CMN 574 Rheumatologic Disorders Exam With
Complete Solutions
What is the peak onset of RA and who is most at risk?
-Answer Women are most at risk
Peak onset:
Women - 40-50s
Men - 60-80s
What is RA?
-Answer A chronic systemic inflammatory disease which manifests as synovitis of
multiple joints
What is the standard of care for RA?
-Answer Early aggressive treatment
What joints are usually affected with RA?
-Answer MCP, wrists, knees, ankles and MTP
T/F
Symmetric swelling of > bones w/ tenderness and pain are characteristic symptoms of
RA - Answer T
What is rheumatoid nodules? - Answer Nodules that are usually over bony prominences;
can be seen in lungs, sclera, and other tissues
, What is the most specific blood test for RA? - Answer Anti-CCP antibodies
T/F
Morning joint stiffness common and can last for >30min for RA - Answer T
LWD CS (prednisone 5-10mg) are often used as a bridge to ________ - Reduce the
disease activity until slower DMARDs take effect; produce a fast antiinflammatory effect
and slow articular erosion
RA and methotrexate - Initial synthetic DMARD choice; dose: 7.5mg/wk, max 20-25mg;
takes 2-6wks for effect of med
What are some SE of methotrexate? - Gastric irritation, stomatitis, and hepatotoxicity,
cytopenias
Sulfasalazine -Answer Second-line for RA; may cause hemolysis if pt has G6PD
TNF inhibitors -Answer Used in combination w/ methotrexate for RA if monotherapy is
ineffective
What is SLE? -Answer Inflammatory autoimmune disorder that affects multiple organ
systems
Why does it affect multiple organ systems? -Answer There is trapping of
antigen-antibody complexes in capillaries of visceral structures producing clinical
manifestations
Who does SLE affect? - Answer Predominantly affects more women than men and those
of AA race
Before the diagnosis of SLE can be made, you must check to see if_____ - Answer The
Complete Solutions
What is the peak onset of RA and who is most at risk?
-Answer Women are most at risk
Peak onset:
Women - 40-50s
Men - 60-80s
What is RA?
-Answer A chronic systemic inflammatory disease which manifests as synovitis of
multiple joints
What is the standard of care for RA?
-Answer Early aggressive treatment
What joints are usually affected with RA?
-Answer MCP, wrists, knees, ankles and MTP
T/F
Symmetric swelling of > bones w/ tenderness and pain are characteristic symptoms of
RA - Answer T
What is rheumatoid nodules? - Answer Nodules that are usually over bony prominences;
can be seen in lungs, sclera, and other tissues
, What is the most specific blood test for RA? - Answer Anti-CCP antibodies
T/F
Morning joint stiffness common and can last for >30min for RA - Answer T
LWD CS (prednisone 5-10mg) are often used as a bridge to ________ - Reduce the
disease activity until slower DMARDs take effect; produce a fast antiinflammatory effect
and slow articular erosion
RA and methotrexate - Initial synthetic DMARD choice; dose: 7.5mg/wk, max 20-25mg;
takes 2-6wks for effect of med
What are some SE of methotrexate? - Gastric irritation, stomatitis, and hepatotoxicity,
cytopenias
Sulfasalazine -Answer Second-line for RA; may cause hemolysis if pt has G6PD
TNF inhibitors -Answer Used in combination w/ methotrexate for RA if monotherapy is
ineffective
What is SLE? -Answer Inflammatory autoimmune disorder that affects multiple organ
systems
Why does it affect multiple organ systems? -Answer There is trapping of
antigen-antibody complexes in capillaries of visceral structures producing clinical
manifestations
Who does SLE affect? - Answer Predominantly affects more women than men and those
of AA race
Before the diagnosis of SLE can be made, you must check to see if_____ - Answer The
