PCB 3233 Study Guide for CH. 5 and 6
for Test 3
BCR (B cell receptor) and TCR (T cell receptor), how are they created - correct answer ✔✔T cell are
produce as result of gene rearrangement m and are highly variable and diverse in their antigen
specificity.
BCR (B cell receptor) and TCR (T cell receptor ?
where in the body are they created - correct answer ✔✔B cell are from the bone marrow
T cells are from the thymus
Structure of immunoglobulin - correct answer ✔✔2 Fab = light and heavy chain
1 Fc= both heavy chain
1 ag- binding site
Structure of T cell receptor (TCR) - correct answer ✔✔α (light) and β (heavy)
order:
Varibale regin
Constats
tansmebra
cytoplasmic tail (short)
T cell receptor (TCR) type of antigen - correct answer ✔✔bind to peptide antigens which are derived
from the pathogen's proteins. It requires presentation by MHC molecules. Cells bind one type of antigen
which must be presented to them on the surface of another human cell
Ig (BCR) type of antigen - correct answer ✔✔bind intact molecules and DO NOT require presentation.
bind to proteins/carbohydrates/lipids on the surfaces of pathogens
, Together these 8 polypeptides are called the TCR complex - correct answer ✔✔2 CD3 complexes(chr11);
one is delta and epsilon, one is gamma and epsilon; one zeta (chr.1)chain with two zeta polypeptides
Function of a T cell receptor (TCR) - correct answer ✔✔used only to recognize antigens (not effectors
themselves
Function of TCR complex - correct answer ✔✔2 transmembrane zeta chains which interact with
intracellular signaling molecules
What is the CD 3 complex - correct answer ✔✔Encoded by closely-linked genes on human chromosome
11, homologous.
Chr 11, homologous CD3γ, CD3δ, and CD3ε make it up.
needed not only for signaling but high expression.
T-cell receptor antigen-binding sites, how many per TCR and number of CDR's per receptor - correct
answer ✔✔1 antigen-binding site per TCR, and 6 CDR's per receptor (3 per chain)
T cell receptor diversity and where are most of the differences concentrated? - correct answer ✔✔Prior
to antigen stimulation: gene rearrangement = V region
Post to antigen stimulation: genes encoding TCR remain unchanged
T cell receptor diversity and where most of the differences are found are in the Hypervariable region
Severe combined immunodeficiency syndrome (SCID - correct answer ✔✔defect of 1 of the RAG genes;
combined T and B cell absence; no adaptive immune system; die in infancy unless they have bone
marrow transplant
Candida albicans infection
Omenn Syndrome - correct answer ✔✔missense mutation produces RAG protein with partial enzymatic
activity; red rash on face and shoulders; little adaptive immunity
for Test 3
BCR (B cell receptor) and TCR (T cell receptor), how are they created - correct answer ✔✔T cell are
produce as result of gene rearrangement m and are highly variable and diverse in their antigen
specificity.
BCR (B cell receptor) and TCR (T cell receptor ?
where in the body are they created - correct answer ✔✔B cell are from the bone marrow
T cells are from the thymus
Structure of immunoglobulin - correct answer ✔✔2 Fab = light and heavy chain
1 Fc= both heavy chain
1 ag- binding site
Structure of T cell receptor (TCR) - correct answer ✔✔α (light) and β (heavy)
order:
Varibale regin
Constats
tansmebra
cytoplasmic tail (short)
T cell receptor (TCR) type of antigen - correct answer ✔✔bind to peptide antigens which are derived
from the pathogen's proteins. It requires presentation by MHC molecules. Cells bind one type of antigen
which must be presented to them on the surface of another human cell
Ig (BCR) type of antigen - correct answer ✔✔bind intact molecules and DO NOT require presentation.
bind to proteins/carbohydrates/lipids on the surfaces of pathogens
, Together these 8 polypeptides are called the TCR complex - correct answer ✔✔2 CD3 complexes(chr11);
one is delta and epsilon, one is gamma and epsilon; one zeta (chr.1)chain with two zeta polypeptides
Function of a T cell receptor (TCR) - correct answer ✔✔used only to recognize antigens (not effectors
themselves
Function of TCR complex - correct answer ✔✔2 transmembrane zeta chains which interact with
intracellular signaling molecules
What is the CD 3 complex - correct answer ✔✔Encoded by closely-linked genes on human chromosome
11, homologous.
Chr 11, homologous CD3γ, CD3δ, and CD3ε make it up.
needed not only for signaling but high expression.
T-cell receptor antigen-binding sites, how many per TCR and number of CDR's per receptor - correct
answer ✔✔1 antigen-binding site per TCR, and 6 CDR's per receptor (3 per chain)
T cell receptor diversity and where are most of the differences concentrated? - correct answer ✔✔Prior
to antigen stimulation: gene rearrangement = V region
Post to antigen stimulation: genes encoding TCR remain unchanged
T cell receptor diversity and where most of the differences are found are in the Hypervariable region
Severe combined immunodeficiency syndrome (SCID - correct answer ✔✔defect of 1 of the RAG genes;
combined T and B cell absence; no adaptive immune system; die in infancy unless they have bone
marrow transplant
Candida albicans infection
Omenn Syndrome - correct answer ✔✔missense mutation produces RAG protein with partial enzymatic
activity; red rash on face and shoulders; little adaptive immunity
