PCB 3233 Ch. 3 Study Guide for Exam 2
When the following receptors are engaged what mechanism is initiated in a phagocyte?
- mannose receptor
(activate and enhance) - correct answer ✔✔• Activate the Lectin complement cascade
• Enhance complement fixation to pathogen surfaces
When the following receptors are engaged what mechanism is initiated in a phagocyte?
- CR3 and CR4 - correct answer ✔✔iC3b
What other ligands can CR3 and CR4 recognize?
4 things - correct answer ✔✔- LPS, lipopolysaccharide (Gram negative bacteria)
- Lipophosphoglycan
- Filamentous hemagglutinin
- Cell-surface structures on yeast
When the following receptors are engaged what mechanism is initiated in a phagocyte?
- Scavenger receptor
N,P (gp), l (Gn) - correct answer ✔✔preference for molecules that are negatively charged.
- Nucleic acids, phosphate-containing lipoteichoic acids (Gram positive bacteria) and LPS (Gram negative
bacteria)
When the following receptors are engaged what mechanism is initiated in a macrophage?
TLR's
(expressed on, detects) - correct answer ✔✔• TLR-4 expressed on Macrophages
• TLR-4 detects LPS and sends a signal to the nucleus of the macrophage to make and secrete
inflammatory cytokines as well as cytokines that activate innate immune responses
, What does TLR 4 bind to? - correct answer ✔✔lipopolysaccharide
microorganisms recognized = gram negative bacteria
What does TLR 7 bind to? - correct answer ✔✔single-stranded viral RNA's
Microorganisms
What does TLR 3 bind to? - correct answer ✔✔double-stranded viral RNA
Microorganisms
What does TLR 5 bind to? - correct answer ✔✔Flagellin, protein
Microorganisms
SIGNAL OF TLR4 signaling mechanism. step 1
name the complex that forms on the surface - correct answer ✔✔TLR4, MD2, CD14 and LPS
SIGNAL OF TLR4 signaling mechanism.
step 2 a
what binds to TIR domain underneath - correct answer ✔✔MyD88 binds to TLR4
SIGNAL OF TLR4 signaling mechanism.
step 2 b
what is activate after myd88 binds - correct answer ✔✔IRAK
4
SIGNAL OF TLR4 signaling mechanism.
When the following receptors are engaged what mechanism is initiated in a phagocyte?
- mannose receptor
(activate and enhance) - correct answer ✔✔• Activate the Lectin complement cascade
• Enhance complement fixation to pathogen surfaces
When the following receptors are engaged what mechanism is initiated in a phagocyte?
- CR3 and CR4 - correct answer ✔✔iC3b
What other ligands can CR3 and CR4 recognize?
4 things - correct answer ✔✔- LPS, lipopolysaccharide (Gram negative bacteria)
- Lipophosphoglycan
- Filamentous hemagglutinin
- Cell-surface structures on yeast
When the following receptors are engaged what mechanism is initiated in a phagocyte?
- Scavenger receptor
N,P (gp), l (Gn) - correct answer ✔✔preference for molecules that are negatively charged.
- Nucleic acids, phosphate-containing lipoteichoic acids (Gram positive bacteria) and LPS (Gram negative
bacteria)
When the following receptors are engaged what mechanism is initiated in a macrophage?
TLR's
(expressed on, detects) - correct answer ✔✔• TLR-4 expressed on Macrophages
• TLR-4 detects LPS and sends a signal to the nucleus of the macrophage to make and secrete
inflammatory cytokines as well as cytokines that activate innate immune responses
, What does TLR 4 bind to? - correct answer ✔✔lipopolysaccharide
microorganisms recognized = gram negative bacteria
What does TLR 7 bind to? - correct answer ✔✔single-stranded viral RNA's
Microorganisms
What does TLR 3 bind to? - correct answer ✔✔double-stranded viral RNA
Microorganisms
What does TLR 5 bind to? - correct answer ✔✔Flagellin, protein
Microorganisms
SIGNAL OF TLR4 signaling mechanism. step 1
name the complex that forms on the surface - correct answer ✔✔TLR4, MD2, CD14 and LPS
SIGNAL OF TLR4 signaling mechanism.
step 2 a
what binds to TIR domain underneath - correct answer ✔✔MyD88 binds to TLR4
SIGNAL OF TLR4 signaling mechanism.
step 2 b
what is activate after myd88 binds - correct answer ✔✔IRAK
4
SIGNAL OF TLR4 signaling mechanism.
