PCB 3233 EXAM 2 questions with complete solutions

PCB 3233 EXAM 2

Induced innate immune response - correct answer ✔✔-Inflammation

-Leukocytes called into the site of infection

-Soluble molecules made and secreted into the blood and brought to the site of the infection



Leukocytes in the order to action - correct answer ✔✔1. Neutrophils - Mass quantities

2. Monocytes

3.Lymphocytes - days later



2 cell type recognition - correct answer ✔✔1. NK - looking at your own cells

2. Macrophages - looking at pathogen directly



Macrophages - correct answer ✔✔use toll like receptors and phagocytic receptors



PAMP - correct answer ✔✔pathogen associated molecular patterns - on pathogen



PRR - correct answer ✔✔pattern recognition receptors - on leukocyte



Are there different receptor used for phagocytosis vs. cytokine creation and secretion(signalling)? -
correct answer ✔✔yes



What are the 5 cytokines? - correct answer ✔✔IL-1

TNF-a

IL-6

CXCL8

IL-12

,Which cytokines are pyrogens? - correct answer ✔✔IL-1

TNF-a

IL-6



What do heat cytokines (Pyrogens) lead to? - correct answer ✔✔Lead to fever



Which cytokines activate endothelial cells? - correct answer ✔✔IL-1 and TNF-a



What does the activation of endothelial cells lead to? - correct answer ✔✔Vasodilation and Vascular
premeability



NK cells provides an early response for which kind of infection? - correct answer ✔✔Viral Infection



NK recognizes two types of receptors - correct answer ✔✔Activating receptors and inhibitory receptors



Activating receptors recognize - correct answer ✔✔(Stress induced) activating ligands which leads to
apoptosis.



Inhibitory receptors recognizes - correct answer ✔✔MHC 1 on all nucleated cells.



1st effector cell - correct answer ✔✔Resident Macrophages which is prevalent in connective tissues



CR1 (complement receptor 1) binds to? - correct answer ✔✔C3b



C3b is degraded by what to become iC3b? - correct answer ✔✔Factor I



NK cells can detect? - correct answer ✔✔MHC molecules



Which receptor can recognize both Gram(-) and Gram(+)? - correct answer ✔✔Scavenger Receptor A
(SR-A)

, Which leukocyte would be first out to the sight of infection in mass quantities? - correct answer
✔✔Neutrophils



Macrophages Receptors (PRR): - correct answer ✔✔Mannose Receptor

CR-3

CR-4

Dectin-1

SR-A (Scavenger Receptor-A)

SR-B (Scavenger Receptor - B)

LPS (also known as CD14)

TLR

MARCO



Can all nucleated cells use MHC 1? - correct answer ✔✔yes



Macrophages are longlived compared to what? - correct answer ✔✔Neutrophils



What can CR1 do for you? - correct answer ✔✔Bind to C3b and phagocytose what ever C3b is bound to



What are the 4 TLRs(Toll-Like Receptors)? - correct answer ✔✔TLR-3

TLR-7

TLR-5

TLR-4



What are the internal TLRs? - correct answer ✔✔TLR-3:Double stranded Viral RNA

TLR-7: Single stranded Viral RNA



What does CR-3 and CR-4 recognize? - correct answer ✔✔iC3b and LPS