PCB3233L: Lab 9
IgG antibodies do not cause visible agglutination of ______________. - correct answer ✔✔Red Blood
Cells
The detection of IgG antibodies on red cells must be accomplished with a ______________ to IgG. -
correct answer ✔✔Reagent Antibody
Reagent antibody to IgG will bind to the __________ region of IgG, regarless of its specificity. - correct
answer ✔✔Fc
The test that detects IgG on red cells is called the _____________ or _______________. - correct answer
✔✔1. Antiglobulin Test
2. Coombs Test
There are 2 tests that require the antiglobulin test: _________ and ___________ tests. - correct answer
✔✔1. Direct
2. Indirect
The ____________ test detects IgG antibodies that have been attached within the body (in vivo). -
correct answer ✔✔Direct
Patients may attach IgG to their red blood cells in the following conditions: _______________,
_________________, and _______________. - correct answer ✔✔1. Autoimmune Hemolytic Anemia
2. Hemolytic Disease of the Newborn
3. Transfusion of Incompatible Blood
_____________: antibodies are destroying red cells causing anemia. - correct answer ✔✔Autoimmune
Hemolytic Anemia
, _____________: a mother's antibodies are passed through the placenta and attach onto the babies red
cells causing anemia. - correct answer ✔✔Hemolytic Disease of the Newborn
____________: antibodies are directed against the incompatible red blood cells following a transfusion. -
correct answer ✔✔Transfusion of Incompatible Blood
The indirect antiglobulin test (IAT) detects ____________ sensitization of red blood cells. - correct
answer ✔✔In Vitro
In the IAT test, serum or reagent antisera is first _____________ with a library of red cells. This ensures
that any potential antibody in the patient's serum has the ability to attach to the red cells. - correct
answer ✔✔Incubated
After red cells are incubated with serum or reagent antisera, the red cells are then washed to remove
unbound __________________. - correct answer ✔✔Anitbodies (Immunoglobulins)
Agglutination that occurs when the antiglobulin reagent is added indicates there was a specific
______________ between antibody in the serum and antigen present on the red cells. - correct answer
✔✔Reaction
What test is used for the detection of patient antibodies in serum to donor red cells (compatibility
testing)? - correct answer ✔✔IAT
What test is used for the detection of potentially harmful antibodies in the mom during pregnancy that
may cause harm to the developing fetus? - correct answer ✔✔IAT
What test is used for the detection of antibodies to screening cells or panel cells (antibody screen and
antibody identification)? - correct answer ✔✔IAT
What test is used for the detection of red cell phenotype using known antisera? - correct answer ✔✔IAT
The direct antiglobulin test (DAT) determines ___________ sensitization of red blood cells. - correct
answer ✔✔In Vivo
IgG antibodies do not cause visible agglutination of ______________. - correct answer ✔✔Red Blood
Cells
The detection of IgG antibodies on red cells must be accomplished with a ______________ to IgG. -
correct answer ✔✔Reagent Antibody
Reagent antibody to IgG will bind to the __________ region of IgG, regarless of its specificity. - correct
answer ✔✔Fc
The test that detects IgG on red cells is called the _____________ or _______________. - correct answer
✔✔1. Antiglobulin Test
2. Coombs Test
There are 2 tests that require the antiglobulin test: _________ and ___________ tests. - correct answer
✔✔1. Direct
2. Indirect
The ____________ test detects IgG antibodies that have been attached within the body (in vivo). -
correct answer ✔✔Direct
Patients may attach IgG to their red blood cells in the following conditions: _______________,
_________________, and _______________. - correct answer ✔✔1. Autoimmune Hemolytic Anemia
2. Hemolytic Disease of the Newborn
3. Transfusion of Incompatible Blood
_____________: antibodies are destroying red cells causing anemia. - correct answer ✔✔Autoimmune
Hemolytic Anemia
, _____________: a mother's antibodies are passed through the placenta and attach onto the babies red
cells causing anemia. - correct answer ✔✔Hemolytic Disease of the Newborn
____________: antibodies are directed against the incompatible red blood cells following a transfusion. -
correct answer ✔✔Transfusion of Incompatible Blood
The indirect antiglobulin test (IAT) detects ____________ sensitization of red blood cells. - correct
answer ✔✔In Vitro
In the IAT test, serum or reagent antisera is first _____________ with a library of red cells. This ensures
that any potential antibody in the patient's serum has the ability to attach to the red cells. - correct
answer ✔✔Incubated
After red cells are incubated with serum or reagent antisera, the red cells are then washed to remove
unbound __________________. - correct answer ✔✔Anitbodies (Immunoglobulins)
Agglutination that occurs when the antiglobulin reagent is added indicates there was a specific
______________ between antibody in the serum and antigen present on the red cells. - correct answer
✔✔Reaction
What test is used for the detection of patient antibodies in serum to donor red cells (compatibility
testing)? - correct answer ✔✔IAT
What test is used for the detection of potentially harmful antibodies in the mom during pregnancy that
may cause harm to the developing fetus? - correct answer ✔✔IAT
What test is used for the detection of antibodies to screening cells or panel cells (antibody screen and
antibody identification)? - correct answer ✔✔IAT
What test is used for the detection of red cell phenotype using known antisera? - correct answer ✔✔IAT
The direct antiglobulin test (DAT) determines ___________ sensitization of red blood cells. - correct
answer ✔✔In Vivo
