 548 Unit 5 Exam
Questions and Complete
Solutions Graded A+
Potency - Answer: refers to the relative dose required to achieve certain effects, not to the efficacy of a
drug
Agonist (full agonist) - Answer: A drug that binds to a specific receptor producing an effect identical to
that usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics - Answer: The time course and intensity of a drug's effect/what the drug does to the
body
Pharmacokinetics - Answer: What the body does to a drug
Tolerance - Answer: Develops over time a need to use increased doses of a medication/drug to maintain
a clinical effect. Or, a decreased sensitivity to adverse effects of a drug
Stevens-Johnson Syndrome - Answer: A systemic, immune-mediated reaction that can be fatal or result
in permanent scarring or blindness
Antagonist - Answer: A compound that blinds to a receptor that blocks or reduces the action of another
substance at the receptor site
Hyponatremia - Answer: Common symptoms of this medication side effect include confusion, agitation,
and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - Answer: ratio of the median toxic dose to the median effective dose
,Somnolence - Answer: Daytime sleepiness
Black Box Warning - Answer: This warning reflects that a medication may cause a serious or even life-
threatening side effect
Partial or Mixed Agonist - Answer: A compound that elicits a partial pharmacological response at the
receptor site involved
Remission - Answer: The degree of improvement to below the syndromal threshold of a disorder
Paradoxical - Answer: A response to a drug that represents the clinical effect opposite of what is
expected
Inverse agonist - Answer: An agent that binds to the same receptor site as an agonist but produces the
opposite pharmacological effect
4 major transmitters - Answer: Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - Answer: affects mood, Psychosis, ADHD, Addiction
Serotonin transmitter affects? - Answer: Depression, aggression, OCD, Panic, GAD, Social Anxiety, PTSD,
Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - Answer: Affects mood, anxiety, psychosis, ADHD (part), drug withdrawal
GABA affects? - Answer: Fear, anxiety, worry
Irreversible MAOIs Types - Answer: MAOa and MAOb
, Irreversible MAOIs medications - Answer: Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? - Answer: because they
irreversibly inactivate MAOs, the therapeutic effect of a single dose of irreversible MAOIs may persist for
as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - Answer: orthostatic hypotension, insomnia,
weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - Answer: Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? - Answer: MAO activity recovers
completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - Answer: depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - Answer: Avoid caffeine
intake of 2L of fluid/day
Questions and Complete
Solutions Graded A+
Potency - Answer: refers to the relative dose required to achieve certain effects, not to the efficacy of a
drug
Agonist (full agonist) - Answer: A drug that binds to a specific receptor producing an effect identical to
that usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics - Answer: The time course and intensity of a drug's effect/what the drug does to the
body
Pharmacokinetics - Answer: What the body does to a drug
Tolerance - Answer: Develops over time a need to use increased doses of a medication/drug to maintain
a clinical effect. Or, a decreased sensitivity to adverse effects of a drug
Stevens-Johnson Syndrome - Answer: A systemic, immune-mediated reaction that can be fatal or result
in permanent scarring or blindness
Antagonist - Answer: A compound that blinds to a receptor that blocks or reduces the action of another
substance at the receptor site
Hyponatremia - Answer: Common symptoms of this medication side effect include confusion, agitation,
and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - Answer: ratio of the median toxic dose to the median effective dose
,Somnolence - Answer: Daytime sleepiness
Black Box Warning - Answer: This warning reflects that a medication may cause a serious or even life-
threatening side effect
Partial or Mixed Agonist - Answer: A compound that elicits a partial pharmacological response at the
receptor site involved
Remission - Answer: The degree of improvement to below the syndromal threshold of a disorder
Paradoxical - Answer: A response to a drug that represents the clinical effect opposite of what is
expected
Inverse agonist - Answer: An agent that binds to the same receptor site as an agonist but produces the
opposite pharmacological effect
4 major transmitters - Answer: Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - Answer: affects mood, Psychosis, ADHD, Addiction
Serotonin transmitter affects? - Answer: Depression, aggression, OCD, Panic, GAD, Social Anxiety, PTSD,
Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - Answer: Affects mood, anxiety, psychosis, ADHD (part), drug withdrawal
GABA affects? - Answer: Fear, anxiety, worry
Irreversible MAOIs Types - Answer: MAOa and MAOb
, Irreversible MAOIs medications - Answer: Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? - Answer: because they
irreversibly inactivate MAOs, the therapeutic effect of a single dose of irreversible MAOIs may persist for
as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - Answer: orthostatic hypotension, insomnia,
weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - Answer: Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? - Answer: MAO activity recovers
completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - Answer: depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - Answer: Avoid caffeine
intake of 2L of fluid/day
