PCB 3233 IMMUNOLOGY - EXAM 3
Which cell types can become a plasma cell? - correct answer ✔✔All the above (a memory B-cell, an
activated B-cell, a centrocyte
The types of human MHC II presenting molecules are: - correct answer ✔✔HLA-DP, HLA-DQ, HLA-DR
which present peptide to CD4 T-cells
__________ has an alpha chain and a beta chain in their structure while ________ only has an alpha
chain in its structure? - correct answer ✔✔MHC II, MHC I
What process(es) are used after activation to make MHC I and II binding sites better? - correct answer
✔✔None of the above (Somatic recombination, somatic hypermutation, isotype switching
Burkitt's lymphoma is due to a translocation of the ________ gene next of one of the ________ genes. -
correct answer ✔✔MYC, Ig
You would expect the IgA and IgB genes to be turned on (expressed) during which stage/s? - correct
answer ✔✔All the above (the small pre B cell, mature B cell, immature B cell
T-cell receptor diversity is established - correct answer ✔✔Before antigen stimulation
The types of human MHC I presenting molecules are: - correct answer ✔✔HLA-A, HLA-B and HLA-C
which present peptide to CD8 T-cells
Receptor editing - correct answer ✔✔A & B (is done on the light chain, can be utilized in an attempt to
rescue a B-cell that has a self-reactive receptor
Which one of the following is in the correct sequence? - correct answer ✔✔Early Pro-B, Late Pro-B, Large
Pre-B, Small Pre-B, Immature B-cell
, When/where are N and P nucleotide additions added to the variable regions (binding site? - correct
answer ✔✔During somatic recombination
Which chemokine/s call/s a B-cell into the follicle of a secondary lymphoid tissue? - correct answer
✔✔CXCL 13
Which cell/s is/are lymphocyte/s? - correct answer ✔✔None of the above (neutrophils, macrophages,
dendritic cells
Which of the following is/are considered proto-oncogenes? - correct answer ✔✔A & B (BCL2, MYC)
A mature B-cell has: - correct answer ✔✔IgM, IgD and IgA and IgB on the surface
True of false: CCL19 and CCL21 direct a B-cell out of the blood stream, across HEV's and into a secondary
lymphocyte toward the T-cell era. - correct answer ✔✔True
The peptide-binding groove of an MHC class I molecule is composed of the following extracelllular
dendritic cells? - correct answer ✔✔a1 : a2
A beta (B) chain of a TCR has: - correct answer ✔✔1 variable region and 1 constant region
The genetic diversity of the MHC molecules binding site is due to: - correct answer ✔✔Genetic
polymorphism
Follicular dendritic cells: - correct answer ✔✔A & B (are present in germinal centers, are present in
secondary lymphoid
Which disease state is caused by loss of approximately 80% of the RAG proteins enzymatic activity and
misssense mutation? (hint: infant has a red rash on the face and shoulders) - correct answer ✔✔Omenn
Syndrome
Which cell types can become a plasma cell? - correct answer ✔✔All the above (a memory B-cell, an
activated B-cell, a centrocyte
The types of human MHC II presenting molecules are: - correct answer ✔✔HLA-DP, HLA-DQ, HLA-DR
which present peptide to CD4 T-cells
__________ has an alpha chain and a beta chain in their structure while ________ only has an alpha
chain in its structure? - correct answer ✔✔MHC II, MHC I
What process(es) are used after activation to make MHC I and II binding sites better? - correct answer
✔✔None of the above (Somatic recombination, somatic hypermutation, isotype switching
Burkitt's lymphoma is due to a translocation of the ________ gene next of one of the ________ genes. -
correct answer ✔✔MYC, Ig
You would expect the IgA and IgB genes to be turned on (expressed) during which stage/s? - correct
answer ✔✔All the above (the small pre B cell, mature B cell, immature B cell
T-cell receptor diversity is established - correct answer ✔✔Before antigen stimulation
The types of human MHC I presenting molecules are: - correct answer ✔✔HLA-A, HLA-B and HLA-C
which present peptide to CD8 T-cells
Receptor editing - correct answer ✔✔A & B (is done on the light chain, can be utilized in an attempt to
rescue a B-cell that has a self-reactive receptor
Which one of the following is in the correct sequence? - correct answer ✔✔Early Pro-B, Late Pro-B, Large
Pre-B, Small Pre-B, Immature B-cell
, When/where are N and P nucleotide additions added to the variable regions (binding site? - correct
answer ✔✔During somatic recombination
Which chemokine/s call/s a B-cell into the follicle of a secondary lymphoid tissue? - correct answer
✔✔CXCL 13
Which cell/s is/are lymphocyte/s? - correct answer ✔✔None of the above (neutrophils, macrophages,
dendritic cells
Which of the following is/are considered proto-oncogenes? - correct answer ✔✔A & B (BCL2, MYC)
A mature B-cell has: - correct answer ✔✔IgM, IgD and IgA and IgB on the surface
True of false: CCL19 and CCL21 direct a B-cell out of the blood stream, across HEV's and into a secondary
lymphocyte toward the T-cell era. - correct answer ✔✔True
The peptide-binding groove of an MHC class I molecule is composed of the following extracelllular
dendritic cells? - correct answer ✔✔a1 : a2
A beta (B) chain of a TCR has: - correct answer ✔✔1 variable region and 1 constant region
The genetic diversity of the MHC molecules binding site is due to: - correct answer ✔✔Genetic
polymorphism
Follicular dendritic cells: - correct answer ✔✔A & B (are present in germinal centers, are present in
secondary lymphoid
Which disease state is caused by loss of approximately 80% of the RAG proteins enzymatic activity and
misssense mutation? (hint: infant has a red rash on the face and shoulders) - correct answer ✔✔Omenn
Syndrome
