NR565 / NR565 Advanced i i i
i PharmacologyFundamentals Midterm / i i i
Final Exam| Questions and 100 %
i i i i i i
Correct Answers | Rated A Quiz bank |
i i i i i i i i
LATEST, | Chamberlain
i i i i i i
College i
1. Kasey ifractured ihis iankle iin itwo iplaces iand iis iasking ifor imedication ifor ihis ipain.
iTheiappropriate ifirst-line imedication iwould ibe:
- Acetaminophen iwith ihydrocodone i(Vicodin)
2. Jack, iage i8, ihas iattention ideficit idisorder i(ADD) iand iis iprescribed
imethylphenidatei(Ritalin). iHe iand ihis iparents ishould ibe ieducated iabout ithe iside
ieffects iof imethylphenidate, iwhich iare:
- Insomnia iand idecreased iappetite
3. Monitoring ifor ia ichild ion imethylphenidate ifor iattention ideficit ihyperactivity
idisorderi(ADHD) iincludes:
- ADHD isymptoms
- Routine iheight iand iweight ichecks
- Amount iof imethylphenidate ibeing iused
4. When iprescribing iAdderall i(amphetamine iand idextroamphetamine) ito iadults iwith
iADHDithe inurse ipractitioner iwill ineed ito imonitor:
- Blood ipressure
5. Common imistakes ipractitioners imake iin itreating ianxiety idisorders iinclude:
- Thinking ia ipartial iresponse ito imedication iis iacceptable
6. An iappropriate ifirst-line idrug ito itry ifor imild ito imoderate igeneralized ianxiety
idisorderiwould ibe:
- Buspirone i(Buspar)
7. An iappropriate idrug ito iinitially itreat ipanic idisorder iis:
- Diazepam i(Valium)
8. Prior ito istarting iantidepressants, ipatients ishould ihave ilaboratory itesting ito irule iout:
- Hypothyroidism
,9. David iis ia i34-year-old ipatient iwho iis istarting ion iparoxetine i(Paxil) ifor
idepression.iDavid's ieducation iregarding ihis imedication iwould iinclude:
- He imay iexperience isexual idysfunction ibeginning ia imonth iafter ihe istarts itherapy.
10. Jamison ihas ibeen iprescribed icitalopram i(Celexa) ito itreat ihis idepression. iEducation
iregarding ihow iquickly iselective iserotonin ireuptake iinhibitor i(SSRI) iantidepressants
iworkiwould ibe:
- Appetite iand iconcentration iimprove iin ithe ifirst i1 ito i2 iweeks.
11. The iracial idifference iin idrug ipharmacokinetics iseen iin iAmerican iIndian ior
iAlaskaniNatives iare:
- Largely iunknown idue ito ilack iof istudies iof ithis ipopulation
12. Pharmacokinetics iamong iAsians iare iuniversal ito iall ithe iAsian iethnic igroups.
A. True
B. False
13. Alterations iin idrug imetabolism iamong iAsians imay ilead ito:
- Slower imetabolism iof iantidepressants, irequiring ilower idoses
14. Asians ifrom iEastern iAsia iare iknown ito ibe ifast iacetylators. iFast iacetylators:
- Require ihigher idoses iof idrugs imetabolized iby iacetylization ito iachieve iefficacy
15. Hispanic inative ihealers i(curanderas):
A. Are inot iheavily iutilized iby iHispanics iwho iimmigrate ito ithe iUnited iStates
B. Use iherbs iand iteas iin itheir itreatment iof iillness
C. Provide iunsafe iadvice ito iHispanics iand ishould inot ibe itrusted
D. Need ito ibe ilicensed iin itheir ihome icountry iin iorder ito ipractice iin ithe iUnited iStates i
16. Genetic ipolymorphisms iaccount ifor idifferences iin imetabolism, iincluding:
- Poor imetabolizers, iwho ilack ia iworking ienzyme
- Intermediate imetabolizers, iwho ihave ione iworking, iwild-type iallele iand ione
imutantiallele
- Extensive imetabolizers, iwith itwo inormally ifunctioning ialleles
17. Up ito i21% iof iAsians iare iultra-rapid i2D6 imetabolizers, ileading ito:
- Increased idosages ineeded iof idrugs imetabolized iby i2D6, isuch ias ithe
iselectiveiserotonin ireuptake iinhibitors
18. Drugs ithat iuse iCYP i3A4 iisoenzymes ifor imetabolism imay:
- Induce ithe imetabolism iof ianother idrug
, - Inhibit ithe imetabolism iof ianother idrug
19. Rifampin iis ia inonspecific iCYP450 iinducer ithat imay:
- Induce ithe imetabolism iof idrugs, isuch ias ioral icontraceptives, ileading ito
itherapeuticifailure
20. Inhibition iof iP-glycoprotein iby ia idrug isuch ias iquinidine imay ilead ito:
- Increased ilevels iof ia ico-administered idrug, isuch ias idigoxin, ithat irequires
iP-iglycoprotein ifor iabsorption iand ielimination
21. Warfarin iresistance imay ibe iseen iin ipatients iwith iVCORC1 imutation, ileading ito:
- Decreased iresponse ito iwarfarin
22. Genetic itesting ifor iVCORC1 imutation ito iassess ipotential iwarfarin iresistance iis
irequirediprior ito iprescribing iwarfarin.
A. True
B. False
23. Pharmacogenetic itesting iis irequired iby ithe iU.S. iFood iand iDrug iAdministration
iprior itoiprescribing:
- Cetuximab
24. Carbamazepine ihas ia iBlack iBox iWarning irecommending itesting ifor ithe iHLA-
B*1502iallele iin ipatients iwith iAsian iancestry iprior ito istarting itherapy idue ito:
- Increased irisk ifor iStevens-Johnson isyndrome iin iAsian ipatients iwith iHLA-
B*1502iallele
25. A igenetic ivariation iin ihow ithe imetabolite iof ithe icancer idrug iirinotecan iSN-
38 iisiinactivated iby ithe ibody imay ilead ito
- Increased iadverse idrug ireactions, isuch ias ineutropenia
26. Patients iwho ihave ia ipoor imetabolism iphenotype iwill ihave:
- Slowed imetabolism iof ia iprodrug iinto ian iactive idrug, ileading ito iaccumulation
iofiprodrug
27. A ipatient's inutritional iintake iand ilaboratory iresults ireflect ihypoalbuminemia. iThis
iisicritical ito iprescribing ibecause:
- Distribution iof idrugs ito itarget itissue imay ibe iaffected.
28. Drugs ithat ihave ia isignificant ifirst-pass ieffect:
- Are irapidly imetabolized iby ithe iliver iand imay ihave ilittle iif iany idesired iaction
29. The iroute iof iexcretion iof ia ivolatile idrug iwill ilikely ibe ithe:
- Lungs
i PharmacologyFundamentals Midterm / i i i
Final Exam| Questions and 100 %
i i i i i i
Correct Answers | Rated A Quiz bank |
i i i i i i i i
LATEST, | Chamberlain
i i i i i i
College i
1. Kasey ifractured ihis iankle iin itwo iplaces iand iis iasking ifor imedication ifor ihis ipain.
iTheiappropriate ifirst-line imedication iwould ibe:
- Acetaminophen iwith ihydrocodone i(Vicodin)
2. Jack, iage i8, ihas iattention ideficit idisorder i(ADD) iand iis iprescribed
imethylphenidatei(Ritalin). iHe iand ihis iparents ishould ibe ieducated iabout ithe iside
ieffects iof imethylphenidate, iwhich iare:
- Insomnia iand idecreased iappetite
3. Monitoring ifor ia ichild ion imethylphenidate ifor iattention ideficit ihyperactivity
idisorderi(ADHD) iincludes:
- ADHD isymptoms
- Routine iheight iand iweight ichecks
- Amount iof imethylphenidate ibeing iused
4. When iprescribing iAdderall i(amphetamine iand idextroamphetamine) ito iadults iwith
iADHDithe inurse ipractitioner iwill ineed ito imonitor:
- Blood ipressure
5. Common imistakes ipractitioners imake iin itreating ianxiety idisorders iinclude:
- Thinking ia ipartial iresponse ito imedication iis iacceptable
6. An iappropriate ifirst-line idrug ito itry ifor imild ito imoderate igeneralized ianxiety
idisorderiwould ibe:
- Buspirone i(Buspar)
7. An iappropriate idrug ito iinitially itreat ipanic idisorder iis:
- Diazepam i(Valium)
8. Prior ito istarting iantidepressants, ipatients ishould ihave ilaboratory itesting ito irule iout:
- Hypothyroidism
,9. David iis ia i34-year-old ipatient iwho iis istarting ion iparoxetine i(Paxil) ifor
idepression.iDavid's ieducation iregarding ihis imedication iwould iinclude:
- He imay iexperience isexual idysfunction ibeginning ia imonth iafter ihe istarts itherapy.
10. Jamison ihas ibeen iprescribed icitalopram i(Celexa) ito itreat ihis idepression. iEducation
iregarding ihow iquickly iselective iserotonin ireuptake iinhibitor i(SSRI) iantidepressants
iworkiwould ibe:
- Appetite iand iconcentration iimprove iin ithe ifirst i1 ito i2 iweeks.
11. The iracial idifference iin idrug ipharmacokinetics iseen iin iAmerican iIndian ior
iAlaskaniNatives iare:
- Largely iunknown idue ito ilack iof istudies iof ithis ipopulation
12. Pharmacokinetics iamong iAsians iare iuniversal ito iall ithe iAsian iethnic igroups.
A. True
B. False
13. Alterations iin idrug imetabolism iamong iAsians imay ilead ito:
- Slower imetabolism iof iantidepressants, irequiring ilower idoses
14. Asians ifrom iEastern iAsia iare iknown ito ibe ifast iacetylators. iFast iacetylators:
- Require ihigher idoses iof idrugs imetabolized iby iacetylization ito iachieve iefficacy
15. Hispanic inative ihealers i(curanderas):
A. Are inot iheavily iutilized iby iHispanics iwho iimmigrate ito ithe iUnited iStates
B. Use iherbs iand iteas iin itheir itreatment iof iillness
C. Provide iunsafe iadvice ito iHispanics iand ishould inot ibe itrusted
D. Need ito ibe ilicensed iin itheir ihome icountry iin iorder ito ipractice iin ithe iUnited iStates i
16. Genetic ipolymorphisms iaccount ifor idifferences iin imetabolism, iincluding:
- Poor imetabolizers, iwho ilack ia iworking ienzyme
- Intermediate imetabolizers, iwho ihave ione iworking, iwild-type iallele iand ione
imutantiallele
- Extensive imetabolizers, iwith itwo inormally ifunctioning ialleles
17. Up ito i21% iof iAsians iare iultra-rapid i2D6 imetabolizers, ileading ito:
- Increased idosages ineeded iof idrugs imetabolized iby i2D6, isuch ias ithe
iselectiveiserotonin ireuptake iinhibitors
18. Drugs ithat iuse iCYP i3A4 iisoenzymes ifor imetabolism imay:
- Induce ithe imetabolism iof ianother idrug
, - Inhibit ithe imetabolism iof ianother idrug
19. Rifampin iis ia inonspecific iCYP450 iinducer ithat imay:
- Induce ithe imetabolism iof idrugs, isuch ias ioral icontraceptives, ileading ito
itherapeuticifailure
20. Inhibition iof iP-glycoprotein iby ia idrug isuch ias iquinidine imay ilead ito:
- Increased ilevels iof ia ico-administered idrug, isuch ias idigoxin, ithat irequires
iP-iglycoprotein ifor iabsorption iand ielimination
21. Warfarin iresistance imay ibe iseen iin ipatients iwith iVCORC1 imutation, ileading ito:
- Decreased iresponse ito iwarfarin
22. Genetic itesting ifor iVCORC1 imutation ito iassess ipotential iwarfarin iresistance iis
irequirediprior ito iprescribing iwarfarin.
A. True
B. False
23. Pharmacogenetic itesting iis irequired iby ithe iU.S. iFood iand iDrug iAdministration
iprior itoiprescribing:
- Cetuximab
24. Carbamazepine ihas ia iBlack iBox iWarning irecommending itesting ifor ithe iHLA-
B*1502iallele iin ipatients iwith iAsian iancestry iprior ito istarting itherapy idue ito:
- Increased irisk ifor iStevens-Johnson isyndrome iin iAsian ipatients iwith iHLA-
B*1502iallele
25. A igenetic ivariation iin ihow ithe imetabolite iof ithe icancer idrug iirinotecan iSN-
38 iisiinactivated iby ithe ibody imay ilead ito
- Increased iadverse idrug ireactions, isuch ias ineutropenia
26. Patients iwho ihave ia ipoor imetabolism iphenotype iwill ihave:
- Slowed imetabolism iof ia iprodrug iinto ian iactive idrug, ileading ito iaccumulation
iofiprodrug
27. A ipatient's inutritional iintake iand ilaboratory iresults ireflect ihypoalbuminemia. iThis
iisicritical ito iprescribing ibecause:
- Distribution iof idrugs ito itarget itissue imay ibe iaffected.
28. Drugs ithat ihave ia isignificant ifirst-pass ieffect:
- Are irapidly imetabolized iby ithe iliver iand imay ihave ilittle iif iany idesired iaction
29. The iroute iof iexcretion iof ia ivolatile idrug iwill ilikely ibe ithe:
- Lungs
