EUNICE
NRNP 6566 WK1-5 Midterm WITH 100% SURE ANSWERSE
Terms in this set (36)
Describe cytochrome p450 system Cytochrome p450 system is a series of enzymes used to metabolize medications
Inhibitors block metabolic activity from one or more CYP450 enzymes
Inducers increase CYP450 enzyme activity by increasing enzyme synthesis
Albumin is the plasma protein with the greatest capacity for binding drugs. Binding
Describe effect on low and high albumin
plasma proteins affect drug distribution into tissues, because only drug that is not
levels on active drug levels especially for
bound is available to penetrate tissues, bind to receptors, and exert activity. As free
drugs that are highly protein bound
drug leaves the blood stream, more bound drug is released from binding sites.
Low albumin levels malnutrition, chronic illness
toxicity in patients with low albumin levels, example malnutrition or chronic illness.
Highly protein bound drugs can lead to
This is because there are fewer than the normal sites for the drug to bind
Alternative routes include:
suppository
intravenous
intramuscular
Describe the ways the hepatic first pass
inhalational aerosol
effect- which is metabolism during first
transdermal
pass through the liver
sublingual
These allow drugs to bypass the first-pass effect and be absorbed directly into
systemic circulation
Be able to calculate creatinine clearance Male = 140-age times weight in kilograms divided by serum creatinine times 72.
using Cockgraft Gault equation: Women = CRCL (male) times 0.85
Describe what determines the frequency of half life
drug administration plasma concentration
Potentially Inappropriate Medication Use in Older Adults
Be familiar with the beers criteria and how
to call attention to medications that are most commonly problematic and thus should
to use it
be avoided in older adults
low blood state (shock or arrest), contact time with GI tract too fast (diarrhea = cant
Describe factors that affect absorption absorb), delayed stomach emptying (large meal = delayed absorption)Drug- to drug
or drug to food interactions
Describe the factors that affect distribution low albumin levels, body composition, cardiac decompensation (heart failure), age
Describe the factors that affect metabolism genetics, age, organ function
1/4
NRNP 6566 WK1-5 Midterm WITH 100% SURE ANSWERSE
Terms in this set (36)
Describe cytochrome p450 system Cytochrome p450 system is a series of enzymes used to metabolize medications
Inhibitors block metabolic activity from one or more CYP450 enzymes
Inducers increase CYP450 enzyme activity by increasing enzyme synthesis
Albumin is the plasma protein with the greatest capacity for binding drugs. Binding
Describe effect on low and high albumin
plasma proteins affect drug distribution into tissues, because only drug that is not
levels on active drug levels especially for
bound is available to penetrate tissues, bind to receptors, and exert activity. As free
drugs that are highly protein bound
drug leaves the blood stream, more bound drug is released from binding sites.
Low albumin levels malnutrition, chronic illness
toxicity in patients with low albumin levels, example malnutrition or chronic illness.
Highly protein bound drugs can lead to
This is because there are fewer than the normal sites for the drug to bind
Alternative routes include:
suppository
intravenous
intramuscular
Describe the ways the hepatic first pass
inhalational aerosol
effect- which is metabolism during first
transdermal
pass through the liver
sublingual
These allow drugs to bypass the first-pass effect and be absorbed directly into
systemic circulation
Be able to calculate creatinine clearance Male = 140-age times weight in kilograms divided by serum creatinine times 72.
using Cockgraft Gault equation: Women = CRCL (male) times 0.85
Describe what determines the frequency of half life
drug administration plasma concentration
Potentially Inappropriate Medication Use in Older Adults
Be familiar with the beers criteria and how
to call attention to medications that are most commonly problematic and thus should
to use it
be avoided in older adults
low blood state (shock or arrest), contact time with GI tract too fast (diarrhea = cant
Describe factors that affect absorption absorb), delayed stomach emptying (large meal = delayed absorption)Drug- to drug
or drug to food interactions
Describe the factors that affect distribution low albumin levels, body composition, cardiac decompensation (heart failure), age
Describe the factors that affect metabolism genetics, age, organ function
1/4
