PCB 3233 Exam 2 Study Guide Chapter 3 questions well answered

PCB 3233 Exam 2 Study Guide Chapter 3

When the following receptors are engaged what mechanism is initiated in a phagocyte? Mannose, CR3
and CR4, or scavenger protein. - correct answer ✔✔CR3 abd CR4 on pathogens recognize phagocyte
receptors.

Phagocytosis is initiated when mannose receptor for LPS is present.

Initiated when Scavenger protein LPS



When the following receptors are engaged what mechanism is initiated in a macrophage? TLRs. - correct
answer ✔✔When TLR4 senses ligand LPS. Sends signal to uncles to make cytokines.



What do TLR 3, 4, 5, and 7 bind to? - correct answer ✔✔TLR 3 = Double stranded viral RNA, RNA virus;
NK kills.

TLR 4 = Lipopolysaccharrde, (-); Mmen kills.

TLR 5 = Flagellin, bacteria; intestinal epithelium kills.



Know the TLR4 signaling mechanism. - correct answer ✔✔1. MyD88 binds IRAK4

2. Traf6 bink IKK

3. IKK phosphorylated IkB and degrades.

4. Degradation of IkB leads to NFkB which allows gene transcription for cytokines.



In the previous question what 5 genes are transcribed because of TLR 4 recognition? - correct answer
✔✔1. IL-1 or IL-1B

2. IL-12

3. IL-6

4. TNF - a

5. CXCL8



What is the general term given to these 5 gene products? 2 part name - correct answer ✔✔Pro-
inflammatory Cytokines