Nurs 602- Pathophysiology RA questions with correct
answers
What is RA and what does it cause? Correct Answer-A chronic, immune
mediated inflammatory condition causing symmetric polyarthritis.
Where does RA most commonly manifest? Correct Answer-Hands and
feet.
Is RA a systemic or more regional disease? Correct Answer-Systemic
Risk factors for RA? (4) Correct Answer-Female sex, Age 30-50, 1st
relative with RA, gut microbiome dysbiosis.
What is the etiology of RA? Correct Answer-Environmental and genetic
factors.
How do genetics play a role in RA? What HLA allele is responsible?
Correct Answer-If a person has a relative with RA they are more likely
to develop the disease. This is due to the HLA-DR allele HLA-DRB1
What does the presence of HLA-DRB1 implicate? Correct Answer-The
patient is more likely going to have immune cells that have a hard time
differentiating between self and foreign antigen.
What environmental factors are correlated with RA Correct Answer-
Smoking, infections, and hormonal factors influencing auto-immunity.
, How does pregnancy affect RA? Correct Answer-Estriol diminishes the
pregnant woman's immune system causing a relief in symptoms for the
pregnancy but symptoms often get worse after delivery?
What is citrullunation? Correct Answer-The enzymatic conversion of
arginine to citruline in a protein.
Proteins that undergo citrullunation include....? Correct Answer-Type 2
collagen, fibrinogen, and vimentin.
What enzyme is responsible for citrullunation? Correct Answer-Peptydil
arginine deaminase (PAD)
How is peptydil arginine deaminase thought to be activated? Correct
Answer-Irritation in the mucosal lining of the lungs, gut and mouth by
smoke, dysbiosis, or periodontal disease.
What will antigen presenting cells do to contribute to RA if a person is
genetically predisposed? Correct Answer-The APC will recognize the
citrullinated proteins as foreign antigens and bring them to the lymphatic
system causing Th cells and B cells to proliferate and differentiate
creating anti-citrullated protein antibodies (ACPAs).
What are the two types of RA? What is the deciding factor between the
two? Correct Answer-Seropositive and seronegative. Seropositive has
the presence of anti-citrullinated protein antibodies or rheumatoid factor.
answers
What is RA and what does it cause? Correct Answer-A chronic, immune
mediated inflammatory condition causing symmetric polyarthritis.
Where does RA most commonly manifest? Correct Answer-Hands and
feet.
Is RA a systemic or more regional disease? Correct Answer-Systemic
Risk factors for RA? (4) Correct Answer-Female sex, Age 30-50, 1st
relative with RA, gut microbiome dysbiosis.
What is the etiology of RA? Correct Answer-Environmental and genetic
factors.
How do genetics play a role in RA? What HLA allele is responsible?
Correct Answer-If a person has a relative with RA they are more likely
to develop the disease. This is due to the HLA-DR allele HLA-DRB1
What does the presence of HLA-DRB1 implicate? Correct Answer-The
patient is more likely going to have immune cells that have a hard time
differentiating between self and foreign antigen.
What environmental factors are correlated with RA Correct Answer-
Smoking, infections, and hormonal factors influencing auto-immunity.
, How does pregnancy affect RA? Correct Answer-Estriol diminishes the
pregnant woman's immune system causing a relief in symptoms for the
pregnancy but symptoms often get worse after delivery?
What is citrullunation? Correct Answer-The enzymatic conversion of
arginine to citruline in a protein.
Proteins that undergo citrullunation include....? Correct Answer-Type 2
collagen, fibrinogen, and vimentin.
What enzyme is responsible for citrullunation? Correct Answer-Peptydil
arginine deaminase (PAD)
How is peptydil arginine deaminase thought to be activated? Correct
Answer-Irritation in the mucosal lining of the lungs, gut and mouth by
smoke, dysbiosis, or periodontal disease.
What will antigen presenting cells do to contribute to RA if a person is
genetically predisposed? Correct Answer-The APC will recognize the
citrullinated proteins as foreign antigens and bring them to the lymphatic
system causing Th cells and B cells to proliferate and differentiate
creating anti-citrullated protein antibodies (ACPAs).
What are the two types of RA? What is the deciding factor between the
two? Correct Answer-Seropositive and seronegative. Seropositive has
the presence of anti-citrullinated protein antibodies or rheumatoid factor.
