NAPLEX Prep Study Materials with Case
Studies Q&A| Reviewed 2025| Graded A
1. A 45-year-old male patient with a history of hypertension and heart failure presents to the
clinic with a blood pressure of 160/100 mmHg. Which antihypertensive medication is most
appropriate to initiate therapy?
a. Amlodipine
b. Lisinopril
c. Metoprolol
d. Hydrochlorothiazide
e. Diltiazem
2. A 30-year-old female patient presents to the pharmacy with a prescription for levothyroxine.
Which counseling point is most important to provide her?
a. Take with food
b. Take at the same time each day, preferably on an empty stomach
c. Discontinue if you experience hair loss
d. This medication can be taken as needed
3. A 70-year-old male patient with a history of type 2 diabetes and chronic kidney disease is
started on metformin. What monitoring parameter is most critical for this patient?
a. Liver function tests
1
, b. Serum creatinine
c. Hemoglobin A1c
d. Serum electrolytes
4. A 25-year-old female with a recent diagnosis of multiple sclerosis is prescribed interferon
beta-1a. Which of the following adverse effects should she be counseled about?
a. Hyperglycemia
b. Injection site reactions
c. Weight gain
d. Hair loss
5. A patient is prescribed warfarin and is concerned about dietary restrictions. Which of the
following foods should the patient be advised to avoid?
a. Broccoli
b. Spinach
c. Carrots
d. Apples
6. A 60-year-old female with chronic obstructive pulmonary disease (COPD) is prescribed
tiotropium. Which counseling point should be emphasized?
a. This medication is taken once daily
b. This medication should be used during an acute attack
c. Discontinue if you experience a headache
2
, d. This medication is used as needed
7. A 50-year-old male with a history of atrial fibrillation is started on dabigatran. Which
statement about this medication is correct?
a. No monitoring of renal function is necessary
b. It must be taken with food
c. It is a direct oral anticoagulant (DOAC)
d. It is safe to use in patients with a prosthetic heart valve
8. A patient receiving therapy with clopidogrel is scheduled for surgery. What is the appropriate
action regarding this medication?
a. Continue clopidogrel up to the day of surgery
b. Discontinue clopidogrel 5 days before surgery
c. Switch to aspirin 1 day before surgery
d. Discontinue clopidogrel 2 days before surgery
9. A 35-year-old female patient with a history of migraines is prescribed topiramate. Which
counseling point is important for this patient?
a. This medication may cause weight gain
b. This medication can cause drowsiness
c. This medication may lead to cognitive side effects
d. This medication must be taken with food
3
, 10. A 40-year-old male presents to the clinic with new-onset asthma. Which of the following
medications is recommended as a first-line therapy for asthma management?
a. Short-acting beta-agonist (SABA)
b. Long-acting beta-agonist (LABA)
c. Inhaled corticosteroid (ICS)
d. Leukotriene receptor antagonist
11. A patient presents with a history of bipolar disorder and is prescribed lamotrigine. What is a
critical side effect to monitor for this medication?
a. Renal toxicity
b. Rash, including Stevens-Johnson syndrome
c. Liver toxicity
d. Weight gain
12. A 55-year-old female patient with osteoporosis is prescribed alendronate. What counseling
point should be emphasized?
a. Take with food
b. Remain upright for at least 30 minutes after taking
c. This medication can be taken at any time of day
d. This medication is taken weekly on the same day
13. A patient with a recent diagnosis of hyperlipidemia is prescribed atorvastatin. Which of the
following statements is true regarding this medication?
4
Studies Q&A| Reviewed 2025| Graded A
1. A 45-year-old male patient with a history of hypertension and heart failure presents to the
clinic with a blood pressure of 160/100 mmHg. Which antihypertensive medication is most
appropriate to initiate therapy?
a. Amlodipine
b. Lisinopril
c. Metoprolol
d. Hydrochlorothiazide
e. Diltiazem
2. A 30-year-old female patient presents to the pharmacy with a prescription for levothyroxine.
Which counseling point is most important to provide her?
a. Take with food
b. Take at the same time each day, preferably on an empty stomach
c. Discontinue if you experience hair loss
d. This medication can be taken as needed
3. A 70-year-old male patient with a history of type 2 diabetes and chronic kidney disease is
started on metformin. What monitoring parameter is most critical for this patient?
a. Liver function tests
1
, b. Serum creatinine
c. Hemoglobin A1c
d. Serum electrolytes
4. A 25-year-old female with a recent diagnosis of multiple sclerosis is prescribed interferon
beta-1a. Which of the following adverse effects should she be counseled about?
a. Hyperglycemia
b. Injection site reactions
c. Weight gain
d. Hair loss
5. A patient is prescribed warfarin and is concerned about dietary restrictions. Which of the
following foods should the patient be advised to avoid?
a. Broccoli
b. Spinach
c. Carrots
d. Apples
6. A 60-year-old female with chronic obstructive pulmonary disease (COPD) is prescribed
tiotropium. Which counseling point should be emphasized?
a. This medication is taken once daily
b. This medication should be used during an acute attack
c. Discontinue if you experience a headache
2
, d. This medication is used as needed
7. A 50-year-old male with a history of atrial fibrillation is started on dabigatran. Which
statement about this medication is correct?
a. No monitoring of renal function is necessary
b. It must be taken with food
c. It is a direct oral anticoagulant (DOAC)
d. It is safe to use in patients with a prosthetic heart valve
8. A patient receiving therapy with clopidogrel is scheduled for surgery. What is the appropriate
action regarding this medication?
a. Continue clopidogrel up to the day of surgery
b. Discontinue clopidogrel 5 days before surgery
c. Switch to aspirin 1 day before surgery
d. Discontinue clopidogrel 2 days before surgery
9. A 35-year-old female patient with a history of migraines is prescribed topiramate. Which
counseling point is important for this patient?
a. This medication may cause weight gain
b. This medication can cause drowsiness
c. This medication may lead to cognitive side effects
d. This medication must be taken with food
3
, 10. A 40-year-old male presents to the clinic with new-onset asthma. Which of the following
medications is recommended as a first-line therapy for asthma management?
a. Short-acting beta-agonist (SABA)
b. Long-acting beta-agonist (LABA)
c. Inhaled corticosteroid (ICS)
d. Leukotriene receptor antagonist
11. A patient presents with a history of bipolar disorder and is prescribed lamotrigine. What is a
critical side effect to monitor for this medication?
a. Renal toxicity
b. Rash, including Stevens-Johnson syndrome
c. Liver toxicity
d. Weight gain
12. A 55-year-old female patient with osteoporosis is prescribed alendronate. What counseling
point should be emphasized?
a. Take with food
b. Remain upright for at least 30 minutes after taking
c. This medication can be taken at any time of day
d. This medication is taken weekly on the same day
13. A patient with a recent diagnosis of hyperlipidemia is prescribed atorvastatin. Which of the
following statements is true regarding this medication?
4
