PCB 3233 - Immunology Exam 3
Helper T cells associate with which class of MHC molecules? - correct answer ✔✔MHC Class 2
(extracellular infection)
Interferon function - correct answer ✔✔Viral fighting, they activate NK cells which then tell our infected
cells to die by apoptosis.
What process creates the variable region domain for both TCRs and BCRs? - correct answer ✔✔Somatic
Recombination
What the different types IFN-1? - correct answer ✔✔Alpha and Beta
What are the differences and similarities between CD8 T Cells and NK cells? - correct answer ✔✔The
both have the same cytotoxic granules, NK cells are activated faster, because they come out of the bone
marrow "ready to go". CD8 T cells recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK
cells recognize normal MHC Class 1 molecules on the surface of our cells and activating ligands that
infected cells put up on their surface.
2 types of activating ligands - correct answer ✔✔MIC - A and MIC - B, they bind to activating receptors
on activating NK cells
Type 2 interferon - correct answer ✔✔Also know as IFN- gamma, activates macrophages
IL - 12 - correct answer ✔✔Inflammatory cytokine that activates NK cells which then produces IFN -
gamma which then activate macrophages.
Which complement receptors can recognize C3b? - correct answer ✔✔CR 1 - CR 4
Which Professional Antigen Presenting Cell (Professional - APC) is strong enough to activate a CD8 T cell
from a naive state? - correct answer ✔✔Dendritic cells
, C3 convertase of the Alternative Pathway - correct answer ✔✔C3bBb
When will NK cells make interferon gamma? - correct answer ✔✔When they are activated by IL-12
(inflammatory cytokine)
Explain the activation of macrophage feedback loop - correct answer ✔✔NK cells become activated by
IL- 12, they produce interferon gamma, IFN- gamma activates macrophages, macrophages secrete IL-12
(+ other cytokines)
Describe the chains in a TCR? - correct answer ✔✔V region followed by a C region followed by a
membrane anchoring domain
Where is the most variable region of the TCR? - correct answer ✔✔V-alpha and V- beta
CDR - correct answer ✔✔area of hypervariability condensed in loops in domain farthest from the T cell
membrane
How many CDRs does each TCR chain have? - correct answer ✔✔3, CDR 1 - 3
How many binding sites do TCRs have? - correct answer ✔✔1 binding site for antigen
What is the fundamental difference between T cells and B cells? - correct answer ✔✔T cells do not
undergo any further changes after antigen stimulation whereas B cells continue to diversift
Function of B cells - correct answer ✔✔mediating effector functions
Function of T cells - correct answer ✔✔to recognize antigen
What part in T cells handles the mediating effector functions? - correct answer ✔✔the proteins
produced by the T cells
Helper T cells associate with which class of MHC molecules? - correct answer ✔✔MHC Class 2
(extracellular infection)
Interferon function - correct answer ✔✔Viral fighting, they activate NK cells which then tell our infected
cells to die by apoptosis.
What process creates the variable region domain for both TCRs and BCRs? - correct answer ✔✔Somatic
Recombination
What the different types IFN-1? - correct answer ✔✔Alpha and Beta
What are the differences and similarities between CD8 T Cells and NK cells? - correct answer ✔✔The
both have the same cytotoxic granules, NK cells are activated faster, because they come out of the bone
marrow "ready to go". CD8 T cells recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK
cells recognize normal MHC Class 1 molecules on the surface of our cells and activating ligands that
infected cells put up on their surface.
2 types of activating ligands - correct answer ✔✔MIC - A and MIC - B, they bind to activating receptors
on activating NK cells
Type 2 interferon - correct answer ✔✔Also know as IFN- gamma, activates macrophages
IL - 12 - correct answer ✔✔Inflammatory cytokine that activates NK cells which then produces IFN -
gamma which then activate macrophages.
Which complement receptors can recognize C3b? - correct answer ✔✔CR 1 - CR 4
Which Professional Antigen Presenting Cell (Professional - APC) is strong enough to activate a CD8 T cell
from a naive state? - correct answer ✔✔Dendritic cells
, C3 convertase of the Alternative Pathway - correct answer ✔✔C3bBb
When will NK cells make interferon gamma? - correct answer ✔✔When they are activated by IL-12
(inflammatory cytokine)
Explain the activation of macrophage feedback loop - correct answer ✔✔NK cells become activated by
IL- 12, they produce interferon gamma, IFN- gamma activates macrophages, macrophages secrete IL-12
(+ other cytokines)
Describe the chains in a TCR? - correct answer ✔✔V region followed by a C region followed by a
membrane anchoring domain
Where is the most variable region of the TCR? - correct answer ✔✔V-alpha and V- beta
CDR - correct answer ✔✔area of hypervariability condensed in loops in domain farthest from the T cell
membrane
How many CDRs does each TCR chain have? - correct answer ✔✔3, CDR 1 - 3
How many binding sites do TCRs have? - correct answer ✔✔1 binding site for antigen
What is the fundamental difference between T cells and B cells? - correct answer ✔✔T cells do not
undergo any further changes after antigen stimulation whereas B cells continue to diversift
Function of B cells - correct answer ✔✔mediating effector functions
Function of T cells - correct answer ✔✔to recognize antigen
What part in T cells handles the mediating effector functions? - correct answer ✔✔the proteins
produced by the T cells
